1 research outputs found
Expansion of Antibacterial Spectrum of Muraymycins toward <i>Pseudomonas aeruginosa</i>
It
is urgent to develop novel anti-Pseudomonas agents that should
also be active against multidrug resistant <i>P. aeruginosa</i>. Expanding the antibacterial spectrum of muraymycins toward <i>P. aeruginosa</i> was investigated by the systematic structure–activity
relationship study. It was revealed that two functional groups, a
lipophilic side chain and a guanidino group, at the accessory moiety
of muraymycins were important for the anti-Pseudomonas activity, and
analogue <b>29</b> exhibited antibacterial activity against
a range of <i>P. aeruginosa</i> strains with the minimum
inhibitory concentration values of 4–8 μg/mL