The Current Situation of Preschool Education Development in Ethnic Areas and Its Improvement Strategies: Take W County, S Province as an Example

With the increasing emphasis of the state on preschool education, pre-school education in ethnic minority areas has developed rapidly in terms of hardware conditions, teachers and curriculum construction. However, due to the constraints of geographical distribution and social and economic development level, the development of preschool education in ethnic areas still faces many difficulties and needs to be further improved. This study selected W County, S Province as the object, and used the interview method to investigate the development status of preschool education in this county, and put forward relevant development strategies based on this. The results show that in recent years, preschool education in W County has greatly improved in the construction of kindergartens, the number of teachers and the admission rate, but it still needs to be further strengthened in the layout of preschool resources, the construction of teachers, parents’ education concepts and the penetration of local culture

Development of supercritical processes for particle coating / encapsulation with polymers

This work presents the investigation of particle coating using supercritical fluid processes as novel coating approaches to coat particles from 20 nanometers to 500 microns with different polymers. Particle coating using different supercritical technologies of a modified rapid expansion of a supercritical solution (RESS) for particle coating and a supereritical antisolvent (SAS) process was described. In the modified RESS process for particle coating, experiments were performed using a pilot-scale supercritical apparatus, glass beads as host particles and two different polymers as coating materials. By adjusting temperature and pressure, the polymer nucleated and precipitated onto the surface of the host particles in a precipitation chamber due to the significantly lowered solubility of polymer in supercritical CO2. The glass beads were found coated with poly vinyl chloride-co-vinyl acetate (PVCVA) and hydroxypropyl cellulose (HPC) although the coating was not uniform and not continuously distributed over the surface of the particles. The main part of this work is the study of the SAS process for particle coating. The supercritical fluid worked as an antisolvent in the SAS process instead of a solvent in the RESS. The SAS process is based on the principle of SC CO2 induced phase separation in which the solute precipitates due to a high super-saturation produced by the mutual diffusion between organic solvent and SC CO2 when an organic liquid solution comes into contact with SC CO2. Systematic study of the effects of process conditions on the coating of particles in the SAS process was performed. The polymer weight fraction and polymer concentration played critical roles in the agglomeration of coated particles and the thickness of coating. Higher pressure facilitated the Tg depression, enhancing the agglomeration of coated particles. Operating temperature had no visible effect on the coating effect when the temperature was below Tg. The coating quality also was independent of spraying velocity. Surfactants had adverse effects on the coating quality. The application of SAS particle coating process in the design of drug delivery system was studied. A biopolymer of poly lactide-co-glycolide (PLGA 50/50) and hydrocortisone were selected as the coating material and the model drug, respectively. The hydrocortisone particles were successfully coated with PLGA. At higher polymer loading ratios, the coated drug particles showed sustained release behavior. Higher polymer loading ratio produced higher encapsulation efficiency

The Basic Experience of Seizing the Cultural Hegemony of the CPC in the Liberation War

The cultural hegemony is identified by the ideology of the ruling class, which is a theoretical model to get the political leadership through “mobile warfare” and “trench warfare”. In the Liberation War, according to the adjusted strategy, the Chinese Communist Party united with all those that can be united with to obtain people’s cultural and ideological identity. The CPC continued to strengthen its construction of the members and through theoretical study guiding the practice to increase the rallying power and combat capacity. It also through the combination of violent revolution and ideology identity, carried out the great practice of seizing the cultural hegemony, thus forming the base and valuable experience

Normalized solution to the nonlinear p-Laplacian equation with an L^2 constrain: mass supercritical case

In this paper, we study the existence of ground state solutions to the following p-Laplacian equation in some dimension $N\geq3$ with an $L^2$ constraint: \begin{equation*} \begin{cases} -\Delta_{p}u+{\vert u\vert}^{p-2}u=f(u)-\mu u \quad \text{ in } \mathbb{R}^N,\\ {\Vert u\Vert}^2_{L^2(\mathbb{R}^N)}=m,\\ u\in W^{1,p}(\mathbb{R}^N)\cap L^2(\mathbb{R}^N), \end{cases} \end{equation*} where $-\Delta_{p}u=div\left( {\vert\nabla u\vert}^{p-2}\nabla u \right)$, $2\leq p<N$, $f\in C(\mathbb{R},\mathbb{R})$, $m>0$, $\mu\in\mathbb{R}$ will appear as a Lagrange multiplier and the continuous nonlinearity $f$ satisfies mass supercritical conditions. We mainly study the behavior of ground state energy $E_m$ with $m>0$ changing within a certain range and aim at extending nonlinear scalar field equation when $p=2$ and reducing the constraint condition of nonlinearity $f$.Comment: arXiv admin note: text overlap with arXiv:2002.03973 by other author

Genetic liability between COVID-19 and heart failure: Evidence from a bidirectional mendelian randomization study

Background: Previous studies have observed inconsistent associations between coronavirus disease 2019 (COVID-19) and heart failure (HF), but these studies were prone to bias based on reverse causality and residual confounding factors. We aimed to investigate genetic liability between COVID-19 and heart failure using a bidirectional Mendelian randomization study. Methods: The causal relationship between COVID-19 (including COVID-19, hospitalized COVID-19 compared with the general population, and severe COVID-19) and HF are determined by using a bidirectional Mendelian randomization analysis. We drew on summary statistics from the largest HF genome-wide association study (GWAS) meta-analysis on individuals of European ancestry, which included 47,309 HF patients and 930,014 controls. The inverse variance weighted (IVW), an adaption of the Egger regression (MR-Egger), the weighted median, and weighted model were conducted for the Mendelian randomization analysis to estimate a causal effect. To confirm the stability, we performed a “leave-one-out” approach for the sensitivity analysis. Results: Genetically predicted severe COVID-19 was not significantly associated with the risk of HF [odds ratio (OR), 1.003; 95% confidence interval (CI), 0.969–1.037; p = 0.867]. The IVW demonstrated that there was no association between genetically hospitalized COVID-19 infection and HF risk [OR, 1.009; 95% CI, 0.939–1.085; p = 0.797]. There was no evidence to support the association between genetically determined COVID-19 and the risk of HF [OR, 1.066; 95% CI, 0.955–1.190; p = 0.253]. In addition, genetically predicted HF was also not causally associated with COVID-19 [OR, 1.162; 95% CI, 0.824–1.639; p = 0.393]. MR-Egger analysis indicated no evidence of directional pleiotropy. Conclusion: The current bidirectional Mendelian randomization analysis overcomes the limitations of observational studies. Our findings indicated that there is no causal association between COVID-19 and HF