Effect of the novel type coronavirus on the mental health of patients

BACKGROUND AND AIM: The novel Coronavirus disease (COVID-19) emerged in China in 2019 and significantly affected the entire world. The pandemic and the restrictions led to an increase in the frequency of mental health disorders (i.e., depression and anxiety) and insomnia. The aim of the study was to evaluate mental health disorders in patients who were hospitalized because of COVID-19. The patients were evaluated 6 months after hospital discharge. METHODS: A total of 114 patients who were hospitalized at Ufuk University Hospital with the diagnosis of COVID-19 were consented to participate in the posttreatment questionnaire about demographics and a Depression, Anxiety, and Stress Scale-21. The Pittsburgh Sleep Quality Index was also given to the patients to answer. RESULTS: In our study, anxiety symptoms were detected in 34 (29.8%) individuals, stress symptoms in 9 (7.9%) individuals, and depressive symptoms in 17 (14.9%). When gender, education level, age, and marital status were evaluated, there was no significant relationship observed between depression, anxiety and stress, and sleep disorders. Only those with a history of psychiatric illness had significantly higher levels of anxiety, stress, and depression (p=0.040, p=0.047, and p=0.009, respectively). Sleep quality was poor in 88 (77.2%) patients and good (normal) in 26 (22.8%) patients. CONCLUSIONS: The results show that the sleep quality of the patients deteriorated and the symptoms of stress and anxiety increased during the COVID-19 pandemic period. Patients with a previous history of psychiatric illness were more affected

Retrospective analysis of false positive ratio of our patients with lung cancer at positron emission tomography-CT screen

BACKGROUND: In lung cancer, staging is necessary to give the best treatment to the patient and to estimate the best prognosis. The aim of this study was to compare the pathology results of the lung masses and mediastinal lymph nodes and to evaluate the sensitivity and specificity values of positron emission tomography-computerized tomography (PET-CT) and to determine the maximal threshold of maximum standardized uptake volume (SUVmax)

GPR56 homozygous nonsense mutation p.R271*associated with phenotypic variability in bilateral frontoparietal polymicrogyria

Polymicrogyria is a disorder of neuronal migration characterized by excessive cortical folding and partially fused gyri separated by shallow sulci. Homozygous mutations in the GPR56 gene, which regulates migration of neural precursor cells, are associated with bilateral frontoparietal polymicrogyria (BFPP) syndrome including white matter changes, brainstem and cerebellar involvement. Herein, we describe three siblings of consanguineous parents with a homozygous germline mutation (p.R271*) located in the seventh exon of the GPR56 gene that was previously detected in only one Portuguese patient. Phenotypic/genotypic relationships were analysed according to the clinical characteristics in only index patient. While earlier reported patient was exhibiting seizures provoked by hot water, macrocephaly, cerebellar/brainstem hypoplasia and corpus callosum abnormalities, the index patient showed only hypoplasia of brainstem, focal onset bilateral tonic clonic seizure. Despite the phenotypic similarities in two patients, the potential causes of the variation in the expression of the p.R271* variant between the two affected families might be genetic or epigenetic factors beyond the GPR56 gene. Consequently, the present findings show that the same mutation in GPR56 gene can have different phenotypic effects. Therefore, additional functional studies are needed to detect the phenotypic spectrum of the p.R271* mutation in GPR56, and provide insight into the mechanism of normal cortical development and regional patterning of the cerebral cortex

Effects of growth hormone treatment on ghrelin, leptin and adiponectin levels in Turner syndrome

WOS: 00023963060064

Clinical Characteristics of 46,XX Males with Congenital Adrenal Hyperplasia.

OBJECTIVE: To retrospectively evaluate the follow-up data in patients with 46,XX congenital adrenal hyperplasia (CAH) who were raised male. METHODS: A national database was created. The data of patients were asked to be recorded in the data form. RESULTS: The median (range) age of diagnosis was three (0.1-18.3) years in 44 patients. Twenty nine cases were diagnosed after the age of two years. Most (95.4%) cases were stage 4-5 virilized. Hysterectomy and bilateral salpingoopherectomy, at a median age of 7.25 (2.4-25.3) years, was performed in 35 cases. Testicular prostheses were placed in 11 (25%) cases at a median age of 11.2 (2.8-17) years. The median final height was 149.2 (132.8-172) cms in 38 patients, including simple virilizing (n=18), salt-wasting (n=6), and 11-beta hydroxylase (n=12). Of the 16 patients above the age of eighteen, university education was completed in 25%. CONCLUSION: It was seen that most (65.9%) of the 46,XX CAH cases raised male were diagnosed after two years of age. In these cases, hysterectomy and bilateral salpingoopherectomy, genital corrective surgeries and testicular prosthesis operations were performed in a very wide age rage

Molecular analysis of PROP1, POU1F1, LHX3, and HESX1 in Turkish patients with combined pituitary hormone deficiency: a multicenter study

WOS: 000355230500022PubMed ID: 25500790To investigate the specific mutations in PROP1, POU1F1, LHX3, and HESX1 genes in patients with combined pituitary hormone deficiency (CPHD) in Turkey. Seventy-six patients with CPHD were included in this study. Based on clinical, hormonal, and neuro-radiological data, relevant transcription factor genes were evaluated by Sanger sequencing and multiplex ligation-dependent probe amplification. Total frequency of mutations was 30.9 % in patients with CPHD. Frequency was significantly higher in familial patients (p = 0.001). Three different types of mutations in PROP1 gene (complete gene deletion, c.301-302delAG, a novel mutation; IVS1+2T > G) were found in 12 unrelated patients (21.8 %). Mutations in PROP1 gene were markedly higher in familial than in sporadic cases (58.8 vs. 5.3 %, p < 0.001). Homozygous complete gene deletion was the most common mutation in PROP1 gene (8/12) and was identified in six familial patients. Four different homozygous mutations [p.Q4X, novel mutations; exons 1-2 deletion, p.V153F, p.I244S] were detected in POU1F1 gene. Central precocious puberty was firstly observed in a sporadic-male patient with homozygous POU1F1 (p.I244S) mutation. A homozygous mutation in HESX1 gene (p.R160H) was detected in one patient. This study is the first to investigate specific mutations in CPHD patients in Turkey. Complete deletion in PROP1 gene was the most common mutation encountered in patients with CPHD. We believe that the results of this study will contribute to the establishment of genetic screening strategies in Turkey, as well as to the studies on phenotype-genotype correlations and early diagnosis of CPHD patients.Scientific and Technological Research Institution of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [106S277-SBAG-3488]; Scientific Research Projects Coordination Unit of Istanbul UniversityIstanbul University [2871]This work was supported by Scientific and Technological Research Institution of Turkey (Project Number: 106S277-SBAG-3488) and Scientific Research Projects Coordination Unit of Istanbul University (Project Number: 2871). The authors would like to thank Professor Olcay Neyzi, MD, of the Istanbul Faculty of Medicine, Istanbul University, for helpful discussions and critical reading of the manuscript