Learning Multi-Level Information for Dialogue Response Selection by Highway Recurrent Transformer

With the increasing research interest in dialogue response generation, there is an emerging branch formulating this task as selecting next sentences, where given the partial dialogue contexts, the goal is to determine the most probable next sentence. Following the recent success of the Transformer model, this paper proposes (1) a new variant of attention mechanism based on multi-head attention, called highway attention, and (2) a recurrent model based on transformer and the proposed highway attention, so-called Highway Recurrent Transformer. Experiments on the response selection task in the seventh Dialog System Technology Challenge (DSTC7) show the capability of the proposed model of modeling both utterance-level and dialogue-level information; the effectiveness of each module is further analyzed as well

Development of HIF-1α/HIF-1β heterodimerization inhibitors using a novel bioluminescence reporter assay system for in vitro high throughput screening and in vivo imaging

Tumor growth often outpaces its vascularization, leading to development of a hypoxic tumor microenvironment. In response, an intracellular hypoxia survival pathway is initiated by heterodimerization of hypoxia-inducible factor (HIF)-1α and HIF-1β, which subsequently upregulates the expression of several hypoxia-inducible genes, promotes cell survival and stimulates angiogenesis in the oxygen-deprived environment. Hypoxic tumor regions are often associated with resistance to various classes of radio- or chemotherapeutic agents. Therefore, development of HIF-1α/β heterodimerization inhibitors may provide a novel approach to anti-cancer therapy. To this end, a novel approach for imaging HIF-1α/β heterodimerization in vitro and in vivo was developed in this study. Using this screening platform, we identified a promising lead candidate and further chemically derivatized the lead candidate to assess the structure-activity relationship (SAR). The most effective first generation drug inhibitors were selected and their pharmacodynamics and anti-tumor efficacy in vivo were verified by bioluminescence imaging (BLI) of HIF-1α/β heterodimerization in the xenograft tumor model. Furthermore, the first generation drug inhibitors, M-TMCP and D-TMCP, demonstrated efficacy as monotherapies, resulting in tumor growth inhibition via disruption of HIF-1 signaling-mediated tumor stromal neoangiogenesis

An Empirical Study of Content Understanding in Conversational Question Answering

With a lot of work about context-free question answering systems, there is an emerging trend of conversational question answering models in the natural language processing field. Thanks to the recently collected datasets, including QuAC and CoQA, there has been more work on conversational question answering, and recent work has achieved competitive performance on both datasets. However, to best of our knowledge, two important questions for conversational comprehension research have not been well studied: 1) How well can the benchmark dataset reflect models' content understanding? 2) Do the models well utilize the conversation content when answering questions? To investigate these questions, we design different training settings, testing settings, as well as an attack to verify the models' capability of content understanding on QuAC and CoQA. The experimental results indicate some potential hazards in the benchmark datasets, QuAC and CoQA, for conversational comprehension research. Our analysis also sheds light on both what models may learn and how datasets may bias the models. With deep investigation of the task, it is believed that this work can benefit the future progress of conversation comprehension. The source code is available at https://github.com/MiuLab/CQA-Study.Comment: Published at AAAI 202

Shilling Black-box Review-based Recommender Systems through Fake Review Generation

Review-Based Recommender Systems (RBRS) have attracted increasing research interest due to their ability to alleviate well-known cold-start problems. RBRS utilizes reviews to construct the user and items representations. However, in this paper, we argue that such a reliance on reviews may instead expose systems to the risk of being shilled. To explore this possibility, in this paper, we propose the first generation-based model for shilling attacks against RBRSs. Specifically, we learn a fake review generator through reinforcement learning, which maliciously promotes items by forcing prediction shifts after adding generated reviews to the system. By introducing the auxiliary rewards to increase text fluency and diversity with the aid of pre-trained language models and aspect predictors, the generated reviews can be effective for shilling with high fidelity. Experimental results demonstrate that the proposed framework can successfully attack three different kinds of RBRSs on the Amazon corpus with three domains and Yelp corpus. Furthermore, human studies also show that the generated reviews are fluent and informative. Finally, equipped with Attack Review Generators (ARGs), RBRSs with adversarial training are much more robust to malicious reviews

Learning Resolution-Invariant Deep Representations for Person Re-Identification

Person re-identification (re-ID) solves the task of matching images across cameras and is among the research topics in vision community. Since query images in real-world scenarios might suffer from resolution loss, how to solve the resolution mismatch problem during person re-ID becomes a practical problem. Instead of applying separate image super-resolution models, we propose a novel network architecture of Resolution Adaptation and re-Identification Network (RAIN) to solve cross-resolution person re-ID. Advancing the strategy of adversarial learning, we aim at extracting resolution-invariant representations for re-ID, while the proposed model is learned in an end-to-end training fashion. Our experiments confirm that the use of our model can recognize low-resolution query images, even if the resolution is not seen during training. Moreover, the extension of our model for semi-supervised re-ID further confirms the scalability of our proposed method for real-world scenarios and applications.Comment: Accepted to AAAI 2019 (Oral

Well-differentiated gall bladder hepatoid carcinoma producing alpha-fetoprotein: a case report

<p>Abstract</p> <p>Introduction</p> <p>Gall bladder carcinoma is rare, and metastatic gall bladder carcinoma from hepatocellular carcinoma has been reported in only a few patients.</p> <p>Case presentation</p> <p>We present a 73-year-old man with a history of hepatitis B virus-related liver cirrhosis and hepatocellular carcinoma. He received transcatheter arterial chemoembolization, and was diagnosed to have an alpha-fetoprotein producing gall bladder tumor with intraluminal growth. Open cholecystectomy was performed. Pathologic examination of the lesion revealed a well-differentiated hepatoid carcinoma. The lesion was thought most likely to be a metastatic lesion from previous hepatocellular carcinoma. His alpha-fetoprotein level dropped to normal levels five months after the surgery.</p> <p>Conclusion</p> <p>This unusual intraluminal growing tumor proved to be a well-differentiated hepatoid carcinoma, most likely a metastatic lesion from previous hepatocellular carcinoma. This case reminds clinicians that in looking for likely hepatocellular carcinoma recurrence, when no detectable hepatic lesion can account for an elevated alpha-fetoprotein level, the gall bladder should be included in the search for the site of metastasis.</p