Prospek Tanaman Obat sebagai Antihepatitis

Hepatitis remains a serious global health problem because of the potential impact to morbidity and mortality. Prevalence of hepatitis patients in Indonesia either by viral infection or noninfection increases rapidly. The high cost of treatment hepatitis resulted in the switch in the use medicinal plants to cope with this disease. Several types of medicinal plants were proven to be antihepatitis such as meniran, temulawak, mengkudu and pegagan. The objective of this paper is to provide scientific information study of medicinal plants useful as antihepatitis and their development prospect. The method used in this study is to review the relevant scientific articles in international and national journals. Based on reference studies it has been reported that meniran, temulawak, mengkudu and pegagan have a great potential and prospective as antihepatitis drugs. The important challenge in development of medicinal plants is a constant quality as well as, continuous supply of raw materials and effect assured

Optimasi Formula Tablet Salut Enterik Natrium Diklofenak dengan Bahan Penyalut Kollicoat 30 D

Diclofenac sodium is an analgetic and antiinflammation drug and commonly used by oral administration. Because of it’s side effects that can cause stomach irritation, nausea and vomiting, it’s made in the form of enteric-coated. Enteric-coated formulations developed used organic solvent having toxicity and flammability risks. The aim of this study is to develop diclofenac sodium enteric-coated tablets with a water-based coating material. Coating material used is Kollicoat 30 D which is a derivative of acrylic polymer that can dispersed in water. Optimalization of the formula is done by the weight gain 4%, 6% and 8%. The result showed that enteric coated tablets used coating material with weight gain 8% gave the best result with all parameters meet the requirements of the test, there was no change in acid medium for 2 hours and stable released active ingredient in alkaline medium

Revitalisasi Obat Generik: Hasil Uji Disolusi Obat Generik Tidak Kalah Dengan Obat Bermerek

The government through the Ministry of Health is very serious about revitalizing the use of generic medicines by issuing a policy that stipulated in the Regulation of the Minister of Health No. HK. 02.02/Menkes/068/1/2010 about duty to use generic medicines in government health care facilities. To maximize the use of generic medicines, it is very important to improve the understanding and trust of society that the quality, safety and effectiveness of generic medicines are similar to branded medicines. In addition, if there many researchs and the studies of generic medicines, they would increase the knowledge of health professionals, especially doctors, they may not hesitate to prescribe generic medicines. Since the quality as a basis of reference to establish the truth of the eficacy and safety, while the availability of certain products can be demonstrated in vitro. Studies of medicines dissolution, can give the same indication with medicines bioavailability. Ideally, in vitro medicines dissolution correlates bioavailability in vivo. The researchs results of dissolution test generic medicines of Amoxiciline 500 mg tablets, Isosorbit Dinitrat 5 mg tablets and Omeprazole capsules show that generic medicines have a better dissolution test results when compared to branded medicines

Optimasi Formula Tablet Salut Enterik Natrium Diklofenak Dengan Bahan Penyalut Kollicoat 30 D

Diclofenac sodium is an analgetic and antiinflammation drug and commonly used by oral administration. Because of it's side effects that can cause stomach irritation, nausea and vomiting, it's made in the form of enteric-coated. Enteric-coated formulations developed used organic solvent having toxicity and flammability risks. The aim of this study is to develop diclofenac sodium enteric-coated tablets with a water-based coating material. Coating material used is Kollicoat 30 D which is a derivative of acrylic polymer that can dispersed in water. Optimalization of the formula is done by the weight gain 4%, 6% and 8%. The result showed that enteric coated tablets used coating material with weight gain 8% gave the best result with all parameters meet the requirements of the test, there was no change in acid medium for 2 hours and stable released active ingredien

Formulation of Peperomia Pellucida (L) Kunth Extract Tablet by Modified Filler

Background: Peperomia pellucida has been widely used in traditional medicine. Recently, its existing forms are still conventional such as juice and infusum; therefore, it needs to be formulated more practically and in uniform weight such as tablet form. The objective of this research was to get the optimum formula of P. pellucidaextract tablet. Methods: P. pellucida extract tablets were produced with variation of microcrystalline cellulose (MCC) PH 101 – lactose by wet granulation method in three formulas, formula I (100% MCC PH 101), II (lactose 100%), and III (MCC PH 101: lactose = 50%: 50%). Granules were evaluated their physical characteristics including their flow rate, water absorption and compactibility to obtain the optimum formula by using simplex lattice design and total response. The optimum formula was used to make tablet and tested its physical characteristics (uniformity weight, hardness, and friability and disintegration time). Results:Lactose significantly influenced by its flow rate, whereas MCC PH 101 influenced the compactibility and water absorption. Based on the granules physical characteristics and their total responses, the formula combination of MCC PH 101 80% and lactose 20% was concluded to be the most optimum one for tablet filler. This optimum formula tablet had the best physical characteristics with weigth uniformity of 620.84 ± 1.04 mg, hardness of 8.54 ± 0.68 kg, friability of 0.26% ± 0.04 and disintegration time of 4.58 ± 0.17 minutes. Conclusion: The proportion MCC PH 101 80% and lactose of 20% obtained the best optimum formula and passed requirements of the tablet physical characteristics. (Health Science Indones 2013;1:32-6

Quantitative Analysis of Bioactive Compounds in Extract and Fraction of Star Fruit (Averrhoa carambola L.) Leaves using High Performance Liquid Chromatography

Star fruit (Averrhoa carambola L.) is potential as raw material for medicine, native in tropic areas, including Indonesia. According to other study report, star fruit leaves containing flavonoids apigenin and quercetin as potential anti-inflammatory and anticancer agents. The raw material for the drug in Indonesia mostly obtained through imports from other countries. In order to support the independence of traditional medicine raw materials, it is important to standardize the quality of traditional medicine raw materials, in this case is star fruit leaves by High Performance Liquid Chromatography (HPLC) method. The sample used is star fruit leaves extract obtained from maceration process using ethanol 70%; water fraction, ethyl acetate and hexane fractions obtained from fractionation process of the ethanolic extract. Physical parameters analyzed in sample include appearance, color, odor, taste, extract yield, water content, loss of drying, total ash content, residual solvent. Chemical parameters analyzed include apigenin and quercetin contents. The results shows that star fruit leaves used in this study meet the standards of Indonesian Herbal Pharmacopoeia with highest apigenin (6.37%) and quercetin (4.49%) content are in ethyl acetate fraction

Effect of Purified Gambir Leaves Extract to Prevent Atherosclerosis in Rats

Background: Atherosclerosis is a risk factor for coronary heart disease (CHD). Catechin have highantioxidant activity that can prevent atherosclerosis. Gambir (Uncaria gambir, Roxb.) leaves extract havehigh catechin content thereby potentially inhibiting atherosclerosis. This research was aimed to examineeffect of purified gambir leaves extract to prevent atherosclerosis in rats.Methods: The experimental laboratory study was conducted in Pharmacy Laboratory and Animal Laboratory,National Institute of Health Research and Development, Ministry of Health, Republic of Indonesia in 2014.Gambir leaves extract were purified to gain optimum catechin. Afterwards, antioxidant activity was testedusing 2.2-diphenyl-1-picrylhydrazyl (DPPH) method, with ascorbic acid as positive control. Thirty six whitemale Sprague Dawley rats aged 2.5 months were randomly divided into six groups, i.e. normal control group,negative control group (aquadest), positive control group (atorvastatin 2 mg/200 g bw),extract dose I (20mg/200 g bw), dose II (40 mg/200 g bw) and dose III (80 mg/200 g bw). The rats were given high fat diet andtreatment according to their group for 60 days, except for normal control group.Results: Catechin content in the purified gambir leaves extract was 92,69%. From antioxidant activity test, IC50 wasfound to be 11,76 μg/mL. Anti-atherosclerotic activity study shown that compared to negative control, all three dosesof purified gambir leaves extract were able to prevent atherosclerosis through inhibition of aortic wall thickening andfoam cell formation due to high fat diet (p<0.05). Anti-atherosclerotic activity increased with increasing dose.Conclusion: Gambir leaves purified extract had the effect of preventing the thickening of the walls andfoam cell formation rat aorta. (Health Science Journal of Indonesia 2015;6:105-10