Effect of Kinesio tape and Compression sleeves on delayed onset of muscle soreness: a single-blinded randomized controlled trial

Abstract Background Both Kinesio Tape (KT) and Compression Sleeves (CS) can relieve Delayed Onset Muscle Soreness (DOMS) to a certain extent, but there is no study report on the difference in the effectiveness of the KT and CS whether the effect is better when used at the same time. The purpose of this study was to compare the effects of KT and CS on the recovery of muscle soreness, isokinetic strength, and body fatigue after DOMS. Methods In this single-blinded randomized controlled trial, 32 participants aged 18 to 24 years were randomly divided into Control group (CG), Compression Sleeves group (CSG), Kinesio Tape group (KTG), Compression Sleeves and Kinesio Tape group (CSKTG), between October 2021 and January 2022. KTG uses Kinesio Tape, CSG wears Compression Sleeves, and CSKTG uses both Compression Sleeves and Kinesio Tape. Outcomes were performed at five-time points (baseline, 0 h, 24 h, 48 h, 72 h), Primary outcome was pain level Visual Analogue Scale (VAS), and Secondary outcomes were Interleukin 6, Peak Torque/Body Weight, Work Fatigue. Statistical analyses were performed using the repeated measures analysis of variance method. Setting: Laboratory. Results After the intervention, VAS reached the highest at 24 h after exercise-induced muscle soreness, while the KTG and CSG at each time point were less than CG, and the scores of CSKTG at 24 h and 48 h were less than those of KTG and CSG in the same period (P < 0.05). Interleukin 6, at 24 h, CSKTG is lower than KTG 0.71(95%CI: 0.43 to 1.86) and CG 1.68(95%CI: 0.06 to 3.29). Peak Torque/Body Weight, at 24 h, CG was lower than CSKTG 0.99(95%CI: 0.42 to 1.56), KTG 0.94(95%CI: 0.37 to 1.52), and CSG 0.72(95%CI: 0.14 to 1.29); at 72 h, CG was lower than CSKTG 0.65(95%CI: 0.13 to 1.17) and KTG 0.58(95%CI: 0.06 to 1.10). Work Fatigue, at 24 h, CG was lower than KTG 0.10(95%CI: 0.02 to 1.78) and CSKTG 0.01(95%CI: -0.07 to 0.09). At 48 h, CG was lower than KTG 0.10(95%CI: 0.13 to 1.17) and CSKTG 0.11(95%CI: 0.03 to 0.18). Conclusions Kinesio Tape can significantly reduce DOMS pain, and Kinesio Tape has a better recovery effect on Delayed Onset Muscle Soreness than Compression Sleeves. Kinesio Tape combined with Compression Sleeves is helpful to alleviate the Delayed Onset Muscle Soreness pain, speeding up the recovery of muscle strength, and shortening the recovery time after Delayed Onset Muscle Soreness. Trial registration Registration number: This study was also registered on 11/10/2021, at the Chinese Clinical Trial Registry (ChiCTR2100051973)

Transcriptomic analysis of gene expression in mice treated with troxerutin.

Troxerutin, a semi-synthetic derivative of the natural bioflavanoid rutin, has been reported to possess many beneficial effects in human bodies, such as vasoprotection, immune support, anti-inflammation and anti-aging. However, the effects of troxerutin on genome-wide transcription in blood cells are still unknown. In order to find out effects of troxerutin on gene transcription, a high-throughput RNA sequencing was employed to analysis differential gene expression in blood cells consisting of leucocytes, erythrocytes and platelets isolated from the mice received subcutaneous injection of troxerutin. Transcriptome analysis demonstrated that the expression of only fifteen genes was significantly changed by the treatment with troxerutin, among which 5 genes were up-regulated and 10 genes were down-regulated. Bioinformatic analysis of the fifteen differentially expressed genes was made by utilizing the Gene Ontology (GO), and the differential expression induced by troxerutin was further evaluated by real-time quantitative PCR (Q-PCR)

Biomechanical effects of different staging and attachment designs in maxillary molar distalization with clear aligner: a finite element study

Abstract Background In the present study, the effects of distalizations of one and two molars with different step distances and attachment designs have been analyzed. Methods A 3D finite element analysis model has been developed in order to determine the tendency of tooth displacement and stress distribution with clear aligner treatment. Results Under the condition of single-molar distalization, when the step distance was set to 0.25 mm, the total displacement was 0.086 mm for central incisors, 0.080 mm for lateral incisors, 0.084 mm for canines, 0.102 mm for the first premolar and 0.076 mm for the second premolar. The von Mises stress of roots and the principal stress of the periodontal ligament was slightly lower than in the control group when the step distance was set to 0.130 mm. Under the condition of two-molar distalization, when the step distance was set to 0.130 mm, the total displacements for central incisors, lateral incisors and canines as well as both the first and second maxillary molars were basically the same as with a distance of 0.250 mm for one-molar distalization. In addition, when the step distance was 0.130 mm with two-molar distalization, the rotation center of the first and second molar was closer to the apex of the root indicating that the smaller step distance led to more bodily movement during the two-molar distalization. However, displacement tendencies of the first molar and the second molar were basically the same whether horizontal or vertical rectangular attachments were added. Conclusions A step distance of moving two molars to 0.130 mm can achieve the same reaction force on the anterior teeth as moving one molar 0.250 mm without effects on horizontal or vertical rectangular attachments. Clinical relevance Our results provide a theoretical basis and guidance for simultaneously moving two molars backward in clinical practice using a clear aligner

Transcriptomic analysis of gene expression in mice treated with troxerutin

<div><p>Troxerutin, a semi-synthetic derivative of the natural bioflavanoid rutin, has been reported to possess many beneficial effects in human bodies, such as vasoprotection, immune support, anti-inflammation and anti-aging. However, the effects of troxerutin on genome-wide transcription in blood cells are still unknown. In order to find out effects of troxerutin on gene transcription, a high-throughput RNA sequencing was employed to analysis differential gene expression in blood cells consisting of leucocytes, erythrocytes and platelets isolated from the mice received subcutaneous injection of troxerutin. Transcriptome analysis demonstrated that the expression of only fifteen genes was significantly changed by the treatment with troxerutin, among which 5 genes were up-regulated and 10 genes were down-regulated. Bioinformatic analysis of the fifteen differentially expressed genes was made by utilizing the Gene Ontology (GO), and the differential expression induced by troxerutin was further evaluated by real-time quantitative PCR (Q-PCR).</p></div

Directed acyclic graph (DAG) for differentially expressed genes (DEGs) in the biological process (BP) ontology.

<p>Directed acyclic graph (DAG) for differentially expressed genes (DEGs) in the biological process (BP) ontology.</p

Gene Ontology (GO) classification of differentially expressed genes (DEGs).

<p>DEGs are classified into three major domains: biological process (BP), cellular component (CC) and molecular function (MF). The left y-axis indicates the percentage of a specific category of genes in a domain. The right y-axis indicates the number of genes in the category. (Con, control group; YR, experimental group).</p

Reads coverage mapping to the reference genome of Kunming (Swiss) mice.

<p>C1, C2 and C3 represent control groups that received injection of normal saline (NS), and YR1, YR2 and YR3 represent experimental groups that received subcutaneous injection of TX dissolved in NS at a dose of 130 mg/kg, twice daily. Blue, green and orange refer to intergenic, exon and intron region respectively.</p

An Innovative Signal Processing Scheme for Spaceborne Integrated GNSS Remote Sensors

The vigorous development of the global navigation satellite system (GNSS) has led to a boom in GNSS radio occultation (GNSS RO) and GNSS reflectometry (GNSS-R) techniques. Consequently, we have proposed an innovative signal processing scheme for spaceborne integrated GNSS remote sensors (SIGRS), combining a GNSS RO and a GNSS-R module. In the SIGRS, the GNSS-R module shares one precise orbit determination (POD) module with the GNSS RO module, and the GNSS-R module first achieves compatibility with GPS, BDS, and Galileo. Moreover, the programmable non-uniform delay resolution was introduced and first used by the SIGRS to generate the output DDM, which achieves a high delay resolution in the DDM central region around the specular point to improve the accuracy of basic observables but requires fewer delay bins than the conventional DDM with uniform delay resolution. The SIGRS has been successfully used to design the GNOS II onboard the Chinese FY-3E satellite, and the results of in-orbit operation validate the performance of the SIGRS, which means the SIGRS is an economically and technically efficient design and has become the first successful signal processing scheme for spaceborne integrated GNSS remote sensors around the world

Q-PCR primers.

<p>Q-PCR primers.</p