Expansion of Antibacterial Spectrum of Muraymycins toward <i>Pseudomonas aeruginosa</i>

Abstract

It is urgent to develop novel anti-Pseudomonas agents that should also be active against multidrug resistant <i>P. aeruginosa</i>. Expanding the antibacterial spectrum of muraymycins toward <i>P. aeruginosa</i> was investigated by the systematic structure–activity relationship study. It was revealed that two functional groups, a lipophilic side chain and a guanidino group, at the accessory moiety of muraymycins were important for the anti-Pseudomonas activity, and analogue <b>29</b> exhibited antibacterial activity against a range of <i>P. aeruginosa</i> strains with the minimum inhibitory concentration values of 4–8 μg/mL