21 research outputs found
Triangular arbitrage as an interaction among foreign exchange rates
We first show that there are in fact triangular arbitrage opportunities in
the spot foreign exchange markets, analyzing the time dependence of the
yen-dollar rate, the dollar-euro rate and the yen-euro rate. Next, we propose a
model of foreign exchange rates with an interaction. The model includes effects
of triangular arbitrage transactions as an interaction among three rates. The
model explains the actual data of the multiple foreign exchange rates well.Comment: 19 pages, 21 eps files embedded. Physica A, to be publishe
Concurrent chemoradiotherapy with conventional fractionated radiotherapy and low-dose daily cisplatin plus weekly docetaxel for T2N0 glottic cancer
Triangular arbitrage as an interaction among foreign exchange rates
We first show that there are in fact triangular arbitrage opportunities in the spot foreign exchange markets, analyzing the time dependence of the yen-dollar rate, the dollar-euro rate and the yen-euro rate. Next, we propose a model of foreign exchange rates with an interaction. The model includes effects of triangular arbitrage transactions as an interaction among three rates. The model explains the actual data of the multiple foreign exchange rates well.
SNAP-25 Is a Target of Protein Kinase C Phosphorylation Critical to NMDA Receptor Trafficking
18 páginas, 8 figuras, 4 figuras suplementarias.Protein kinase C (PKC) enhances NMDA receptor (NMDAR)-mediated currents and promotes NMDAR delivery to the cell surface via SNARE-dependent exocytosis. Although the mechanisms of PKC potentiation are established, the molecular target of PKC is unclear. Here we show that synaptosomal-associated protein of 25 kDa (SNAP-25), a SNARE protein, is functionally relevant to PKC-dependent NMDAR insertion, and identify serine residue-187 as the molecular target of PKC phosphorylation. Constitutively active PKC delivered via the patch pipette potentiated NMDA (but not AMPA) whole-cell currents in hippocampal neurons. Expression of RNAi targeting SNAP-25 or mutant SNAP-25(S187A) and/or acute disruption of the SNARE complex by treatment with BoNT A, BoNT B or SNAP-25 C-terminal blocking peptide abolished NMDAR potentiation. A SNAP-25 peptide and function-blocking antibody suppressed PKC potentiation of NMDA EPSCs at mossy fiber-CA3 synapses. These findings identify SNAP-25 as the target of PKC phosphorylation critical to PKC-dependent incorporation of synaptic NMDARs and document a postsynaptic action of this major SNARE protein relevant to synaptic plasticity.This work was supported by National Institutes of Health Grants NS20752 (to R.S.Z.), NS45287 (to M.V.L.B.), and
BFU2006-007138 (to J.L.).Peer reviewe