Data from: Association of diabetic retinopathy and diabetic macular edema with renal function in southern Chinese patients with type 2 diabetes mellitus: a single-center observational study

Background and Objectives: The association of diabetic retinopathy (DR) and diabetic macular edema (DME) with renal function in southern Chinese diabetic patients is poorly understood. So we aimed to study the correlation between stage of DR and DME with stage of eGFR (estimated glomerular filtration rate) and stage of UACR (urine albumin to creatinine ratio), and to explore the systemic risk factors for DR and DME. Design and Setting: Single-center retrospective observational study. Participants: 413 southern Chinese patients with type two diabetes mellitus (T2DM). Outcome Measures: The correlations between stage of DR and DME with stage of eGFR/UACR were assessed by spearman or Χ² analyses and represented with histograms. Risk factors associated with the occurrence of DR and DME were performed by logistic regression and represented with nomograms. Results: Stage of DR had a positive correlation with stage of eGFR (r=0.264, p＜0.001) and stage of UACR (r=0.542, p＜0.001). With the stage of eGFR/UACR being more severe, the prevalence of DME became higher as well (both p＜0.001). The risk factors for DR were DM duration (OR, 1.072; 95% CI, 1.032–1.114; P＜0.001), stage of UACR (OR, 2.001; 95% CI, 1.567-2.555; P＜0.001) and LDL (OR, 1.301; 95% CI, 1.139-1.485; P＜0.001), while risk factors for DME were stage of UACR (OR, 2.308; 95% CI, 1.815-2.934; P＜0.001) and LDL (OR, 1.460; 95% CI, 1.123–1.875; P=0.008). Conclusions: Among southern Chinese patients, stage of DR and DME were positively correlated with renal function, while stage of UACR performed a better relevance than stage of eGFR