Regioselective, Molecular Iodine-Mediated C3 Iodination
of Quinolines
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Abstract
A novel and convenient
method has been developed for the regioselective
iodination of quinolines at their C3 position under metal-free conditions.
Iodinated quinolines, which are popular building blocks in organic
and medicinal chemistry, can be prepared in gram quantities and good
yields using this method and further derivatized to give increasingly
complex compounds. Preliminary mechanistic studies have shown that
this reaction most likely occurs via a radical intermediate