Conjugated Nanowire Sensors via High-Energy Single-Particle-Induced Linear Polymerization of 9,9\u27-Spirobi[9H‑fluorene] Derivatives

Nanostructures composed of conjugated polymers or π-conjugated molecules provide sensing platforms with large specific surface areas. One of the feasible approaches to accessing such nanostructured miniaturized sensors with ultrahigh sensitivity is to develop a network of organic nanowires with optical/electronic properties that can measure signals upon interacting with the analytes at their surfaces. In this work, organic nanowires with controlled number density and uniform length were fabricated by one-dimensional solid-state polymerization of 9,9\u27-spirobi[9H-fluorene] (SBF) derivatives triggered by high-energy single particles. SBF was chosen as a conjugated molecular motif with the interplay of high density of π-electrons, high solubility, and uniform solid-state structures, allowing us to fabricate sensing platforms via solution processing. The as-deposited energy density in linear polymerization nanospace was theoretically analyzed by a collision model, interpreting nanowire sizes at subnanometer levels. The substitution of bromine atoms was confirmed to be effective not only for the higher collision probability of the incident particles but also for the remarkable increase in radiolytic neutral radical yield via C−Br cleavages or electron-dissociative attachments onto the bromine atoms. The fluorescence spectra of SBF-based nanowires were different from those of SBF derivatives due to extended bond formation as a result of polymerization reactions. Fluorescence was quenched by the addition of nitrobenzene, indicating the potential use of our nanowires for fluorometric sensing applications. Microwave-based conductivity measurements revealed that the SBF-based nanowires exhibited charge carrier transport property upon photoexcitation, and that the conductivity was changed upon treatment with nitrobenzene vapors. The presented strategy of bromination of aromatic rings for efficient fabrication of controlled nanowire networks with favorable fluorescent and charge transport properties of nanowires advances the development of nanostructured sensing systems

A randomized, double-blind study to evaluate the acid-inhibitory effect of vonoprazan (20 mg and 40 mg) in patients with proton-pump inhibitor-resistant erosive esophagitis

Background: Standard treatment for patients with erosive esophagitis (EE) is proton-pump inhibitors (PPIs), but some patients are resistant to PPIs. We aimed to evaluate the acid-inhibitory effects and efficacy of a novel potassium-competitive acid blocker (vonoprazan) in patients with PPI-resistant EE. Methods This randomized, double-blind, multicenter study of vonoprazan evaluated gastric and esophageal pH over a 24-hour period as the primary endpoint and EE healing rate as the secondary endpoint. Following a 7 to 14-day run-in period (lansoprazole 30 mg treatment), patients with endoscopically confirmed PPI-resistant EE received vonoprazan 20 mg or 40 mg for 8 weeks. Results Patients were randomized to receive vonoprazan 20 mg ( n = 9) or 40 mg ( n = 10). Over a 24-hour period; both groups showed a significant increase from baseline in the percentage of time gastric pH ≥ 4, referred to as pH 4 holding time ratio (HTR): an increase from 73.21% to 96.46% in the 20 mg group, and from 69.97% to 100.00% in the 40 mg group. Increases from baseline in esophageal pH 4 HTRs were not significant. The 40 mg group showed greater increases in gastric and esophageal pH 4 HTRs compared with the 20 mg group, but differences between groups were not significant. After 8 weeks’ treatment, the healing rate in subjects with baseline EE grades A–D was 60.0% (3/5 patients) in the 20 mg group and 71.4% (5/7 patients) in the 40 mg group. Vonoprazan was generally well tolerated. One patient (40 mg group) experienced four treatment-emergent adverse events (TEAEs) (unrelated to study drug), leading to study discontinuation. Conclusions Vonoprazan 20 mg and 40 mg effectively inhibited gastric acid secretion over a 24-hour period with significantly increased gastric pH 4 HTR, and resulted in an EE healing rate > 60.0% in this study. Vonoprazan treatment may be valuable for patients with PPI-resistant E

Pharmacokinetics and Safety of Triple Therapy with Vonoprazan, Amoxicillin, and Clarithromycin or Metronidazole: A Phase 1, Open-Label, Randomized, Crossover Study

<p><b>Article full text</b></p> <p><br></p> <p>The full text of this article can be found here<b>. </b><a href="https://link.springer.com/article/10.1007/s12325-016-0374-x">https://link.springer.com/article/10.1007/s12325-016-0374-x</a></p><p></p> <p><br></p> <p><b>Provide enhanced content for this article</b></p> <p><br></p> <p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”"><b>[email protected]</b></a>.</p> <p><br></p> <p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p> <p><br></p> <p>Other enhanced features include, but are not limited to:</p> <p><br></p> <p>• Slide decks</p> <p>• Videos and animations</p> <p>• Audio abstracts</p> <p>• Audio slides</p