Dissipation rate of turbulent kinetic energy in stably stratified sheared flows

Over the years, the problem of dissipation rate of turbulent kinetic energy (TKE) in stable stratification remained unclear because of the practical impossibility to directly measure the process of dissipation that takes place at the smallest scales of turbulent motion. Poor representation of dissipation causes intolerable uncertainties in turbulence-closure theory and thus in modelling stably stratified turbulent flows. We obtain a theoretical solution to this problem for the whole range of stratifications from neutral to limiting stable; and validate it via (i) direct numerical simulation (DNS) immediately detecting the dissipation rate and (ii) indirect estimates of dissipation rate retrieved via the TKE budget equation from atmospheric measurements of other components of the TKE budget. The proposed formulation of dissipation rate will be of use in any turbulence-closure models employing the TKE budget equation and in problems requiring precise knowledge of the high-frequency part of turbulence spectra in atmospheric chemistry, aerosol science, and microphysics of clouds.Peer reviewe

The June 2016 Optical and Gamma-Ray Outburst and Optical Micro-Variability of the Blazar 3C454.3

The quasar 3C454.3 underwent a uniquely-structured multi-frequency outburst in June 2016. The blazar was observed in the optical $R$ band by several ground-based telescopes in photometric and polarimetric modes, at $\gamma$-ray frequencies by the \emph{Fermi}\ Large Area Telescope, and at 43 GHz with the Very Long Baseline Array. The maximum flux density was observed on 2016 June 24 at both optical and $\gamma$-ray frequencies, reaching $S^\mathrm{max}_\mathrm{opt}=18.91\pm0.08$ mJy and $S_\gamma^\mathrm{max} =22.20\pm0.18\times10^{-6}$ ph cm$^{-2}$ s$^{-1}$, respectively. The June 2016 outburst possessed a precipitous decay at both $\gamma$-ray and optical frequencies, with the source decreasing in flux density by a factor of 4 over a 24-hour period in $R$ band. Intraday variability was observed throughout the outburst, with flux density changes between 1 and 5 mJy over the course of a night. The precipitous decay featured statistically significant quasi-periodic micro-variability oscillations with an amplitude of $\sim 2$-$3\%$ about the mean trend and a characteristic period of 36 minutes. The optical degree of polarization jumped from $\sim3\%$ to nearly 20\% during the outburst, while the position angle varied by \sim120\degr. A knot was ejected from the 43 GHz core on 2016 Feb 25, moving at an apparent speed $v_\mathrm{app}=20.3c\pm0.8c$. From the observed minimum timescale of variability $\tau_\mathrm{opt}^\mathrm{min}\approx2$ hr and derived Doppler factor $\delta=22.6$, we find a size of the emission region $r\lesssim2.6\times10^{15}$ cm. If the quasi-periodic micro-variability oscillations are caused by periodic variations of the Doppler factor of emission from a turbulent vortex, we derive a rotational speed of the vortex $\sim0.2c$.Comment: 19 pages, 13 figures, 3 tables, accepted to the Astrophysical Journal 2019 March

Emission-line Variability during a Nonthermal Outburst in the Gamma-Ray Bright Quasar 1156+295

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.We present multi-epoch optical spectra of the γ-ray bright blazar 1156+295 (4C +29.45, Ton 599) obtained with the 4.3 m Lowell Discovery Telescope. During a multiwavelength outburst in late 2017, when the γ-ray flux increased to 2.5 × 10−6 phot cm−2 s−1 and the quasar was first detected at energies ≥100 GeV, the flux of the Mg ii λ2798 emission line changed, as did that of the Fe emission complex at shorter wavelengths. These emission-line fluxes increased along with the highly polarized optical continuum flux, which is presumably synchrotron radiation from the relativistic jet, with a relative time delay of ≲2 weeks. This implies that the line-emitting clouds lie near the jet, which points almost directly toward the line of sight. The emission-line radiation from such clouds, which are located outside the canonical accretion-disk related broad-line region, may be a primary source of seed photons that are up-scattered to γ-ray energies by relativistic electrons in the jet. © 2022. The Author(s). Published by the American Astronomical Society.This research was supported in part by NASA Fermi guest investigator program grants 80NSSC19K1504 and 80NSSC20K1565. We thank A. Tchekhovskoy for discussion of possible origins of the variable line-emitting clouds. These results made use of the Lowell Discovery Telescope (LDT) at Lowell Observatory. Lowell Observatory is a private, non-profit institution dedicated to astrophysical research and public appreciation of astronomy, and operates the LDT in partnership with Boston University, the University of Maryland, the University of Toledo, Northern Arizona University and Yale University. This study was based in part on observations conducted using the 1.8 m Perkins Telescope Observatory (PTO) in Arizona, which is owned and operated by Boston University. I.A. acknowledges financial support from the Spanish "Ministerio de Ciencia e Innovación" (MCINN) through the "Center of Excellence Severo Ochoa" award for the Instituto de Astrofísica de Andalucía-CSIC (SEV-2017-0709). Acquisition and reduction of the MAPCAT data were supported in part by MICINN through grants AYA2016-80889-P and PID2019-107847RB-C44. The MAPCAT observations were carried out at the German-Spanish Calar Alto Observatory, which is jointly operated by Junta de Andalucía and Consejo Superior de Investigaciones Científicas. Data from the Steward Observatory spectropolarimetric monitoring project were used; this program was supported by Fermi Guest Investigator grants NNX08AW56G, NNX09AU10G, NNX12AO93G, and NNX15AU81G. C.C. acknowledges support from the European Research Council (ERC) under the European Union Horizon 2020 research and innovation program under the grant agreement No. 771282.Peer reviewe

MEANS FOR EDUCATING PROFESSIONAL INTERPRETERS AND TRANSLATORS

Целью статьи является анализ средств профессиональной подготовки переводчиков. Автор определяет предметную область рассматриваемого вопроса в контексте существующих традицийтрактовки терминов «средство обучения», «профессиональная подготовка», «профессиональная компетентность» и создает системную классификацию базовых средств в соответствии с релевантнымикритериями. Новизна исследования связана с комплексностью и органичной целостностью созданной системы, а так же с тем, что автор включает в свою классификацию (помимо традиционныхсредств) недавно появившиеся средства мультимедийного характера, внимание к которым в виду специфики современной парадигмы развития общества возрастает, однако исследований покачественному использованию этого ресурса недостаточно. Принимая во внимание тот факт, что любое средство обучения является лишь способом реализации педагогической задачи и результат егоиспользования зависит не только от потенциальных возможностей самого средства, но и от грамотности преподавателя, автор статьи в рамках предлагаемой классификации анализируетперспективность различных средств и способы улучшения их эффективности. Результаты анализа представляют интерес прежде всего для работников вузов, занимающихся подготовкой переводчиков всфере профессиональной коммуникации, однако рекомендации по использованию средств могут быть актуальны для преподавателей любых областей знания, если они интересуются инновационнымитехнологиями и повышением эффективности образовательного процесса.The purpose of the article is to analyze the means (techniques) which help to educate professional interpreters and translators. The author defines the subject area in the context of existing traditions of interpretation ofnecessary terms such as «educational means», «professional education», «professional competence», and creates a comprehensive classification of basic means in accordance with relevant criteria. The value of theresearch is in the organic integrity of the created system and in the techniques analyzed: the author includes in the classification not only traditional means, but also the means of multimedia character which appeared notso long ago and haven’t been studied properly in spite of the fact that their popularity is growing due to the peculiar features of the modern paradigm of social development. Taking into consideration the fact that anyeducational means is simply the way of achieving the teaching goal and the result of its usage depends not only on the inherent potential of different means but also on the literacy (knowledge and skills) of the teacher, theauthor analyses the techniques of application of these means which help to rationalize the learning process and to achieve a better educational result. The research is targeted at university lecturers dealing with educatingprofessional interpreters and translators, but it can also draw the attention of lecturers and teachers belonging to other knowledge spheres if they are interested in innovative technologies and effective educational process

Immunophenotype of Measurable Residual Blast Cells as an Additional Prognostic Factor in Adults with B-Cell Acute Lymphoblastic Leukemia

Measurable residual disease (MRD) is a well-known independent prognostic factor in acute leukemias, and multicolor flow cytometry (MFC) is widely used to detect MRD. MFC is able not only to enumerate MRD accurately but also to describe an antigen expression profile of residual blast cells. However, the relationship between MRD immunophenotype and patient survival probability has not yet been studied. We determined the prognostic impact of MRD immunophenotype in adults with B-cell acute lymphoblastic leukemia (B-ALL). In a multicenter study RALL-2016 (NCT03462095), 267 patients were enrolled from 2016 to 2022. MRD was assessed at the end of induction (day 70) in 94 patients with B-ALL by six- or 10-color flow cytometry in the bone marrow specimens. The 4 year relapse-free survival (RFS) was lower in MRD-positive B-ALL patients [37% vs. 78% (p p = 0.004), 0% vs. 51% (p p = 0.02), respectively]. The MRD immunophenotype is associated with RFS and could be an additional prognostic factor for B-ALL patients

Immunophenotype of Measurable Residual Blast Cells as an Additional Prognostic Factor in Adults with B-Cell Acute Lymphoblastic Leukemia

Measurable residual disease (MRD) is a well-known independent prognostic factor in acute leukemias, and multicolor flow cytometry (MFC) is widely used to detect MRD. MFC is able not only to enumerate MRD accurately but also to describe an antigen expression profile of residual blast cells. However, the relationship between MRD immunophenotype and patient survival probability has not yet been studied. We determined the prognostic impact of MRD immunophenotype in adults with B-cell acute lymphoblastic leukemia (B-ALL). In a multicenter study RALL-2016 (NCT03462095), 267 patients were enrolled from 2016 to 2022. MRD was assessed at the end of induction (day 70) in 94 patients with B-ALL by six- or 10-color flow cytometry in the bone marrow specimens. The 4 year relapse-free survival (RFS) was lower in MRD-positive B-ALL patients [37% vs. 78% (p < 0.0001)]. The absence of CD10, positive expression of CD38, and high expression of CD58 on MRD cells worsened the 4 year RFS [19% vs. 51% (p = 0.004), 0% vs. 51% (p < 0.0001), and 21% vs. 40% (p = 0.02), respectively]. The MRD immunophenotype is associated with RFS and could be an additional prognostic factor for B-ALL patients

Optical Outburst of the Blazar S4 0954+658 in Early 2015

We analyze the behavior of the BL Lac object S4 0954+658 during an unprecedented bright optical flare in early 2015. The optical flare was accompanied by a powerful γ -ray flare and the detection of very-high-energy γ -ray emission. We analyze total and polarized intensity images obtained with the VLBA at 43 GHz and discover a new bright polarized superluminal knot, which was ejected from the VLBI-core during the peak of the flare

Multiwavelength Monitoring of the Gamma-Bright Blazar Mkn 421

We present the results of photo-polarimetric monitoring observations of the blazar Markarian 421 carried out with different telescopes (the 0.4 m telescopes of St. Petersburg State University and the Pulkovo Observatory, the 0.7 m telescope of the Crimean Astrophysical Observatory) during 2008–2015. We analyse the optical data as well as gamma-ray ligh t curves obtained with the Fermi Large Area Telescope. The multiwavelength flux variations are discussed