7 research outputs found
Ligand Effect in Platinum-Catalyzed Cycloisomerization of 1,6-Enynes: Water or Carbon Monoxide, a Similar Role despite Distinct Electronic Properties?
The PtCl<sub>2</sub>-catalyzed cycloisomerization of
1,6-enynes
is considerably accelerated in the presence of carbon monoxide. The
effect of CO has been explained by the reinforcement of the electrophilicity
of the alkyne moiety once ligated to the Ï-acidic [PtCl<sub>2</sub>(CO)] fragment. However, platinum is also described as weakly
capable of back-donation toward CO. A theoretical study has been carried
out to shed light on this apparent contradiction. An alternative explanation
based on the approach of CO onto the [PtCl<sub>2</sub>(η<sup>4</sup>-(1,6-enyne))] complex is proposed. When CO is ligated to
PtCl<sub>2</sub>, the triple-bond coordination is favored, yet there
is no positive influence on the formation of the cyclopropylcarbene
key intermediate. The role of CO is actually comparable to that of
a water molecule
Application of Cooperative Iron/Copper Catalysis to a Palladium-Free Borylation of Aryl Bromides with Pinacolborane
A new cooperative copper/iron catalysis
for the borylation of various
aryl bromides with pinacolborane, at â10 °C, is reported.
Use of the toxic, precious metal Pd is avoided. The mechanism of the
protodebromination side reaction is discussed
Enantioselective Reduction of Noncovalent Complexes of Amino Acids with Cu<sup>II</sup> via Resonant Collision-Induced Dissociation: Collision Energy, Activation Duration Effects, and RRKM Modeling
Formation of noncovalent complexes is one of the approaches
to
perform chiral analysis with mass spectrometry. Enantiomeric distinction
of amino acids (AAs) based on the relative rate constants of competitive
fragmentations of quaternary copper complexes is an efficient method
for chiral differentiation. Here, we studied the complex [CuII,(Phe,PhG,Pro-H)]+ (m/z 493) under resonant collision-induced dissociation conditions while
varying the activation time. The precursor ion can yield two main
fragments through the loss of the non-natural AA phenylglycine (PhG):
the expected product ion [CuII,(Phe,Pro-H)]+ (m/z 342) and the reduced product
ion [CuI,(Phe,Pro)]+ (m/z 343). Enantioselective reduction describes the difference
in relative abundance of these ions, which depends on the chirality
of the precursor ion: the formation of the reduced ion m/z 343 is favored in homochiral complexes (DDD)
compared to heterochiral complexes (such as LDD). Energy-resolved
mass spectrometry data show that reduction, which arises from rearrangement,
is favored at a low collision energy (CE) and long activation time
(ActT), whereas direct cleavage preferentially occurs at a high CE
and short ActT. These results were confirmed with kinetic modeling
based on RRKM theory. For this modeling, it was necessary to set a
pre-exponential factor as a reference, so that the E0 values obtained are relative values. Interestingly,
these simulations showed that the critical energy E0 required to form the reduced ion is comparable in both
homochiral and heterochiral complexes. However, the formation of
product ion m/z 342 through direct
cleavage is associated with a lower E0 in heterochiral complexes. Consequently, enantioselectivity would
not be caused by enhanced reduction in homochiral complexes but rather
by direct cleavage being favored in heterochiral complexes
Energy-Resolved Ion Mobility Spectrometry: Composite Breakdown Curves for Distinguishing Isomeric Product Ions
Identification of lipopeptides (LpAA)
synthesized
from bacteria involves the study of structural characterization. Twenty LpAA have been characterized using commercial tandem high-resolution
mass spectrometers in negative electrospray, employing nonresonant
excitation in âRF onlyâ collision cells and generally
behave identically. However, [LpAA-H]â (AA = Asp or Glu) shows surprising fragmentation pathways, yielding
a complementary fatty acid carboxylate and dehydrated amino acid fragment
anions. In this study, the dissociation mechanisms of [C12Glu-H]â were determinate using energy-resolved mass spectrometry
(ERMS). Product ion breakdown profiles are, generally, unimodal with
full width at half-maximum (fwhm) increasing as product ion m/z ratios decrease, except for the two
product ions of interest (fatty acid carboxylate and dehydrated glutamate)
characterized by broad and composite profiles. Such behavior was already
shown for other ions using a custom-built guided ion beam mass spectrometer.
In this study, we investigate the meaning of these particular profiles
from an ERMS breakdown, using fragmentation mechanisms depending on
the collision energy. ERMS on line with ion mobility spectrometry
(IMS), here called ER-IMS, provides a way to probe such questions.
Broad or composite profiles imply that the corresponding product ions
may be generated by two (or more) pathways, resulting in common or
isomeric product ion structures. ER-IMS analysis indicates that the
fatty acid carboxylate product ion is produced with a common structure
through different pathways, while dehydrated glutamate has two isomeric
forms depending on the mechanism involved. Drift time values correlate
with the calculated collision cross section that confirms the product
ion structures and fragmentation mechanisms
A Lithium Amide Protected Against Protonation in the Gas Phase: Unexpected Effect of LiCl
In
cold THF and in the presence of LiCl, a lithium pyrrolidinylamide
forms a 1:1 mixed aggregate, which is observed directly by ESI-MS.
Gas-phase protonation of this species leads to selective transfer
of H<sup>+</sup> to the chlorine, suggesting that LiCl shields the
amide nitrogen and prevents its direct protonation
Secondary Phosphine OxideâGold(I) Complexes and Their First Application in Catalysis
A series of new secondary phosphine
oxide (SPO)âgoldÂ(I)
complexes have been synthesized and characterized by X-ray crystallography.
Complexes exhibited dimeric structures interconnected by OâH···Cl
hydrogen bonds. Their first use in homogeneous catalysis is reported
and suggests a broad field of application in prototypical enyne cycloisomerization
and hydroxy- and methoxycyclization reactions
Assessing Ligand and Counterion Effects in the Noble Metal Catalyzed Cycloisomerization Reactions of 1,6-Allenynes: a Combined Experimental and Theoretical Approach
1,6-Allenynes
are useful mechanistic probes in noble-metal catalysis,
since they can give rise to very distinct products in a highly selective
fashion. Various cycloisomerization reactions have been described,
and discrete mechanisms have been postulated. Of particular interest,
whereas Alder-ene types of products can be obtained in a variety of
ways using noble-metal catalysts (Au, Pt, Rh, ...), hydrindienes have
been reported solely with gold and platinum under specific conditions.
It was shown in a previous study that this intriguing transformation
required the presence of chloride ligands at the active catalytic
species. Herein, the factors governing the fate of 1,6-allenynes under
cycloisomerization conditions have been studied more thoroughly, revealing
a much more complex scenario. The nature of ligands, counterions,
and metals was examined, showing that hydrindienes can be isolated
in the absence of halides, using electron-rich, bulky triorganophosphines
or carbene ligands. This crucial finding could also be used to access
hydrindienes in high yields, not only with gold or platinum but also
with silver. On the basis of mass spectrometry, NMR spectroscopy,
and computations, refined mechanistic scenarios have been put forward,
also rationalizing counterion effects. Notably, a metal vinylidene
intermediate has been proposed for the formation of the hydrindiene
derivatives. Finally, in the presence of trisÂ((triphenylphosphine)Âgold)Âoxonium
tetrafluoroborate as catalyst, a new pathway has been unveiled, involving
gold alkyne Ï,Ï complexes and leading to previously unobserved
[2 + 2] cycloaddition compounds