2014-2015 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Chan, LWC

Cho, WCS

Siu, PM

Tsui, NBY

Wang, F

Wong, SCC

Yip, SP

Yung, BYM

BioMed Research International

2014-2015 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishedC

PolyU Institutional Repository

Gene network exploration of crosstalk between apoptosis and autophagy in chronic myelogenous leukemia

Background. Gene expression levels change to adapt the stress, such as starvation, toxin, and radiation. The changes are signals transmitted through molecular interactions, eventually leading to two cellular fates, apoptosis and autophagy. Due to genetic variations, the signals may not be effectively transmitted to modulate apoptotic and autophagic responses. Such aberrant modulation may lead to carcinogenesis and drug resistance. The balance between apoptosis and autophagy becomes very crucial in coping with the stress. Though there have been evidences illustrating the apoptosis-autophagy interplay, the underlying mechanism and the participation of the regulators including transcription factors (TFs) and microRNAs (miRNAs) remain unclear. Results. Gene network is a graphical illustration for exploring the functional linkages and the potential coordinate regulations of genes. Microarray dataset for the study of chronic myeloid leukemia was obtained from Gene Expression Omnibus. The expression profiles of those genes related to apoptosis and autophagy, including MCL1, BCL2, ATG, beclin-1, BAX, BAK, E2F, cMYC, PI3K, AKT, BAD, and LC3, were extracted from the dataset to construct the gene networks. Conclusion. The network analysis of these genes explored the underlying mechanisms and the roles of TFs and miRNAs for the crosstalk between apoptosis and autophagy.Department of Health Technology and Informatic

The Hong Kong Polytechnic University Pao Yue-kong Library

Gene network exploration of crosstalk between apoptosis and autophagy in chronic myelogenous leukemia

Abstract

Similar works

Full text

Available Versions

PolyU Institutional Repository

The Hong Kong Polytechnic University Pao Yue-kong Library