抗精神病薬投与および母体免疫活性によるエピゲノム・レトロトランスポゾン動態の解析

学位の種別: 課程博士審査委員会委員 : （主査）東京大学教授 辻 省次, 東京大学教授 尾藤 晴彦, 東京大学教授 後藤 由季子, 東京大学准教授 田中 輝幸, 東京大学講師 武笠 晃丈University of Tokyo(東京大学

Environmental Study in Elementary Geography in the United Kingdom by Analysis of Geographical School’s Textbook

Environmental education in elementary school in Japan is defined as “Moral Education” by the national curriculum. However, environmental education is one of the most important contents in geographical education. This study aims to clarify the contents in elementary geography in the United Kingdom by analyzing the elementary geographical textbook, in order to develop the basic environmental geographical education. And also we want to know how to educate environmental study in elementary school and how to improve it, from the view point of ESD (“Education for Sustainable Development”). Analyzed the elementary geographical textbooks, we find that it is effective for environmental education in UK to use various activities. All geographical textbooks foster problem solving abilities by using geographical activities and rearing scientific thinking

Two Distinct Pathways Mediated by PA28 and hsp90 in Major Histocompatibility Complex Class I Antigen Processing

Major histocompatibility complex (MHC) class I ligands are mainly produced by the proteasome. Herein, we show that the processing of antigens is regulated by two distinct pathways, one requiring PA28 and the other hsp90. Both hsp90 and PA28 enhanced the antigen processing of ovalbumin (OVA). Geldanamycin, an inhibitor of hsp90, almost completely suppressed OVA antigen presentation in PA28α−/−/β−/− lipopolysaccharide blasts, but not in wild-type cells, indicating that hsp90 compensates for the loss of PA28 and is essential in the PA28-independent pathway. In contrast, treatment of cells with interferon (IFN)-γ, which induces PA28 expression, abrogated the requirement of hsp90, suggesting that IFN-γ enhances the PA28-dependent pathway, whereas it diminishes hsp90-dependent pathway. Importantly, IFN-γ did not induce MHC class I expressions in PA28-deficient cells, indicating a prominent role for PA28 in IFN-γ–stimulated peptide supply. Thus, these two pathways operate either redundantly or specifically, depending on antigen species and cell type

Amphiphilic γ-cyclodextrin–fullerene complexes with photodynamic activity

Amphiphilic γ-cyclodextrin–fullerene 2 : 1 complexes (CLFCH complexes) were prepared by high-speed vibration milling of lipophilic tail-grafted γ-cyclodextrin (γ-CD), hydrophilic tail-grafted γ-CD and fullerene C₆₀. The transamidation of γ-CD–fullerene complexes having two amino groups with lipophilic and hydrophilic activated esters also afforded amphiphilic CLFCH complexes. Self-assemblies consisting of amphiphilic CLFCH complexes efficiently generated singlet oxygen under photoirradiation. Under visible light irradiation conditions, CLFCH complexes bearing a vitamin E moiety as a lipophilic tail showed high photodynamic activity toward cancer cells

広島大学考古学研究室所蔵の西アジア青銅柄鉄剣をめぐって

いわゆる「鉄芯」入り青銅剣（バイメタル青銅剣）とされてきた広島大学考古学研究室所蔵資料についての再調査を行う。バイメタル青銅剣は、紀元前800～1200ごろ年にカスピ海南部の山岳地帯において出現する金属器で、鉄利用の初期の様相を明らかにするうえで重要である。西アジア北部地域における鉄製利器の祖型として、鉄製棒状部品を内蔵する青銅剣（「鉄芯」入り青銅剣）の存在が指摘され、編年・機能研究が行われてきた。しかし、当該資料はおそらく現代において改変された青銅柄鉄剣であったことが判明した。他機関所蔵品の知見も加味すると、研究対象の多くに同様の可能性があり、「鉄芯入り」青銅剣を前提に導かれたこれまでの知見や議論は根本的な見直しを迫られることになる。紀元前2000年紀の終わりにカスピ海周辺に出現する「鉄芯入り」青銅剣が実は青銅柄鉄剣であったわけであり、それ以前に鉄製利器の導入期といった、より原初的な初期鉄器の実態がある可能性が高くなる。今回の再調査はそうした研究の脆弱性を露呈し、西アジアにおける初期鉄器時代の議論を転換する結果となった

Analysis for the units of regional geography on UK’s geography textbook: The case study of “Geog 4th edition”

In Britain, the volume of “Regional Geography” was decreased in “the National Curriculum”. The aim of this paper is to cralify the contents of “Regional Geography” in Britain. We analyzed the geographical school textbook “Geog 4th edition” by Oxfor University Press. We find that “Geog” has only 2 or 3 case studies in each grade. The students don’t learn all of the world in geographical class. That is because it is important to learn the geographical skill

Millimeter-wave communication system using photonic-based remote antennas for configurable network in dense user environment

Photonic-based millimeter-wave communication systems combined with conventional wireless systems have been proposed for the application in dense user environments like a large football stadium. By utilizing a narrow beam antenna for millimeter-wave asymmetric links, effective communication channels can be obtained

Competency of Education for Interntional Understanding: By analyzing Dircke Geography: For Bilingual Classes in Germany

This paper aims to clarify the characteristics of learning units on Education for International Understanding (EIU) and their structure, appropriate geographical teaching materials on EIU, streategies for competence acquisition, and perspectives of ESD within learning units on EIU by analyzing two learning units “Globalisation” and “Global Disparities” in the geography textbook for bilingual lesson ”Diercke Geography: For Bilingual Classes”. The results of the analysis showed that 1)“Globalisation” focuses on the theories of globalisation and “Global Disparities” aims to learn not only theories but also regionl images; 2) Competency is repeatedly acquired through different learning activities ; 3) “Global Disparities” is designed from the viewpoint of “think globally, act locally”

Education for Disaster Prevention in England : Analysis of Secondary Geography Textbooks

The purpose of this study is to clarify the aims, contents and activities of education for disaster prevention on geographical education in England, by analysis of secondary textbooks. Thereby, we want to contribute the improvement of Japanese geographical education. As a result, we clarified the following: 1) when students study a natural disaster in UK, they learn a plurality of cases including domestic and foreign regions, 2) all textbooks contain activities that students can form attitudes and decide what to do for disaster prevention. On the basis of these results, we suggest improvements of education for disaster prevention. The first is to develop a clear understanding of a natural disaster with multi-area including Japan. The second is to place contents and activities for forming a value relevant to awareness of disaster prevention into Japanese geography textbook. The third is to set an activity to learn practical strategies for disaster prevention in the real world