Antimicrobial Activity and Composition of Rindera lanata (LAM.) Bunge var. canescens (ADC) Kosn. Essential oil Obtained by Hydrodistillation and Microwave Assisted Distillation

YUCEL, TAYYIBE BEYZA/0000-0002-2632-8325WOS: 000403499200013The composition of essential oils of Rindera lanata (LAM). Bunge var. canescens (A.D.C) Kosn. obtained by hydro-distillation (HD) and microwave assisted distillation (MW) by GC, GC/MS. Thirty three and thirty nine compounds were identified in the oils representing 81.20% and 78.57% of the oils obtained by HD and MW respectively. Aldehydes were shown to be the main group of constituents of the MW 40.11% and 15.23%, respectively. However, the major group in the HD was found to be 25.35% alcohols and 23.78% hydrocarbons. 6-Methyl heptan-2-ol (15.97%) was the main compound of the HD. Furthermore, in the MW assisted essential oil, the major compound present was decane (10.50%). Terpenoid class compounds were found in essential oils and oxygenated monoterpenes were determined as major group (13.34% and 7.19%). Antimicrobial activity of the isolated essential oils of the plant was also investigated and they showed moderate antimicrobial activity against the tested microorganisms.Karadeniz Technical University Research Fund; State Planning Agency (DPT) of TurkeyTurkiye Cumhuriyeti Kalkinma BakanligiThis work was supported by grants from Karadeniz Technical University Research Fund and State Planning Agency (DPT) of Turkey

Antimicrobial Activity and Composition of Rindera lanata (LAM.) Bunge var. canescens (ADC) Kosn. Essential oil Obtained by Hydrodistillation and Microwave Assisted Distillation

YUCEL, TAYYIBE BEYZA/0000-0002-2632-8325WOS: 000403499200013The composition of essential oils of Rindera lanata (LAM). Bunge var. canescens (A.D.C) Kosn. obtained by hydro-distillation (HD) and microwave assisted distillation (MW) by GC, GC/MS. Thirty three and thirty nine compounds were identified in the oils representing 81.20% and 78.57% of the oils obtained by HD and MW respectively. Aldehydes were shown to be the main group of constituents of the MW 40.11% and 15.23%, respectively. However, the major group in the HD was found to be 25.35% alcohols and 23.78% hydrocarbons. 6-Methyl heptan-2-ol (15.97%) was the main compound of the HD. Furthermore, in the MW assisted essential oil, the major compound present was decane (10.50%). Terpenoid class compounds were found in essential oils and oxygenated monoterpenes were determined as major group (13.34% and 7.19%). Antimicrobial activity of the isolated essential oils of the plant was also investigated and they showed moderate antimicrobial activity against the tested microorganisms.Karadeniz Technical University Research Fund; State Planning Agency (DPT) of TurkeyTurkiye Cumhuriyeti Kalkinma BakanligiThis work was supported by grants from Karadeniz Technical University Research Fund and State Planning Agency (DPT) of Turkey

Biological evaluation and synthesis of new pyrimidine-2(1H)-ol/-thiol derivatives derived from chalcones using the solid phase microwave method

Alpay Karaoglu, Sengul/0000-0003-1047-8350; YUCEL, TAYYIBE BEYZA/0000-0002-2632-8325WOS: 000431245300026Twenty-five new hydroxy- and methoxy-substituted 4,6-diarylpyrimidin-2(1H)-ol (20-34) and 4,6-diarylpyrimidine-2(1H)-thiol derivatives (35-44) were synthesized from the reaction of the corresponding 1,3-diaryl-2-propene-1-one compounds (1-19) with urea or thiourea using the solid-phase microwave method. All the new synthetic compounds (20-44) were evaluated with regard to their \g=a\-glucosidase activity. However, only compounds 22-25, 27, 31, 34, 35, 37, and 40 exhibited a greater inhibitory effect than standard acarbose. The IC50 values of the active compounds ranged between 2.36 and 13.34 mu M. The 25 new compounds were also screened for their in vitro pancreatic lipase activity and compounds 20-27 and 35-39 were found to be active. Of these compounds 26, 27, and 39 exhibited the best antilipase activities at concentrations of 0.40 +/- 0.06, 0.26 +/- 0.07, and 0.29 +/- 0.026 mu M. All the new compounds (20-44) were evaluated for their in vitro antimicrobial activity for nine test microorganisms. Compounds 20-24 and 35-39 were determined to possess a significant broad spectrum against the gram-positive bacteria Escherichia faecalis, Staphylococcus aureus, and Bacillus cereus among the tested bacterial agents. Compounds 20-24 and 35-39 exhibit the best activity against Mycobacterium smegmatis, with minimum inhibitory concentrations of 62.5-500 mu g/mL, indicating their potential use as antituberculous agents.Karadeniz Technical University Research Fund, Turkey [KTU-BAP-02 FHD5395]This study was supported by grants from Karadeniz Technical University Research Fund (KTU-BAP-02 FHD5395), Turkey