Copper-catalyzed efficient dithiocyanation of styrenes: Synthesis of dithiocyanates

<p>A novel Cu-catalyzed intermolecular chemoselectivity dithiocyanation of styrenes with ammonium thiocyanate has been developed under mild conditions. This reaction exhibits a wide range of functional-group tolerance in styrenes to afford various dithiocyanates. The reaction mechanism was primarily investigated and a radical process was proposed.</p

Cu-Catalyzed Aminodifluoroalkylation of Alkynes and α‑Bromodifluoroacetamides

The copper-catalyzed highly regioselective aminodifluoroalkylation of alkynes and α-bromodifluoroacetamides was realized for the first time. With this method, 3,3-difluoro-1<i>H</i>-pyrrol-2­(3<i>H</i>)-ones were constructed in a single step from various alkynes and α-bromodifluoroacetamides substrates without using any extra oxidant

Ruthenium-Catalyzed <i>ortho</i>/<i>meta</i>-Selective Dual C–H Bonds Functionalizations of Arenes

The first example of transition-metal-catalyzed <i>ortho</i>/<i>meta</i>-selective dual C–H functionalizations of arenes in one reaction is described. In this transformation, <i>ortho</i>-C–H chlorination and <i>meta</i>-C–H sulfonation of 2-phenoxypyri­(mi)­dines were achieved simultaneously under catalysis by [Ru­(<i>p</i>-cymene)­Cl₂]₂. The other reactant, namely, an arylsulfonyl chloride, played the role of both a sulfonation and chlorination reagent. More importantly, the arylsulfonyl chloride was also an oxidant in the process. Mechanistic studies indicated that six-membered ruthenacycles were the key intermediate in the reaction

Regioselective, Molecular Iodine-Mediated C3 Iodination of Quinolines

A novel and convenient method has been developed for the regioselective iodination of quinolines at their C3 position under metal-free conditions. Iodinated quinolines, which are popular building blocks in organic and medicinal chemistry, can be prepared in gram quantities and good yields using this method and further derivatized to give increasingly complex compounds. Preliminary mechanistic studies have shown that this reaction most likely occurs via a radical intermediate