Slope Stability from a Hydrological Perspective: Taking Typical Soil Slope as an Example

In the traditional research of slope stability, it is difficult to continuously obtain the moisture content of soil in long time sequences. In combination with the precipitation, temperature, and vegetation cover data in the study area, the variable infiltration capacity hydrological model is used to estimate the daily variation of soil moisture content, which is used as a calculation condition for the analysis of slope stability. The results show that, from 1970 to 2010, the spatial-temporal distribution of soil moisture content in the Weihe River Basin showed an increasing trend. Moreover, the shear strength of soil decreased, but the range was stable at approximately 2%. The strength reduction method based on the M-C inscribed circle criterion (DP3) shows that the slope stability factor k had an increasing trend for over 40 y. The portion of the period with a k value higher than 1.2 is more than 85% of the entire period, that with a k value between 1 and 1.2 is approximately 9%, and that with a k value less than 1 is approximately 5.5%. The R/S analysis results show that the Hurst coefficients of the τ-t curve and the k-t curve are 0.5568 and 0.5888, respectively, and that the slope is in a state of no variation. Based on these factors, the present and future of the slope is in a stable state. This scheme is a method of studying slope stability based on hydrology, and it provides a modern alternative for soil shear strength calculation and geological hazard assessment

Enhancement of strength mechanical and corrosion resistance of 7055 alloy with minor Sc and Y addition

A new type of 7055-Y-Sc alloy with high strength and corrosion resistance was prepared. Eutectic Al _3 Y particles with sizes in the range of 500–600 nm were found in the as-cast structure of the 7055-Y-Sc alloys. The addition of Y significantly accelerated the precipitation of Al _3 Zr with L1 _2 structure in Al–Zr–Y alloy, and the number density of Al _3 (Zr, Y) precipitates was almost a grade higher than that of Al _3 Zr. In the process of aging at 120 ℃/12 h, the nano scale L1 _2 -type Al _3 (Sc _x Y _y ) phase nucleated uniformly within the Al matrix and nonuniformly on the dislocation. The grain size decreased from 100–200 um in 7055-Y-0Sc to 40–50 um in 7055-Y-0.25Sc, the percentage of Sc continued to increase, and the grain size remained unchanged or even increased, thereby decreasing the Vickers hardness of 7055-Y-Sc alloys from 196.4 HV to 187.9 HV. After aging, the hardness and tensile properties of 7055-Y-Sc alloy showed good performance. The effective Sc proportion of the 7055-Y-Sc alloy was 0.25%. Its tensile strength was 398.6 MPa. Its conductivity was 33.8% IACS. The current corrosion density was 6.7 × 10 ^−8 A cm ^−2 , its good strength, corrosion resistance and conductivity make the studied alloy to be a promising material

Exploring environmental nanoplastics research: networks and evolutionary trends

Analyzing scientific advances and networks in NPs research can provide valuable insights into the evolving trends, research gaps, and priorities for future research efforts, highlighting the importance of scientific research in pollution control and risk management of uncontrolled and unknown nanoplastics (NPs) that pose a potential global threat, and have raised concerns in the scientific community and media. A total of 2055 nanoplastics (NPs) studies published from 1995 onwards were retrieved from the Web of Science Core Collection database. Bibliometric methods were applied to assess evolving scientific advances and networks. The general term, “nanoplastics,” was first introduced in 1995 as “intelligent” materials. Before 2009, defined as the ambiguous stage, NPs were produced and applied in many different manufacturing areas and processes. The first research referring to nano-scale plastic particles/debris as potential hazardous contaminants appeared in 2010. Thereafter, the number of annual publications on NPs has increased rapidly, particularly from 2018 onwards. Results showed China published 822 scientific papers, overtaking the United States’ 229 papers, whereas European researches, i.e., the Netherlands, Portugal, German, and the United Kingdom, led in quality and citation with extensive international collaborations. Furthermore, we concluded three main research themes from keyword cluster analysis: environmental monitoring (identification, quantification, fresh-water, marine-environment); environmental behaviors (fate, adsorption, aggregation, transport); and toxicology (toxicity, exposure, ingestion, oxidative stress). Toxicology and environmental behaviors of NPs were the leading themes. An overview of the current understanding of NPs in the above three major themes provides perspectives to identify future research directions based on knowledge gaps, e.g., advancing analytical methods, and exploring the mobility and fate of NPs in different ecosystems. Scientific research on NPs is a key fundamental requirement for their pollution control and risk management. To bridge the gap between research and reality, future efforts are required to promote the dissemination of scientific research findings and encourage actions in engineering, policy, education, etc., to support a sustainable society. Graphical Abstract: [Figure not available: see fulltext.].</p

A Facile FeCl₃/I₂‑Catalyzed Aerobic Oxidative Coupling Reaction: Synthesis of Tetrasubstituted Imidazoles from Amidines and Chalcones

A facile and efficient route for the synthesis of tetrasubstituted imidazoles from amidines and chalcones via FeCl₃/I₂-catalyzed aerobic oxidative coupling has been developed. This new strategy is featured by high regioselectivity and yields, good functional group tolerance, and mild reaction conditions

Susceptibility Of Ph-Positive All To Tki Therapy Associated With Bcr-Abl Rearrangement Patterns: A Retrospective Analysis

<div><p><i>Background</i></p><p>Tyrosine kinase inhibitors (TKIs) have demonstrated success in the treatment of acute lymphoblastic leukemia (ALL) in patients that express BCR-ABL rearrangements (Philadelphia chromosome [Ph]). The current study aimed to assess the efficacy of TKIs and prognostic factors in the treatment of adults with Ph+-ALL.</p><p><i>Methods</i></p><p>In this multicenter retrospective study, the relationship between Ph+-ALL and treatment outcomes among Chinese patients receiving TKI-containing induction/consolidation chemotherapy was examined. A total of 86 Ph+-ALL patients were included and followed for 3.85 (0.43–9.30) years. Overall survival (OS) and event-free survival (EFS) were analyzed.</p><p><i>Results</i></p><p>A total of 86 Ph+-ALL patients (40 females and 46 males; median age: 34.0 years) were enrolled, including those with BCR/ABL transcripts 190 (n = 52), 210 (n = 25), and 230 (n = 2); BCR/ABL isoform determination was not available for 7 patients. Mortality was influenced by variable BCR/ABL transcripts and TKI administration, and BCR/ABL transcripts, hematopoietic stem cell transplantation (HSCT), and TKI administration were associated with the occurrence of events. The OS rate in the TKI administration group during steady state was significantly higher compared with those patients who did not receive TKI administration (<i>P</i> = 0.008), the EFS rate in the TKI administration group during steady state was significantly higher compared with those patients who did not receive TKIs (<i>P</i> = 0.012), and also higher than those with TKI salvage administration (<i>P</i> = 0.004). BCR/ABL transcripts 210 showed preferable OS and EFS compared with BCR/ABL transcripts 190 and 230 (<i>P</i><0.05 for each).</p><p><i>Conclusions</i></p><p>The susceptibility of Ph+-ALL to TKI associated with the patterns of BCR-ABL rearrangement is demonstrated for the first time, thus adding another risk-stratifying molecular prognostic tool for the management of patients with Ph+-ALL.</p></div

Prognosis for OS (A) and EFS (B) in Various BCR/ABL Transcripts Groups.

<p>The log-rank tests showed improved prognosis as demonstrated in the OS and EFS curves for those patients with BCR/ABL transcripts 210 compared to those with BCR/ABL transcripts 190 and 230 (<i>P</i> = 0.039 and 0.016 for OS curves, and 0.029 and 0.028 for EFS curves, respectively).</p

Prognosis for OS (A) and EFS (B) in Various TKI Administration Groups.

<p>The log-rank tests showed better prognosis in OS and EFS curves of those with TKI administration in steady stage compared to those without TKI administration (<i>P</i> = 0.008 and 0.012), and a significant difference was observed between the EFS curves of those with TKI administration in steady stage compared to salvage administration (<i>P</i> = 0.004).</p

Multivariate Analyses: Contributing Factors for Mortality and Event Status.

<p>*p<0.05 indicates a significant influence on the occurrence of event.</p><p>Multivariate Analyses: Contributing Factors for Mortality and Event Status.</p