Notes from lockdown: A series of reflections on some of the political and cultural impacts of the pandemic

A series of reflections on Covid-19 that looks at: how the pandemic affects processes of bordering and increases the indeterminate grey zones within which so many people are forced to live; the way nurses are presented in the media and the hypocrisy of praising them in a moment of crisis while simultaneously devaluing their work and underpaying them; health inequalities in Newham; the inequalities in the craft sector spotlighted by the pandemic; the relationships between radical neighbourliness and local politics; how perceptions of time have been affected during lockdown - and how 24-7 capitalism may seek to take advantage of this radical reorganisation of time

Density Modulations and Addition Spectra of Interacting Electrons in Disordered Quantum Dots

We analyse the ground state of spinless fermions on a lattice in a weakly disordered potential, interacting via a nearest neighbour interaction, by applying the self-consistent Hartree-Fock approximation. We find that charge density modulations emerge progressively when r_s >1, even away from half-filling, with only short-range density correlations. Classical geometry dependent "magic numbers" can show up in the addition spectrum which are remarkably robust against quantum fluctuations and disorder averaging.Comment: 4 pages, 3 eps figure

The Addition Spectrum and Koopmans' Theorem for Disordered Quantum Dots

We investigate the addition spectrum of disordered quantum dots containing spinless interacting fermions using the self-consistent Hartree-Fock approximation. We concentrate on the regime r_s >~1, with finite dimensionless conductance g. We find that in this approximation the peak spacing fluctuations do not scale with the mean single particle level spacing for either Coulomb or nearest neighbour interactions when r_s >~1. We also show that Koopmans' approximation to the addition spectrum can lead to errors that are of order the mean level spacing or larger, both in the mean addition spectrum peak spacings, and in the peak spacing fluctuations.Comment: 35 pages including 22 figures (eps

Correlations in the cotunneling regime of a quantum dot

Off-resonance conductance through weakly coupled quantum dots ("valley conductance") is governed by cotunneling processes in which a large number of dot states participate. Virtually the same states participate in the transport at consecutive valleys, which leads to significant valley-valley conductance correlations. These correlations are calculated within the constant interaction model. Comparison with experiment shows that these correlations are less robust in reality. Among the possible reasons for this is the breakdown of the constant interaction model, accompanied by "scrambling" of the dot as the particle number is varied.Comment: 10 pages, 4 eps-figures; reference adde

Liver transplantation for hepatocellular carcinoma: Management after the transplant

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153700/1/ajt15697.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153700/2/ajt15697_am.pd

Mesoscopic fluctuations of the ground state spin of a small metal particle

We study the statistical distribution of the ground state spin for an ensemble of small metallic grains, using a random-matrix toy model. Using the Hartree Fock approximation, we find that already for interaction strengths well below the Stoner criterion there is an appreciable probability that the ground state has a finite, nonzero spin. Possible relations to experiments are discussed.Comment: 4 pages, RevTeX; 1 figure included with eps

Feasibility of Using Ultra-High Field (7 T) MRI for Clinical Surgical Targeting

The advantages of ultra-high magnetic field (7 Tesla) MRI for basic science research and neuroscience applications have proven invaluable. Structural and functional MR images of the human brain acquired at 7 T exhibit rich information content with potential utility for clinical applications. However, (1) substantial increases in susceptibility artifacts, and (2) geometrical distortions at 7 T would be detrimental for stereotactic surgeries such as deep brain stimulation (DBS), which typically use 1.5 T images for surgical planning. Here, we explore whether these issues can be addressed, making feasible the use of 7 T MRI to guide surgical planning. Twelve patients with Parkinson's disease, candidates for DBS, were scanned on a standard clinical 1.5 T MRI and a 7 T MRI scanner. Qualitative and quantitative assessments of global and regional distortion were evaluated based on anatomical landmarks and transformation matrix values. Our analyses show that distances between identical landmarks on 1.5 T vs. 7 T, in the mid-brain region, were less than one voxel, indicating a successful co-registration between the 1.5 T and 7 T images under these specific imaging parameter sets. On regional analysis, the central part of the brain showed minimal distortion, while inferior and frontal areas exhibited larger distortion due to proximity to air-filled cavities. We conclude that 7 T MR images of the central brain regions have comparable distortions to that observed on a 1.5 T MRI, and that clinical applications targeting structures such as the STN, are feasible with information-rich 7 T imaging

Colour terms affect detection of colour and colour-associated objects suppressed from visual awareness

The idea that language can affect how we see the world continues to create controversy. A potentially important study in this field has shown that when an object is suppressed from visual awareness using continuous flash suppression (a form of binocular rivalry), detection of the object is differently affected by a preceding word prime depending on whether the prime matches or does not match the object. This may suggest that language can affect early stages of vision. We replicated this paradigm and further investigated whether colour terms likewise influence the detection of colours or colour-associated object images suppressed from visual awareness by continuous flash suppression. This method presents rapidly changing visual noise to one eye while the target stimulus is presented to the other. It has been shown to delay conscious perception of a target for up to several minutes. In Experiment 1 we presented greyscale photos of objects. They were either preceded by a congruent object label, an incongruent label, or white noise. Detection sensitivity (d’) and hit rates were significantly poorer for suppressed objects preceded by an incongruent label compared to a congruent label or noise. In Experiment 2, targets were coloured discs preceded by a colour term. Detection sensitivity was significantly worse for suppressed colour patches preceded by an incongruent colour term as compared to a congruent term or white noise. In Experiment 3 targets were suppressed greyscale object images preceded by an auditory presentation of a colour term. On congruent trials the colour term matched the object’s stereotypical colour and on incongruent trials the colour term mismatched. Detection sensitivity was significantly poorer on incongruent trials than congruent trials. Overall, these findings suggest that colour terms affect awareness of coloured stimuli and colour- associated objects, and provide new evidence for language-perception interaction in the brain

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population