免疫組織化学法による低分子医薬品の薬物動態研究

博士（工学）崇城大

An Image Registration Method for Head CTA and MRA Images Using Mutual Information on Volumes of Interest

Image registration is an important and a fundamental task in computer vision and image processing field. For example, to make a surgical plan for head operation, the surgeons should gain more detailed information from CT angiography (CTA) and MR angiography (MRA) images. And the abnormalities can be easily detected from the fusion image which is obtained from two different modalities. One of the multiple modal image registration methods is matching the CTA and MRA, by which the image of head vascular could be enhanced. In general, the procedure for fusion is completed manually. It is time-consuming and subjective. Particularly the anatomical knowledge is required as well. Therefore, the development of automatic registration methods is expected in medical fields. In this paper, we propose a method for high accurate registration, which concentrates the structure of head vascular. We use 2-D projection images and restrict volume of interests to improve the processing affection. In experiments, we performed our proposed method for registration on five sets of CTA and MRA images and a better result from our previous method is obtained.SCIS&ISIS 2014 : Joint 7th International Conference on Soft Computing and Intelligent Systems and 15th International Symposium on Advanced Intelligent, December 3-6, 2014, Kitakyushu, Japa

Study of Beam Profile Measurement at Interaction Point in International Linear Collider

At the international linear collider, measurement of the beam profile at the interaction point is a key issue to achieve high luminosity. We report a simulation study on a new beam profile monitor, called the pair monitor, which uses the hit distribution of the electron-positron pairs generated at the interaction point. We obtained measurement accuracies of 5.1%, 10.0%, and 4.0% for the horizontal, vertical, and longitudinal beam size, respectively, for 50 bunch crossings.Comment: 13 pages, 8 figures, 2 table

Experimental Evaluation of Learning Effect of Problem-Simplification for Self-overcoming of Failures: The Case of Music Rhythm Exercises

音楽リズム演奏課題を対象とした演習システムのために設計・開発した単純化方略による誤り克服支援機能の有効性を，この支援機能を用いた演習を受ける実験群と支援機能を用いない演習を受ける統制群を設け，実験的に調べたので報告する

Support for Self-Overcoming by Simplification in Rhythm Exercise and Its Experimental Evaluation

音楽演奏を対象とした学習支援システムの研究は，学習者が自身の誤りを自身で克服することを支援しているものが多く，その支援手法は演奏上の誤りを指摘し反復練習させるものが主であった．このような手法は，誤り箇所の指摘から自ら誤りを克服できるような学習者にしか有効でないと考えられる．そこで本研究では，課題の派生的成立モデルに基づき，基本的な音楽リズム課題を対象とした課題の単純化方略による誤りの自己克服支援システムを実現した．単純化方略では，学習者が解ける段階まで課題を単純化することで解ける課題と解けない課題の差分が誤りの原因として特定され，その差分を解ける課題に加えることで誤りの自己克服を促すような支援している．開発したシステムを用いて，単純化方略の効果を検証するための実験を行った．その結果，単純化方略による自己克服支援がリズム学習の演習法として有用であることを示唆する結果が得られた

An Image Registration Method for Head CT and MR Imaging Based on Optimal Retrieval

Image registration is an important problem and a fundamental task in com-puter vision and image processing field. Recently, many image registration techniques are introduced such as PET with CT image and abnormalities can be easily detected by using image information. One of the multi modal images, CT and MR imaging of the head for diagnosis and surgical planning indicates that physicians and surgeons gain impor- tant information from these modalities. In radiotherapy planning, manual registration techniques are performed on MR and CT images of the brain. In general, physicians segment the volumes of interest (VOIs) from each set of slices on the MR and CT im- ages manually. However, manual registration of the object may require several hours for analysis based on anatomical knowledge. In this paper, we describes a new method for automatic registration of head images which is obtained CT and MRI by using an optimal retrieval on neighbor VOIs in several extracted data and maximization of mutual information. In the experimental results, we can reduce the computational times. The primary objective of this study is to increase accuracy of the registration and reduce the computational processing time

Ureteral stent replacement in women

Purpose : To evaluate the efficacy of the direct grasping technique using pean forceps under fluoroscopic guidance for ureteral stent replacement in women. Methods : Between April 2018 and September 2020, 28 female patients underwent ureteral stent replacements at our facility, and 184 stent replacement procedures were performed. A total of 127 stents were replaced using pean forceps under fluoroscopic guidance (pean forceps group), and 57 stents were replaced using the cystoscope (cystoscopy group). Clinical characteristics and surgical outcomes were compared between the groups. Results : All stents were successfully replaced. There was a statistically significant difference in the procedure time between the two groups (median [interquartile range], pean forceps group : 10.8 [8.2–13.9] minutes vs. cystoscopy group : 15.8 [11.1–20.9] minutes, P < 0.001). There were no intraoperative complications in either group and no difference in the incidence of postoperative complications (pean forceps group : 1.6% vs. cystoscopy group : 1.8%, P = 1.000). Fluoroscopy time was longer in the pean forceps group, although this difference was not statistically significant (pean forceps group : 38.9 [22.6–60.1] seconds vs. cystoscopy group : 33.0 [20.0–48.9] seconds, P = 0.0558). Conclusion : The direct grasping technique using pean forceps under fluoroscopy may be a beneficial alternative to cystoscopy for ureteral stent replacement in women