Overview and characterization of penile cancer content across social media platforms

BackgroundSocial media platforms (SMP) are an emerging resource that allows physicians, patients, and families to converse on cancer prevention, diagnosis, and treatment. We aimed to characterize penile cancer (PC) content shared on SMP.MethodsWe searched PC posts on Twitter, Facebook, and Instagram from July 1st, 2021, through June 30th, 2022. Two independent, blinded reviewers analyzed the hashtags: #PenileCancer, #PenileCancerAwareness, and #PenileNeoplasm. Descriptive statistics were used for posts characterization, Pearson´s correlation coefficient for associations, and Cohen’s weighted kappa coefficient for inter-rater agreement rate.ResultsA total of 791 posts were analyzed, with Twitter accounting for 52%, Facebook for 12.2%, and Instagram for 35.5%, and. Most posts originated from high-income countries, such as the United Kingdom (48.8%). We found no correlation between the number of posts with PC incidence (p = 0.64) or users on SMP (p = 0.27). Most accounts were classified as “support and awareness communities” (43.6%) and “physicians and clinical researchers” (38.2%). Urology was the most common medical specialty to post (60.9%), followed by oncology (11.3%). Most posts were classified as “prevention and awareness for users” (45.1%). Global inter-reviewer agreement rate was almost perfect (k=0.95; p ≤ 0.01). On Twitter, “physicians and clinical researchers” shared more content on “treatment updates and medical papers published in medical journals,” while on Facebook and Instagram, “support and awareness communities” focused on “personal and support comments.”ConclusionOverall, the number of PC posts was low compared to other neoplasms across the SMP evaluated in this study. “Physicians and clinical researchers” shared more content on Twitter, while “support and awareness communities” on Facebook and Instagram. Encouraging the use of a common SMP among the medical community and general users could lead to a more effective communication between physicians, patients, and support groups, and to increased awareness of PC

Etiología viral en adultos con infección respiratoria aguda grave en Colombia

Objetivo: Identificar la etiología viral en los pacientes adultos con infección respiratoria aguda grave (IRAG) admitidos en instituciones de vigilancia centinela en Bogotá durante el año 2012. Métodos: Estudio descriptivo de corte transversal en el que se emplearon técnicas de micromatrices moleculares para identificación viral en muestras de aspirado o hisopado nasofaríngeo de pacientes adultos con IRAG notificados al sistema de vigilancia epidemiológica y se realizó descripción de características clínicas y desenlaces clínicos relevantes como mortalidad, necesidad de UCI, ventilación mecánica y estancia hospitalaria. Resultados: Se analizaron 91 pacientes con IRAG y en 63 (69.2%) se logró identificación viral. La patología más frecuente encontrada fue el EPOC en el 24.2% de los pacientes. Los virus que se aislaron con más frecuencia fueron Influenza y Bocavirus en 30.8% y 28.6% de los casos, respectivamente. La mortalidad fue de 15.4%, ingreso a UCI ocurrió en 42.9%, requerimiento de ventilación mecánica en 36.3% y la estancia hospitalaria promedio fue de 9.9 días. El uso de antibiótico ocurrió en 90.1% de los pacientes. Conclusión: La prevalencia de la etiología viral en las infecciones respiratorias agudas graves, en este estudio fue alta, con desenlaces clínicos adversos, con requerimiento de cuidado intensivo y mortalidad elevada.Abstract. Objective: To identify the viral etiology in adult patients with severe acute respiratory infection (SARI) admitted to sentinel surveillance institutions in Bogotá in 2012. Methods: Cross sectional study in which microarray molecular techniques for viral identification were used on nasopharyngeal samples of adult patients reported SARI surveillance system and further description of clinical features and relevant clinical outcomes such as mortality, need for critical care, use of mechanical ventilation and hospital stay was performed. Results: 91 patients with SARI were analyzed and 63 (69.2%) achieved viral identification. The most frequent pathology found was COPD in 24.2% patients. The viruses isolated more frequently were influenza and bocavirus in 30.8% and 28.6% of cases, respectively. Mortality was 15.4%, admission to ICU was 42.9%, the requirement for mechanical ventilation was 36.3%, and the average hospital stay was 9.9 days. Antibiotics were used in 90.1% of patients. Conclusion: The prevalence of viral etiology of severe acute respiratory infections in this study was high, with adverse clinical outcomes, with intensive care requirement and high mortality.Otr

Análisis de la gestión financiera en la empresa Postobón de la ciudad de Ibagué a partir de sus estados financieros del segundo semestre del 2019

1. Introducción. -- 2. Objetivos. -- 2.1. Objetivo general. -- 2.2. Objetivos específicos. -- 3. Marco teórico. -- 4. Presentación de la empresa. -- 4.1. Política para la gestión integral del riesgo. -- 4.2. Política sarlaft. -- 5. Análisis de los estados financieros. -- 6. Administración del capital de trabajo. -- 6.1. Incremento del activo corriente. -- 6.2. Disminución del activo corriente. -- 6.3. Disminución del pasivo corriente. -- 7. Administración del efectivo. -- 7.1. Rotación. -- 8.1. Mejorar la rotación de inventario. -- 8.2. Mejorar la rotación de cartera. -- 8.3. Obtener mayor plazo con proveedores. -- 8.4. Aplicación de las 3 estrategias de manera conjunta. -- 9. Administración de la cartera. -- 9.1. Incremento en las utilidades ante el incremento en las ventas. -- 9.2. Incremento en el costo por la inversión en las cuentas por cobrar. -- 9.3. Incremento en el costo por incobrables. -- 9.4. Síntesis del proceso de análisis de cartera. -- 10. Rentabilidad del activo. -- 10.1. Rentabilidad operacional del activo. -- 10.2. Rentabilidad neta del activo. -- 11. Comparativa competencia. -- 12. Productos a analizar. -- 13. Análisis de referencias. -- 14. Producción. -- 15. Conclusiones y [email protected]@[email protected]

Viral Infection in Adults with Severe Acute Respiratory Infection in Colombia.

To identify the viral aetiology in adult patients with severe acute respiratory infection (SARI) admitted to sentinel surveillance institutions in Bogotá in 2012.A cross-sectional study was conducted in which microarray molecular techniques for viral identification were used on nasopharyngeal samples of adult patients submitted to the surveillance system, and further descriptions of clinical features and relevant clinical outcomes, such as mortality, need for critical care, use of mechanical ventilation and hospital stay, were obtained.Respiratory infections requiring hospital admission in surveillance centres in Bogotá, Colombia.Ninety-one adult patients with acute respiratory infection (55% were female).Viral identification, intensive care unit admission, hospital stay, and mortality.Viral identification was achieved for 63 patients (69.2%). Comorbidity was frequently identified and mainly involved chronic pulmonary disease or pregnancy. Influenza, Bocavirus and Adenovirus were identified in 30.8%, 28.6% and 18.7% of the cases, respectively. Admission to the intensive care unit occurred in 42.9% of the cases, while mechanical ventilation was required for 36.3%. The average hospital stay was 9.9 days, and mortality was 15.4%. Antibiotics were empirically used in 90.1% of patients.The prevalence of viral aetiology of SARI in this study was high, with adverse clinical outcomes, intensive care requirements and high mortality

Characteristics of patients included in the study.

<p>Characteristics of patients included in the study.</p

Outcomes of included patients.

<p>Outcomes of included patients.</p

Flow diagram of subject identification, sample processing and categorisation.

<p>Four patients did not have molecular results (right arm).</p

Identified viruses.

<p>Identified viruses.</p

Comparative clinical characteristics of the patients, by group.

<p>Comparative clinical characteristics of the patients, by group.</p

Characteristics and long‐term outcomes of advanced pleural mesothelioma in Latin America (MeSO‐CLICaP)

Background Malignant pleural mesothelioma (MPM) is an aggressive tumor, associated with poor prognosis. There is a lack of information about the clinical and pathological features related with survival in the Latin American population. Methods The MeSO‐CLICaP registry identified 302 patients with advanced MPM diagnosed and treated between January 2008 and March 2016. The Cox model was applied to determine the variables associated with survival. A random forest tree model was built to predict the response to first‐line chemotherapy among Latin American patients. Results The median age was 61.1 years (SD 10.6 years), 191 (63.2%) were men, 65.9% were ever smokers, and 38.7% had previous exposure to asbestos. A total of 237 (78.5%) had epithelioid tumors, and 188 (62.3%) and 114 (37.7%) cases had stage III or IV MPM, respectively. A total of 49 patients (16.2%) underwent pleurectomy, 57 (18.9%) received radiotherapy, and 279 patients received first‐line platinum‐based chemotherapy. The overall response rate to first‐line chemotherapy was 40.4%, progression‐free survival to first‐line treatment was 5.7 months (95% CI 4.9–6.5), and 63 (20.8%) patients had pemetrexed maintenance. The median overall survival was 16.8 months (95% CI 13.0–20.5), and multivariate analysis found that stage (P = 0.013), and pleurodesis (P = 0.048), were independent prognostic factors for first‐line overall survival. The model to predict response to first‐line chemotherapy obtained a 0.98 area under the curve, a sensitivity of 93%, and a specificity of 95% for detecting responders and non‐responders. Conclusion This study identifies factors associated with clinical benefit from chemotherapy among advanced MPM Latin American patients, emphasizing the impact of histology and the clinical benefit of chemotherapy on outcomes