Transcriptional analysis of the conidiation pattern shift of the entomopathogenic fungus Metarhizium acridum in response to different nutrients

Distribution of total clean tags and distinct clean tags over different tag abundance categories. Numbers in square brackets demonstrate the range of copy numbers for a specific category of tags. For example, “[2, 5]” means the tags in this category have two to five copies. Numbers in parentheses show the total tag copy number for all the tags in that category. (TIF 5755 kb

Electro-optics of blue phase liquid crystal in field-perpendicular direction

The electro-optic effect is the working principle of blue phase (BP) liquid crystals, and it describes the relationship between the field-induced birefringence of BPs and the field strength. Due to the electrostriction of BP crystals under the electric field, an orthorhombic or tetragonal crystal is usually obtained when the field is applied along one of the twofold axes of a BP crystal, leading to the optical biaxiality under electric field. Such field-induced optical biaxiality of BPs has been predicted and observed, but its dependence on the field strength has not been investigated. In this research, we analyze the electro-optics in the field-perpendicular direction by measuring the birefringence in highly ordered BP I(110) crystals perpendicular to the electric field. Results reveal that BP I crystals in the field-perpendicular direction show an electro-optic coefficient of the order of 10−10 m/V2 that may result from the large lattice deformation of BP crystals perpendicular to the electric field. Our research provides important experimental evidence for the tensorial properties of BP Kerr effect and may have important implications on the engineering of BP electro-optical devices in practical applications.Zhang Y., Yoshida H., Wang Q.H., et al. Electro-optics of blue phase liquid crystal in field-perpendicular direction. Applied Physics Letters 122, 161107 (2023); https://doi.org/10.1063/5.0142383

GNN-SL: Sequence Labeling Based on Nearest Examples via GNN

To better handle long-tail cases in the sequence labeling (SL) task, in this work, we introduce graph neural networks sequence labeling (GNN-SL), which augments the vanilla SL model output with similar tagging examples retrieved from the whole training set. Since not all the retrieved tagging examples benefit the model prediction, we construct a heterogeneous graph, and leverage graph neural networks (GNNs) to transfer information between the retrieved tagging examples and the input word sequence. The augmented node which aggregates information from neighbors is used to do prediction. This strategy enables the model to directly acquire similar tagging examples and improves the general quality of predictions. We conduct a variety of experiments on three typical sequence labeling tasks: Named Entity Recognition (NER), Part of Speech Tagging (POS), and Chinese Word Segmentation (CWS) to show the significant performance of our GNN-SL. Notably, GNN-SL achieves SOTA results of 96.9 (+0.2) on PKU, 98.3 (+0.4) on CITYU, 98.5 (+0.2) on MSR, and 96.9 (+0.2) on AS for the CWS task, and results comparable to SOTA performances on NER datasets, and POS datasets.Comment: preprin

Association of urine autoantibodies with disease activity in systemic lupus erythematosus

ObjectiveThe presence of urinary autoantibodies in patients with systemic lupus erythematosus (SLE) has been confirmed by several studies; however, the significance of their presence in urine remains unclear. This study aims to further investigate the association between urine autoantibodies and disease activity as well as organ involvement in SLE.MethodsThis cross-sectional study included 89 SLE patients. Data collected included anti-nuclear antibody (ANA), anti-ENA antibodies, and anti-dsDNA antibody levels in both serum and urine, complement (C) 3, C4 levels in serum, SLE disease activity index-2000 (SLEDAI-2000), renal domains of SLEDAI (RSLEDAI) and non-renal SLEDAI (NRSLEDAI).ResultsThe rate of positive urine ANA (uANA) was 33.3% (29/87) among the enrolled patients. Compared to the uANA negative group, the positive group exhibited significantly higher SLEDAI-2000 scores (7.85 ± 5.88 vs. 18.69 ± 6.93, p < 0.001), RSLEDAI scores [0 (0, 4.0) vs. 12.0 (8.0, 16.0), p < 0.001], and NRSLEDAI [4 (2.0, 8.0) vs. 6.0 (4.0, 9.5), p = 0.038]. Patients with positive urine anti-Sm antibody demonstrated significantly elevated SLEDAI-2000 scores compared to those who were negative (25.0 ± 8.80 vs. 10.09 ± 6.63, p < 0.001). Similarly, they also had higher RSLEDAI [16.0 (12.0, 16.0) vs. 4.0 (0, 8.0), p < 0.001] and NRSLEDAI [9.5 (6.0, 13.5) vs. 4.0 (3.0, 8.0), p = 0.012], as well as a greater prevalence of renal involvement compared to their negative counterparts (100% vs. 58.2, p = 0.022). There was a positive correlation between uANA titer and both SLEDAI-2000 (rs = 0.663, p < 0.001) and RSLEDAI (rs = 0.662, p < 0.001). The serum anti-dsDNA antibody level did not exhibit a significant correlation with RSLEDAI (rs = 0.143, p = 0.182). Conversely, the urine anti-dsDNA antibody level demonstrated a significant positive correlation with RSLEDAI (rs = 0.529, p < 0.001).ConclusionUrine ANA is associated with both global SLEDAI and RSLEDAI scores. Urine anti-Sm antibody is associated with an increased incidence of renal involvement in SLE. The urine anti-dsDNA antibody level, rather than the serum anti-dsDNA antibody level, exhibits a significant association with RSLEDAI in SLE

Effect of Two Kinds of Bone Replacement Materials on Bone Formation in Repairing Bone Defects Around Mandibular Posterior Area: a Case Study of Bone Defects Around Mandibular Posterior Area Caused by Boxing

Objective: To investigate the effect of two kinds of bone replacement materials on bone formation in repairing bone defect around mandibular posterior area. Methods: A total of 60 patients with Bone defects around mandibular posterior area caused by boxing were selected from a hospital from January 2020 to June 2020. They were divided into Perio Glas (group P) and Bone Plant (group B) by random number table method, with 30 patients in each group. Perio Glas Bone graft was used in group P and Bone Plant graft was used in group B. The vertical height and buccal lingual bone plate width of the two groups were observed at baseline and after treatment, and the success rate of implants was compared between the two groups. Results: The success rate of implant in group P was significantly lower than that in group B (P < 0.05). The vertical height and buccal lingual bone plate width in group P were significantly lower than those in group B (P < 0.05). Conclusion: Compared with Perio Glas, Bone Plant can better maintain the vertical height and buccal lingual Bone plate width of patients with Bone defects around mandibular posterior area caused by boxing, and has better effect of inducing Bone regeneration and osteogenesis

Application of Nanotechnology in Oral Implantation Based on Exercise-Induced Tooth Injury

With the development of sports in various countries, more and more people participate in sports, and the rate of sports injuries to the oral and maxillofacial system also increases, especially the dental injuries caused by boxing are more common. At the same time, with the improvement of modern production, people's basic needs have been continuously met, and more and more people have begun to pay attention to their physical health and appearance characteristics. Among them, dental plastic correction and restoration have received great attention. In addition, with the application of nanotechnology in various fields in recent years, scholars at home and abroad have also tried or have continued to introduce nanomaterials into oral clinics, in order to improve and develop the application of oral materials, so that the oral clinic can be continuously improved and developed. Therefore, this paper reviews the current situation of sports injury of the oral and maxillofacial system, the mechanical analysis of tooth injury, the current situation of tooth restoration and the application of nanotechnology in the field of oral implantation

Kinetics of non-structural protein 1, IgM and IgG antibodies in dengue type 1 primary infection

<p>Abstract</p> <p>Background</p> <p>Early and accurate diagnosis of dengue infection is essential for control of disease outbreaks. Recently, the dengue virus non-structural antigen 1 (NS1), a conserved and secreted glycoprotein, has been used as a marker for early diagnosis of dengue with convenience and cost-effectiveness. Serological tests of dengue IgM and IgG antibodies are still the most widely used for diagnosis of dengue. In order to assess combined diagnostic value of these tests, we study the kinetic profiles of circulating NS1, dengue IgM and IgG antibodies over the course of the disease by using an in-house dengue type 1 (DENV1) specific NS1 capture ELISA and the commercial Panbio Dengue IgM and IgG capture ELISAs.</p> <p>Results</p> <p>A panel of 313 acute-and early convalescent-phase serum specimens from 140 DENV1 primary infected patients during an outbreak of dengue in Guangzhou, China, in 2006 were studied. Dengue NS1 presented high levels in acute-phase serum samples. It was detectable as early as day 1 of illness, and up to 14 day after onset. The sensitivity of NS1 detection was ranged from 81.8% to 91.1% with samples taken during the first 7 days. Anti-dengue IgM antibody was detectable on the third day of onset with the positive rate of 42.9%, and rapidly increasing to 100% by day 8 of illness. Anti-dengue IgG antibody was detectable on the fifth day of onset with low level at the first week of onset, and slowly increasing to 100% by day 15 of illness. Combining the results of NS1 and IgM antibody detection allowed positive diagnosis in 96.9% -100% for samples taken after day 3 of onset.</p> <p>Conclusions</p> <p>Dengue NS1 detection might shorten the window period by first few days of illness. A combination of dengue NS1 antigen and IgM antibody testing facilitates enhanced diagnosis rates. The procedures should be suitable for developing countries where dengue is endemic.</p