Studying the Impact of the genetic polymorphisms of chemokines on the arterial pressure level and kidney function in patient with the chronic glomerulonephritis

It has been established that the genetic marker А I-TAC (rs 4512021) is the risk factor for genesis of the severe arterial hypertension at the chronic glomerulonephritis (OR=1,65) and the genotypes АА and AG I-TAC are the risk factors of depression of the kidney functio

Chemokines Genetic Variants are Associated with Parameters of Humoral Immunity of Patients with Chronic Glomerulonephritis

The authors researched associations of chemokines genes polymorphisms with parameters of humoral immunity of 238 patients with chronic glomerulonephritis and 462 individuals of a control grou

Electrochemical impedance spectroscopy of organic polyiodides with different anion composition and proton disorder

Funding for this research was provided by the Ministry of Education and Science 4.1157.2017/4.6

Optical Absorption and Raman Spectroscopy Study of the Fluorinated Double-Wall Carbon Nanotubes

Double-wall carbon nanotube (DWNT) samples have been fluorinated at room temperature with varied concentration of a fluorinating agent BrF3. Content of the products estimated from X-ray photoelectron data was equal to CF0.20 and CF0.29 in the case of deficit and excess of BrF3. Raman spectroscopy showed considerable decrease of carbon nanotube amount in the fluorinated samples. Analysis of optical absorption spectra measured for pristine and fluorinated DWNT samples revealed a selectivity of carbon nanotube fluorination. Nanotubes with large chiral angle are more inert to the fluorinating agent used

Polymeric hybrid iodoplumbates and iodobismuthates containing mono- and bisalkylated derivatives of 1,2-bis(4-pyridyl)ethylene: Structural and optical features

© 2017 Elsevier B.V.Reactions of PbI2 with N-alkylated derivatives of 1,2-bis(4-pyridyl)ethylene (bpen) MeBpenI and Me2BpenI2 result in 1D-polymeric complexes [{Pb(MeBpen)I3}] (1) and (Me2bpen)[{PbI3}]2 (2). For both compounds, band gap values were determinated experimentally; 1 demonstrates weak red luminescence. Binuclear hybrid iodobismuthate [Bi2(MeBpen)2I8] (3) was obtained by the similar scheme using BiI3 instead of PbI2

Prevalence of Listeria monocytogenes in meat products during 2017–2019 depending on technological factors and seasons

Microbiological examination of contamination of imported and domestic meat products with pathogenic bacteria Listeria monocytogenes depending on a meat type, technology and season was carried out during 2017–2019. In total, 2777 product samples were analyzed; the presence of this pathogen was revealed in 8.8% of products (244 positive samples). It was found that the prevalence of L. monocytogenes in meat products increased over three years of observation (2017–2019). The highest occurrence of this pathogen was found in poultry meat (on average 18.7%) followed by products from beef (13.2%). Meat products from mixed raw materials (beef and pork) accounted for 5.3% of tested samples, while in pork semi-finished products L. monocytogenes was found only in 3.2% of cases. It was noted that the technology of semi-finished products significantly affected the level of contamination of meat products with L. monocytogenes. Various technological approaches are used in the production process increasing the risk of contamination of the finished product since there is no timely data on Listeria contamination of raw materials used for production of a particular product. It has been established that a significant role in microbiological studies is played by various approaches to sample preparation of analyzed samples of meat cuts, semi-finished products in large and small pieces, as well as minced semi-finished products. Not knowing the real level of surface contamination with L. monocytogenes of carcasses, half-carcasses, semi-finished products in large pieces, manufacturers use such raw materials for the subsequent production of other types of semi-finished meat products, increasing the risk of manufacturing unsafe products with following contamination of equipment, work surfaces and other objects of the production environment. The highest occurrence of L. monocytogenes in meat products during three years of observation was found in the summer period (14.2%). The proportions of positive samples in the winter, spring and autumn months varied on average within 6.7–7.1%

ВЛИЯНИЕ КАПИЛЛЯРНОГО ДАВЛЕНИЯ В ПУЗЫРЬКАХ НА ИХ ПРИЛИПАНИЕ К ЧАСТИЦАМ ПРИ ПЕННОЙ ФЛОТАЦИИ

Calculation of the energy possibility of А spherical bubble transition into М captive bubble, i.e. А → М transition, has shown the great effect of capillary pressure (Рc) on the calculation results as well as that in reducing А and М bubbles and growing Рc in them, the range of possible РcМ change in М bubble is sharply confined and the effect of РcМ on the energy barrier along the path of the bubble adhesion to the hydrophilic surface drops practically to zero but the preference in bubble adhesion to the hydrophobic surface is kept constant, although the difference considerably drops compared with large bubbles. The practical data of the first processes of the foam flotation with microbubbles are the confirming experimental base of the results of this high-precision calculation. It is apparently, the adhesion process in practice is also promoted by θМ wetting angle reduction down to 0,02° and the beginning growth of spreading coefficient of the adhered bubble over the substrate-particle.Расчет энергетической возможности перехода сферического пузырька А в прилипший пузырек М, или перехода А → М (ПАМ), показал, сколь велико влияние величины капиллярного давления (Рк) на результаты расчета, а также то, что с уменьшением пузырьков А и М и ростом Рк в них диапазон возможного изменения РкМ в пузырьке М резко сужается, влияние РкМ на энергетический барьер на пути прилипания пузырька к гидрофильной поверхности падает практически до нуля, но предпочтение в прилипании пузырьков к гидрофобной поверхности сохраняется, хотя разница заметно снижается по сравнению с крупными пузырьками. Подтверждающей экспериментальной базой результатов этого прецизионного расчета являются данные практики первых процессов пенной флотации микропузырьками. Процессу прилипания на практике, по-видимому, также способствуют уменьшение краевого угла θМ до 0,02° и начинающийся рост коэффициента растекания прилипшего пузырька по подложке-частице

Molekular-genetic markers citokines: population prevalence and communication with the multifactorial pathology

Research objective: the analysis of distribution of frequencies alleles and genotypes of molekular-genetic markers citokines at patients with multifactorial pathology. The analysis of DNA-markers was carried out by means of standard molecular and population-genetic methods. It is established that the most widespread genotypes both at patients with multifactorial pathology, and in the control are-308GG TNF α and-471CC RANTES

NOVOSIBIRSK REGION PROGRAM OF THE LIVER TRANSPLANTATION IN CHILDREN

The aim of the study was to analyze the early and late outcomes of pediatric liver transplantation (LTx) program in the Novosibirsk region. Material and Methods. The retrospective study included 24 patients aged 72 ± 74.8 months (from 4 to 212 months, median – 20 months) with a body weight of 21.7 ± 18.1 kg (from 4.5 to 55 kg, median – 12.5 kg). Two (8.3 %) cadaveric whole liver grafts, 19 (79.2 %) living donor liver grafts, and 3 (12.5 %) cadaveric liver fragments (reduced-size or split-liver) were transplanted. Results. The features of vascular and biliary reconstruction in different types of LTx are discussed. The incidence of vascular and biliary complications was 8.3 and 20.8%, respectively. The patients stayed in the intensive care unit for 9 ± 5.1 days (from 4 to 22 days, median 8 days) and total length of hospital stay was for 40 ± 25.4 days (from 19 to 136 days, median 32 days). Two (8.3 %) recipients had early graft dysfunction. Perioperative mortality (up to 90 days) was absent. The overall 5-year patient and graft survival rates were 95 and 88 %, respectively. Conclusion. The Novosibirsk region has a pediatric LTx program with outcomes comparable to the data of the leading world and Russian centers

Дифиллоботриоз: вопросы диагностики, терапии, профилактики

Helminthiases are found in the group of the most common and socially significant human infectious diseases. According to current data, at least 1 billion people are infected with helminths or pathogenic infections. One of the most important and widespread human biohelminth parasites in the Russian Federation is the broad-spectrum tapeworm (Diphyllobothrium latum). The absence of specific clinical diagnosis, as well as the predominance of latent forms, determines the presence of diphyllobothriasis disease. The aim of the study was to summarize current data on the epidemiology, pathogenesis, clinical and laboratory manifestations and therapy of diphyllobothriasis.  Materials and methods. Clinical cases of diphyllobothriasis were analyzed among patients who were treated in January to November 2022 in the departments of the daytime period of clinical observation of the infectious diseases hospital named after S.P. Botkin, as well as the department of incidents detected and the clinical diagnostic center of Pediatric Research and Clinical Center for Infectious Diseases. Cases of the use of diseases, data from laboratory and instrumental studies, and therapy were evaluated. The most informative of them is given as a clinical example. The article also describes in detail the current biological and epidemiological features of Diphyllobothrium latum, the characteristic clinical picture of diseases and the most frequent complications.  Results. Diphyllobothriasis still remains one of the most vulnerable biohelminthiases in Russia, typical for some patients of different ages. Verification of the diagnosis of “diphyllobothriasis” can be of the nature of an “accidental finding” during screening scatological or instrumental studies; upon admission, patients themselves begin to suspect helminthiasis when fragments of the strobila worm are found in the feces. To identify a conditional diagnosis of the pattern of clinical and laboratory infection (exclusion of a complicated course of diseases, helminthiases of a different etiology) and to determine risk factors for the transmission of diseases for the prevention of infections. Гельминтозы составляют группу наиболее распространенных и социально значимых инфекционных заболеваний человека. По современным данным, не менее 1 миллиарда людей инфицированы гельминтами или патогенными простейшими. Одним из наиболее крупных и широко распространённых в Российской Федерации биогельминтов-паразитов человека является лентец широкий (Diphyllobothrium latum). Отсутствие специфической клинической картины, а также преобладание латентных форм обусловливает трудности диагностики дифиллоботриоза. Цель: обобщение современных данных об эпидемиологии, патогенезе, клинико-лабораторных проявлениях и терапии дифиллоботриоза.  Материалы и методы. Проанализированы клинические случаи дифиллоботриоза среди пациентов, проходивших лечение в период с января по ноябрь 2022 г. в отделении дневного пребывания Клинической инфекционной больницы им. С.П. Боткина, а также в отделении кишечных инфекций и клинико-диагностическом центре Детского научно-клинического центра инфекционных болезней. Оценивались клинические проявления заболевания, данные лабораторных и инструментальных исследований, проводимая терапия. Наиболее информативный из них приведён в качестве клинического примера. В статье также подробно описаны актуальные биологические и эпидемиологические особенности Diphyllobothrium latum, характерная клиническая картина заболевания и наиболее частые осложнения.  Результаты. Дифиллоботриоз остается одним из наиболее распространённых биогельминтозов России, характерных для пациентов различных возрастов. Верификация диагноза «Дифиллоботриоз» может носить характер случайной находки при скриннинговых копрологических или инструментальных исследованиях, в ряде случаев пациенты сами начинают подозревать у себя гельминтоз при обнаружении в испражнениях фрагментов стробилы червя. Для установления окончательного диагноза целесообразно проведение клиниколабораторного обследования (исключение осложнённого течения заболевания, гельминтозов другой этиологии) и уточнения факторов риска передачи заболевания для профилактики повторных заражений.