358 research outputs found

    Gold(I)-Catalyzed Cascade Cyclization of Anilines with Diynes: Controllable Formation of Eight-Membered Ring-Fused Indoles and Propellane-Type Indolines

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    Heterocycle-fused indoles or indolines are distributed widely in a variety of natural products, bioactive agents, and pharmaceuticals. Herein, we describe the development of gold-catalyzed cascade reactions of anilines with diynes to form eight-membered ring-fused indoles and propellane-type indolines, both of which proceed through an intramolecular 5-endo-dig hydroamination followed by an 8-endo-dig cycloisomerization. Controllable formation of eight-membered ring-fused indoles and propellane-type indolines was achieved through selection of the ligands and/or solvents. Protic solvents such as alcohols or IPr ligand favored the formation of eight-membered ring-fused indoles, whereas the use of Buchwald’s type ligands and/or nonpolar solvents gave propellane-type indoline predominantly. This reaction provides rapid access to two types of fused nitrogen heterocycles from simple aniline derivatives

    Chiral symmetry restoration, eigenvalue density of Dirac operator and axial U(1) anomaly at finite temperature

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    We reconsider constraints on the eigenvalue density of the Dirac operator in the chiral symmetric phase of 2 flavor QCD at finite temperature. To avoid possible ultra-violet(UV) divergences, we work on a lattice, employing the overlap Dirac operator, which ensures the exact "chiral" symmetry at finite lattice spacings. Studying multi-point correlation functions in various channels and taking their thermodynamical limit (and then taking the chiral limit), we obtain stronger constraints than those found in the previous studies: both the eigenvalue density at the origin and its first and second derivatives vanish in the chiral limit of 2 flavor QCD. In addition we show that the axial U(1) anomaly becomes invisible in susceptibilities of scalar and pseudo scalar mesons, suggesting that the 2nd order chiral phase transition with the O(4) scaling is not realized in 2 flavor QCD. Possible lattice artifacts when non-chiral lattice Dirac operator is employed are briefly discussed.Comment: 39 pages, 1 figure(2 eps files), a version published in PR
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