6 research outputs found
Macrostructure and Microenvironment Biomimetic Hydrogel: Design, Properties, and Tissue Engineering Application
The field of tissue engineering and
regenerative medicine is rapidly
advancing, with numerous novel and intriguing biomimetic materials
being reported. Hydrogels, due to their unique structure and properties
closely resembling biological tissues, stand as prime candidates for
mimicking natural tissues in tissue engineering and regenerative medicine
applications. In recent years, drawing inspiration from the intricate
structures found in biological soft tissues, researchers have successfully
created a range of biomimetic hydrogels. These hydrogels have been
tailored for diverse applications in fields such as biomedicine, tissue
engineering, flexible electronic devices, and beyond. However, designing
and fabricating biomimetic synthetic materials with intricate structures,
dynamic microenvironment systems, and integrated functionalities remains
challenging. This article presents the latest research progress in
macroscopic structural biomimetic hydrogels, as well as microenvironment
biomimetic hydrogels, along with the most recent construction strategies,
key design principles, and optimization mechanisms. It summarizes
their potential applications in various domains such as tissue repair,
signal detection and sensing, drug delivery, and more. Lastly, the
challenges and future development directions in the preparation and
application of biomimetic hydrogels are outlined
Lamellar Hierarchical Porous Carbon Prepared from Coal Tar Pitch through a Lamellar Hard Template Combined with the Precarbonization and Activation Method for Supercapacitors
The lamellar porous carbon favors the diffusion and penetration
of electrolyte ions and presents a fantastic advantage as an energy
storage electrode material. In this work, the lamellar Mg5(OH)4(CO3)2·4H2O
template is synthesized via a simple precipitation method in the low-temperature
hydrothermal condition. Lamellar hierarchical porous carbon (LHPC)
is successfully synthesized through the Mg5(OH)4(CO3)2·4H2O hard template and
the KOH activation method using coal tar pitch (CTP) as the carbon
source. The effects of activation temperature and activator dosage
on the morphology, microstructure, and supercapacitor performance
are researched at length. LHPCs-1–700 displays a good lamellar
structure and an abundant mesoporous structure, so as to exhibit superior
capacitive performance compared with other carbon electrodes. The
specific capacitance for LHPCs-1–700 reaches 298 F g–1 at 1 A g–1 and still maintains 234 F g–1 at 50 A g–1 with a high capacitance retention
of 78.5% in the three-electrode system. The kinetic behavior of the
LHPCs-1–700 electrode was also analyzed according to the CV
data obtained at different scan rates, and it was found that the fast
kinetic capacitance contribution was up to 87% at 200 mV s–1. The assembled LHPCs-1–700 symmetric supercapacitor delivered
an energy density of 16.73 W h kg–1 with a power
density of 859.4 W kg–1 in 1 M Na2SO4 solution. Besides, the specific capacitance retention rate
could still reach 95.8% after 8000 cycles
Analysis of samples with complex matrix by comprehensive gas chromatography
Komprehenzivní plynová chromatografie (GC×GC) je technika vhodná pro separaci komplikovaných organických směsí a nabízí mnoho výhod oproti běžné plynové chromatografii. Umožňuje kompletní analýzu vzorku současně na dvou odlišných kolonách, mezi kterými je rozhraní nazvané modulátor. Byla provedena analýza dvou éterických levandulových olejů a extraktu z levandule pomocí plynového chromatografu s pulzním tlakovým modulátorem a dvojicí detektorů: plamenově ionizačním detektorem a hmotnostním spektrometrem. Pro efektivní separaci vybraných olejů byly nalezeny optimální podmínky. Vstupní tlak na kolonu byl 250 kPa, první a druhý tlak nastavený na modulátoru byl 155 kPa a 175 kPa. Byl zvolen pomalejší teplotní program s počáteční teplotou 70 řC a nárůstem teploty 2 řC/min. Jako vhodná se ukázala modulační perioda v délce 5 s a s pulzem trvajícím 300 ms. Analyty byly identifikovány podle jejich hmotnostních spekter z MS detektoru. Nejvíce zastoupenými látkami v levandulových olejích byly terpeny. Složení levandulových olejů se liší v závislosti na druhu levandule, podmínkách pěstovaní i způsobu přípravy oleje. Klíčová slova: komprehenzivní plynová chromatografie, pulzní tlakový modulátor, levandulový ole
Additional file 8: Figure S5. of Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma
PA28α overexpression in OSCC cell lines promotes cell proliferation in vitro. PA28α overexpression stable OSCC cell lines (CAL27 and HSC3 cell) were assessed for cell proliferation by EdU assay. CAL27 and HSC3 cell morphology was assessed by laser scanning confocal microscopy (200×). After 24 hours transfection, cells were stained with Edu (Apoll 643, red color) and DAPI. Data are reported as means ± SEM for three independent experiments. A, PA28α overexpression in CAL27 and HSC3 cells was illustrated by Western blotting. B&C, Edu assay. (PPT 241 kb
Additional file 6: Figure S3. of Overexpression of proteasomal activator PA28Îą serves as a prognostic factor in oral squamous cell carcinoma
The curves showed that the survival in the subtypes divided by T-stage (A), Smoking (B) and Chemotherapy (C) and Lymphatic metastasis (D) were well separated. *Pâ<â0.05, P Values were calculated by the log-rank test. (PPT 232 kb
Additional file 1: Table S1. of Overexpression of proteasomal activator PA28Îą serves as a prognostic factor in oral squamous cell carcinoma
Common characteristics of study population (n=98). (DOCX 16 kb