Lexico-semantic structure of set expression with component "clothing" in typologically different languages

Nowadays phraseology represents one of the fields of research that arouses scientific interest on various aspects. The article is devoted to the classification of the Tatar and English set-expressions with «clothing» component in view of nine basic lexical-semantic groups. On this basis we reveal expressive degree of national-cultural component in the semantics of the researched units. Also the paper views in detail each group, their structure and more interesting examples of usage of these lexemes as part of phraseological and pareomiological units. The research gives the opportunity to reveal both lingual and cultural individuality of the Tatar and English linguocultures in the context of human's material-spiritual activity. The analysis allows not only systematizing taken during the investigation set-expressions but also determining similar and different linguistic and cultural characteristics of the researched linguocultures on the example of set-expressions with «clothing» component. The research results can be used for theoretical and practical courses in intercultural communication, comparative phraseology and pareomiology, linguofolklor

A process approach to management of an educational organization

© 2015, Review of European Studies. All right reserved. Directions for an educational organization development meet the requirements of society to the effectiveness and quality of educational activities in high dynamics of external and internal environment. The article examines the potential of the process approach, which considers management as a continuous performance of certain interrelated activities complex and general management functions when developing a quality management system of an educational organization. In the submitted article the components of the educational activities process are defined, which are based on the quality standard of the final product. This article is intended for educators, researchers, heads of educational institutions, employers, customers of educational services, education management organizations employees

Clinical Effectiveness of the Fixed‐Dose vs Free‐Dose Triple Combinations in Patients with Uncontrolled Arterial Hypertension

Background: The purpose of our study was a comparative assessment of the antihypertensive effectiveness of 2 triple combination antihypertensive therapy (AHT) regimens in a free-dose and fixed-dose combination of perindopril, indapamide, and amlodipine in hypertensive patients with high cardiovascular risk and a poor response to the 2-drug combinations in the clinic practice. Methods and Results: Our study included 143 patients (79 men and 88 women) with arterial hypertension (AH) Grades 1-3 (ESC/ESH, 2018) and high cardiovascular risk who did not achieve the target blood pressure (TBP) on dual combination AHT. The mean age of patients was 55.76±9.35 years; the average duration of AH was 10.69±6.61 years. All patients underwent the examinations according to the 2018 ESC/ESH Guidelines for the management of arterial hypertension. Patients included in the study were divided into 2 groups using the envelope method: Group 1 (n=84) received a fixed-dose, triple combination of perindopril, indapamide, and amlodipine; Group 2 (n=83) received a free-dose combination of these drugs. In both groups, treatment began after discontinuation of previous therapy, with a low dose of a triple combination of antihypertensive drugs (perindopril [5 mg/day], indapamide [1.25 mg/day], amlodipine [5 mg/day]) in the form of a fixed or free combination. The initial doses of perindopril/indapamide/amlodipine in both groups were not statistically different: 6.9±2.4/1.74±0.6/7.1±2.4mg/day in Group 1 and 6.9±2.7/1.95±0.6/7.1±2.5 mg/day in Group 2. After 4 weeks of therapy, if necessary, the doses of drugs were increased, starting with perindopril; the next adjustment of drug doses was carried out after 12 weeks of therapy. The final treatment results were determined after 24 weeks of AHT. Target blood pressure (TBP) of <140/90 mmHg was reached by 94.4% of patients in Group 1 and 83.3% in Group 2 (χ²=7.471, Р=0,006); TBP of <130/80 mmHg was reached by 70% of patients in Group 1 and 42% in Group 2 (χ²=11.61, Р=0,0001). A significant improvement in the diurnal BP profile was also revealed during treatment. According to ABPM data, both groups achieved TBP in terms of the average 24-h and average daytime systolic blood pressure (SBP) and diastolic blood pressure (DBP). Regarding average nighttime SBP and DBP and normalization of average nighttime diastolic blood pressure variability, target values were achieved only in Group 1(P=0.028). In both groups, 24-week triple-combination therapy led to a significant decrease in central SBP, central DBP, and pulse wave velocity (PWV). At the same time, the positive dynamics of central SBP were more pronounced in Group 1 than in Group 2 (Table 4), and PWV in Group 1 reached standard values. Conclusion: The results of our study showed that in the treatment of uncontrolled hypertension on previous therapy in AH patients with high cardiovascular risk, a single-pill triple combination of the ACEI perindopril, the CCB amlodipine, and the thiazide-like diuretic indapamide contributed to the effective daily blood pressure control, the improvement of diurnal blood pressure profile, and a positive effect on central blood pressure and PWV, thereby having a positive impact on the prognosis and quality of life of AH patients with high cardiovascular risk

Structure of the 70S ribosome from human pathogen Staphylococcus aureus

© 2016 The Author(s).Comparative structural studies of ribosomes from various organisms keep offering exciting insights on how species-specific or environment-related structural features of ribosomes may impact translation specificity and its regulation. Although the importance of such features may be less obvious within more closely related organisms, their existence could account for vital yet species-specific mechanisms of translation regulation that would involve stalling, cell survival and antibiotic resistance. Here, we present the first full 70S ribosome structure from Staphylococcus aureus, a Gram-positive pathogenic bacterium, solved by cryo-electron microscopy. Comparative analysis with other known bacterial ribosomes pinpoints several unique features specific to S. aureus around a conserved core, at both the protein and the RNA levels. Our work provides the structural basis for the many studies aiming at understanding translation regulation in S. aureus and for designing drugs against this often multi-resistant pathogen

Clinical and radiographic evaluation of optical density of bone tissue in the center of destruction of chronic apical periodontitis

The purpose of the complex examination was to determine the optical density of bone tissue in the periapical region in the focus of destruction in chronic apical periodontitis of masticatory groups of teeth in young people using methods of radiovisiography and dental computed tomography. To determine the parameters of optical density in the destruction center, 50 sighting images and 18 – dental computer tomograms were performed using radio – imaging data. 68 people aged 20 – 30 years, with various forms of chronic apical periodontitis without endodontic intervention in the anamnesis were examined. Based on the results of the study, there is a significant decrease in optical density in the focus of destruction, which indicates a significant decrease in bone density in the periapical region in chronic periodontitis, obtained by radiovisiography and dental computed tomography were reduced by 2 times compared to the norm. These data should be taken into account when monitoring the treatment of chronic apical periodontitis.Целью комплексного обследования явилось определение показателей оптической плотности костной ткани в периапикальной области в очаге деструкции при хроническом апикальном периодонтите жевательных групп зубов у лиц молодого возраста с помощью методов радиовизиографии и дентальной компьютерной томографии. Для определения параметров оптической плотности в очаге деструкции проводили по данным радиовизиографии – 50 прицельных снимков и 18 – дентальных компьютерных томограмм. Обследовано 68 человек в возрасте 20 – 30 лет, с различными формами хронического апикального периодонтита без эндодонтического вмешательством в анамнезе. Исходя из результатов исследования, отмечается значительное снижение оптической плотности в очаге деструкции, что свидетельствуют о значительном снижении костной плотности в периапикальной области при хроническом периодонтите, полученные методами радиовизиографии и дентальной компьютерной томографии были снижены в 2 раза по сравнению с нормой. Эти данные необходимо учитывать при мониторинге лечения хронического апикального периодонтита

Erratum: Structure of the 70S ribosome from human pathogen Staphylococcus aureus (Nucleic Acids Research (2017) DOI: 10.1093/nar/gkw933)

© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.The authors wish to correct their Funding statement as follows: FUNDING. 'Centre National de la Recherche Scientifique' (CNRS) and the 'Agence Nationale de la Recherche' as part of the 'Investissements d'Avenir' program [LabEx: ANR-10-LABX-0036-NETRNA to P.R., Y.H.; ANR-15-CE11-0021-01 to G.Y.]; 'Fondation pour la Recherche Médicale en France' [FDT20140930867 to I.K; 'European Research Council advanced grant' [294312 to M.Y.]; the 'Russian Science Foundation' [Project No. 16-14-10014 to I.K., M.Y.]. Funding for open access charge: Centre National de la Recherche Scientifique (CNRS). In addition, Marat Yusupov is associated with both affiliations1 and 2. The authors apologise to the readers for this error

EXPERIENCE OF ORGANIZING THE PREVENTING MEASURES FOR «ATYPICAL PNEUMONIA» DELIVERY AND SPREADING IN KRASNOYARSK TERRITORY

Analysis of measures for preventing the delivery and spreading of «atypical pneumonia» in Krasnoyarsk region is presented. Effect of counteracting with this infectious disease of the executive authority organs, State Surveillance service, public health and other interested institutions is emphasized. Further preventing measures against «atypical pneumonia» are determined

Doing Gender Online : Digital Spaces for Identity Politics

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