Formulation of Peperomia Pellucida (L) Kunth Extract Tablet by Modified Filler

Abstract

Background: Peperomia pellucida has been widely used in traditional medicine. Recently, its existing forms are still conventional such as juice and infusum; therefore, it needs to be formulated more practically and in uniform weight such as tablet form. The objective of this research was to get the optimum formula of P. pellucidaextract tablet. Methods: P. pellucida extract tablets were produced with variation of microcrystalline cellulose (MCC) PH 101 – lactose by wet granulation method in three formulas, formula I (100% MCC PH 101), II (lactose 100%), and III (MCC PH 101: lactose = 50%: 50%). Granules were evaluated their physical characteristics including their flow rate, water absorption and compactibility to obtain the optimum formula by using simplex lattice design and total response. The optimum formula was used to make tablet and tested its physical characteristics (uniformity weight, hardness, and friability and disintegration time). Results:Lactose significantly influenced by its flow rate, whereas MCC PH 101 influenced the compactibility and water absorption. Based on the granules physical characteristics and their total responses, the formula combination of MCC PH 101 80% and lactose 20% was concluded to be the most optimum one for tablet filler. This optimum formula tablet had the best physical characteristics with weigth uniformity of 620.84 ± 1.04 mg, hardness of 8.54 ± 0.68 kg, friability of 0.26% ± 0.04 and disintegration time of 4.58 ± 0.17 minutes. Conclusion: The proportion MCC PH 101 80% and lactose of 20% obtained the best optimum formula and passed requirements of the tablet physical characteristics. (Health Science Indones 2013;1:32-6