Trehalose alleviates human podocyte injury via the induction of autophagy in an mTOR independent manner

Conference Theme: Excellence through collaborationThis journal issue contain abstracts of the 12th Asian Congress of Pediatric Nephrology (pp.2425-2445)postprin

DECODE: An integrated differential co-expression and differential expression analysis of gene expression data

2014-2015 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Coexpression pattern analysis of NPM1-associated genes in chronic myelogenous leukemia

2014-2015 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Gene network exploration of crosstalk between apoptosis and autophagy in chronic myelogenous leukemia

2014-2015 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Genetic association between germline JAK2 polymorphisms and myeloproliferative neoplasms in Hong Kong Chinese population : a case–control study

2014-2015 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

MicroRNA-mediated alteration of TET2 interaction network in myeloproliferative neoplasms

2011 IEEE 13th International Conference on e-Health Networking, Applications and Services, HEALTHCOM 2011, Columbia, MO, 13-15 June 2011Myeloproliferative neoplasms (MPNs) constitute a type of proliferative and dysplastic myeloid tumors, which are frequently found in the elderly people. Although some kinds of gene mutations in MPNs have been studied, the biological mechanisms behind this disease are still not very clear. Researchers have found that MPN patients with TET2 mutations have low level of 5hmC. However, they do not give reasons why there is also low level of 5hmC in patients with wild-type TET2. The aim of this study is to investigate into the role of TET2 and its interacting proteins in MPN under the repression by microRNAs. MicroRNAs are short, endogenous, non-coding RNA molecules, which regulate the target genes expression. We hypothesize that microRNAs lead to low level of 5hmC by down-regulating the expression of TET2 and other proteins interacting with TET2 in MPN patients with wild-type TET2, which is similar to the function of TET2 mutations. Bioinformatics tools were performed in this study. There were 11 databases considered, only 3 of which predicted microRNAs binding to TET2. Moreover, 10 proteins were found to be associated with TET2 according to STRING database and their targeting miRNA predictions was compared with that of TET2. The hypothesis can be supported by he predicted simultaneous repression of DNMT-1 and TET2 by miR-152.Department of Health Technology and InformaticsRefereed conference pape

Multiple regression analysis of mRNA-miRNA associations in colorectal cancer pathway

2013-2014 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Novel approach for coexpression analysis of E2F1-3 and MYC target genes in chronic myelogenous leukemia

2014-2015 > Academic research: refereed > Publication in refereed journalpublished_fina