Does Political Reservation Affect Voting Behavior? Empirical Evidence from India

Using microdata from the National Election Study of the 2004 parliamentary elections in India, we empirically examine the impact of political reservation for disadvantaged castes and tribes on voting behavior. We find that in a reserved constituency, where only members of the disadvantaged castes can stand for election, voters of the disadvantaged castes are encouraged to vote. On the other hand, the system of constituency reservation does not have any impact on the turnout of voters belonging to other groups, including relatively upper caste voters. These voters, however, tend to change political party to vote for in reserved constituencies. These findings imply that there is a general acceptance of political reservation in the Indian electoral system.Political Reservation, Voter Turnout, Castes, India

Model-Informed Vancomycin Dosing Optimization to Address Delayed Renal Maturation in Infants and Young Children with Critical Congenital Heart Disease

This is the peer reviewed version of the following article, Shimamoto Y., Fukushima K., Mizuno T., et al. Model-Informed Vancomycin Dosing Optimization to Address Delayed Renal Maturation in Infants and Young Children with Critical Congenital Heart Disease. Clinical Pharmacology and Therapeutics 115, 239 (2024), which has been published in final form at https://doi.org/10.1002/cpt.3095. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.Ensuring safe and effective drug therapy in infants and young children often requires accounting for growth and organ development; however, data on organ function maturation are scarce for special populations, such as infants with congenital diseases. Children with critical congenital heart disease (CCHD) often require multiple staged surgeries depending on their age and disease severity. Vancomycin (VCM) is used to treat postoperative infections; however, the standard pediatric dose (60–80 mg/kg/day) frequently results in overexposure in children with CCHD. In this study, we characterized the maturation of VCM clearance in pediatric patients with CCHD and determined the appropriate dosing regimen using population pharmacokinetic (PK) modeling and simulations. We analyzed 1,254 VCM serum concentrations from 152 postoperative patients (3 days–13 years old) for population PK analysis. The PK model was developed using a two-compartment model with allometrically scaled body weight, estimated glomerular filtration rate (eGFR), and postmenstrual age as covariates. The observed clearance in patients aged ≤ 1 year and 1–2 years was 33% and 40% lower compared with that of non-CCHD patients, respectively, indicating delayed renal maturation in patients with CCHD. Simulation analyses suggested VCM doses of 25 mg/kg/day (age ≤ 3 months, eGFR 40 mL/min/1.73 m2) and 35 mg/kg/day (3 months < age ≤ 3 years, eGFR 60 mL/min/1.73 m2). In conclusion, this study revealed delayed renal maturation in children with CCHD, could be due to cyanosis and low cardiac output. Model-informed simulations identified the lower VCM doses for children with CCHD compared with standard pediatric guidelines

Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean

Hepatitis B virus (HBV) infection can lead to serious liver diseases, including liver cirrhosis (LC) and hepatocellular carcinoma (HCC); however, about 85–90% of infected individuals become inactive carriers with sustained biochemical remission and very low risk of LC or HCC. To identify host genetic factors contributing to HBV clearance, we conducted genome-wide association studies (GWAS) and replication analysis using samples from HBV carriers and spontaneously HBV-resolved Japanese and Korean individuals. Association analysis in the Japanese and Korean data identified the HLA-DPA1 and HLA-DPB1 genes with Pmeta = 1.89×10−12 for rs3077 and Pmeta = 9.69×10−10 for rs9277542. We also found that the HLA-DPA1 and HLA-DPB1 genes were significantly associated with protective effects against chronic hepatitis B (CHB) in Japanese, Korean and other Asian populations, including Chinese and Thai individuals (Pmeta = 4.40×10−19 for rs3077 and Pmeta = 1.28×10−15 for rs9277542). These results suggest that the associations between the HLA-DP locus and the protective effects against persistent HBV infection and with clearance of HBV were replicated widely in East Asian populations; however, there are no reports of GWAS in Caucasian or African populations. Based on the GWAS in this study, there were no significant SNPs associated with HCC development. To clarify the pathogenesis of CHB and the mechanisms of HBV clearance, further studies are necessary, including functional analyses of the HLA-DP molecule

Does Political Reservation Affect Voting Behavior? Empirical Evidence from India

January 2013This paper empirically examines the impact of political reservation for disadvantaged groups on voting behavior. Using microdata from the National Election Study of the 2004 parliamentary elections in India, we find that in a reserved constituency, where only members of the disadvantaged castes can stand for election, voters of the disadvantaged castes are encouraged to vote. On the other hand, the system of constituency reservation does not have any impact on the turnout of voters belonging to other groups, including relatively upper caste voters. This finding suggests that political reservation does not crowd out the electoral participation of other groups. These voters, however, tend to vote for the right-wing political party in reserved constituencies. This implies a possibility that the political reservation might provoke a social cleavage along castes in Indian politics.39 p

Does Political Reservation Affect Voting Behavior? Empirical Evidence from India

Using microdata from the National Election Study of the 2004 parliamentary elections in India, we empirically examine the impact of political reservation for disadvantaged castes and tribes on voting behavior. We find that in a reserved constituency, where only members of the disadvantaged castes can stand for election, voters of the disadvantaged castes are encouraged to vote. On the other hand, the system of constituency reservation does not have any impact on the turnout of voters belonging to other groups, including relatively upper caste voters. These voters, however, tend to change political party to vote for in reserved constituencies. These findings imply that there is a general acceptance of political reservation in the Indian electoral system.基盤研究(S) = Grants-in-Aid for Scientific Research (S)37 p

Does Political Reservation Affect Voting Behavior? Empirical Evidence from India

41275This paper empirically examines the impact of political reservation for disadvantaged groups on voting behavior. Using microdata from the National Election Study of the 2004 parliamentary elections in India, we find that in a reserved constituency, where only members of the disadvantaged castes can stand for election, voters of the disadvantaged castes are encouraged to vote. On the other hand, the system of constituency reservation does not have any impact on the turnout of voters belonging to other groups, including relatively upper caste voters. This finding suggests that political reservation does not crowd out the electoral participation of other groups. These voters, however, tend to vote for the right-wing political party in reserved constituencies. This implies a possibility that the political reservation might provoke a social cleavage along castes in Indian politics

Does Political Reservation Affect Voting Behavior? Empirical Evidence from India

Using microdata from the National Election Study of the 2004 parliamentary elections in India, we empirically examine the impact of political reservation for disadvantaged castes and tribes on voting behavior. We find that in a reserved constituency, where only members of the disadvantaged castes can stand for election, voters of the disadvantaged castes are encouraged to vote. On the other hand, the system of constituency reservation does not have any impact on the turnout of voters belonging to other groups, including relatively upper caste voters. These voters, however, tend to change political party to vote for in reserved constituencies. These findings imply that there is a general acceptance of political reservation in the Indian electoral system.基盤研究(S) = Grants-in-Aid for Scientific Research (S