Backstepping controller design for a class of stochastic nonlinear systems with Markovian switching

A more general class of stochastic nonlinear systems with irreducible homogenous Markovian switching are considered in this paper. As preliminaries, the stability criteria and the existence theorem of strong solutions are first presented by using the inequality of mathematic expectation of a Lyapunov function. The state-feedback controller is designed by regarding Markovian switching as constant such that the closed-loop system has a unique solution, and the equilibrium is asymptotically stable in probability in the large. The output-feedback controller is designed based on a quadratic-plus-quartic-form Lyapunov function such that the closed-loop system has a unique solution with the equilibrium being asymptotically stable in probability in the large in the unbiased case and has a unique bounded-in-probability solution in the biased case

Electrochemical codeposition of nickel oxide and polyaniline

Nickel oxide (NiOx) and polyaniline (PAni) were electrocodeposited from NiSO4 and aniline through cyclic voltammetric scans to afford PAni–NiOx composite film at controlled pH environment. The electrochemical activities of the film were investigated by cyclic voltammetry in 0.1 M NaOH and 0.1 M H2SO4, respectively. Typical redox couples of PAni in 0.1 M H2SO4 appeared at approximately 0.2 and 0.4 V vs. saturated calomel electrode (SCE); Ni(II)/Ni(III) redox couple was observed at approximately 0.4 V vs. SCE in 0.1 M NaOH. The morphologies and elemental components of the films were inspected by scanning electron microscopy and energy dispersive X-ray diffraction. The stability of nickel oxide in the films was found to be enhanced against acidic environments. Electrochemical catalytic behavior of NiOx within the composite film was conserved and demonstrated by catalytic oxidation of methanol and ethanol

Steady Bell state generation via magnon-photon coupling

We show that parity-time ($\mathcal{PT}$) symmetry can be spontaneously broken in the recently reported energy level attraction of magnons and cavity photons. In the $\mathcal{PT}$-broken phase, magnon and photon form a high-fidelity Bell state with maximum entanglement. This entanglement is steady and robust against the perturbation of environment, in contrast to the general wisdom that expects instability of the hybridized state when the symmetry is broken. This anomaly is further understood by the compete of non-Hermitian evolution and particle number conservation of the hybridized system. As a comparison, neither $\mathcal{PT}$-symmetry broken nor steady magnon-photon entanglement is observed inside the normal level repulsion case. Our results may open a novel window to utilize magnon-photon entanglement as a resource for quantum technologies.Comment: 5 pages, 4 figure

Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling.

Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in the apoptotic process during cardiac ischaemia/reperfusion (I/R) injury. This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced cardiac apoptosis in vivo and in vitro via regulating HIF-1α signalling pathway. Rat myocardial I/R was induced by occluding the left anterior descending artery for 30 minutes followed by 6-hours reperfusion, and cardiomyocyte hypoxia/reoxygenation (H/R) was induced by oxygen-glucose deprivation for 6 hours followed by 3-hours reoxygenation. Dexmedetomidine administration at the beginning of reperfusion or reoxygenation attenuated I/R-induced myocardial injury or H/R-induced cell death, alleviated mitochondrial dysfunction, reduced the number of apoptotic cardiomyocytes, inhibited the activation of HIF-1α and modulated the expressions of apoptosis-related proteins including BCL-2, BAX, BNIP3, cleaved caspase-3 and cleaved PARP. Conversely, the HIF-1α prolyl hydroxylase-2 inhibitor IOX2 partly blocked DEX-mediated cardioprotection both in vivo and in vitro. Mechanistically, DEX down-regulated HIF-1α expression at the post-transcriptional level and inhibited the transcriptional activation of the target gene BNIP3. Post-treatment with DEX protects against cardiac I/R injury in vivo and H/R injury in vitro. These effects are, at least in part, mediated via the inhibition of cell apoptosis by targeting HIF-1α signalling

Synthesis of electrochemically-reduced graphene oxide film with controllable size and thickness and its use in supercapacitor

An electrochemical synthesis method of reducing graphene oxide (GO) under constant potential is reported. Electrochemical technique offers control over reaction parameters such as the applied voltage, electrical current and reduction time; whereas the desired size and thickness of the film can be pre-determined by controlling the amount of precur- sor GO deposited on the electrode with defined shape and surface area. This synthesis technique produces high quality electrochemically reduced GO (ERGO) film with control- lable size and thickness. Electrochemical symmetrical supercapacitors based on ERGO films achieved a specific capacitance of 128 F/g with an energy density of 17.8 Wh/kg operating within a potential window of 1.0 V in 1.0 M NaNO3. The supercapacitor was shown to be stable, retaining ca. 86% of the original specific capacitance after 3500 charge–discharge cycles. The results indicate that this simple synthesis technique for providing graphene-like materials has great potential in various applications such as energy storage

miRNA-124 in Immune System and Immune Disorders

In recent years, miR-124 has emerged as a critical modulator of immunity and inflammation. Here, we summarize studies on the function and mechanism of miR-124 in the immune system and immunity-related diseases. They indicated that miR-124 exerts a crucial role in the development of immune system, regulation of immune responses, and inflammatory disorders. It is evident that miR-124 may serve as an informative diagnostic biomarker and therapeutic target in the future

GPCR-like signaling mediated by smoothened contributes to acquired chemoresistance through activating Gli

BACKGROUND: Smoothened (Smo), which possesses a structural similarity with classic G-protein coupled receptors (GPCR), is the most important molecular target in Hedgehog (Hh) signaling system for developing anticancer drugs; however, whether Smo may transmit GPCR-like signaling to activate the canonical transcriptional factor Gli of Hh signaling system and consequently to be involved in the Gli-dependent biological events remains controversial. RESULTS: In this study, using the acquired chemoresistant cancer cell lines and their respective parental cells, we found that Smo may activate Gli through Gαi, Gβγ-JNK signaling axis, thereby promoting the Gli-dependent acquired chemoresistance. These observations were further complementarily strengthened by data obtained from chemosensitive cancer cells with artificially elevated Hh pathway activity. CONCLUSIONS: Hence, our data demonstrate that GPCR-like signaling mediated by Smo contributes to the acquired chemoresistance through activating the canonical Hh transcriptional factor Gli; therefore improving our knowledge of the nature of the signal transduction of Smo and the molecular mechanisms responsible for the acquired chemoresistance maintained by Hh pathway. Moreover, our data that JNK after activated by Smo-Gβγ signaling axis may stimulate the Gli activity and consequently promotes acquired chemoresistance expose a promising and potential target for developing anti-cancer drugs aimed at Hh pathway and for combating the acquired resistance raised by using of anti-cancer drugs targeting Smo

Anisotropic Convolutional Networks for 3D Semantic Scene Completion

As a voxel-wise labeling task, semantic scene completion (SSC) tries to simultaneously infer the occupancy and semantic labels for a scene from a single depth and/or RGB image. The key challenge for SSC is how to effectively take advantage of the 3D context to model various objects or stuffs with severe variations in shapes, layouts and visibility. To handle such variations, we propose a novel module called anisotropic convolution, which properties with flexibility and power impossible for the competing methods such as standard 3D convolution and some of its variations. In contrast to the standard 3D convolution that is limited to a fixed 3D receptive field, our module is capable of modeling the dimensional anisotropy voxel-wisely. The basic idea is to enable anisotropic 3D receptive field by decomposing a 3D convolution into three consecutive 1D convolutions, and the kernel size for each such 1D convolution is adaptively determined on the fly. By stacking multiple such anisotropic convolution modules, the voxel-wise modeling capability can be further enhanced while maintaining a controllable amount of model parameters. Extensive experiments on two SSC benchmarks, NYU-Depth-v2 and NYUCAD, show the superior performance of the proposed method. Our code is available at https://waterljwant.github.io/SSC

Clinical and pathological analysis of 504 cases of elderly ocular tumors

AIM:To analyze the composition, distribution and characteristics of the elderly primary ocular tumors. <p>METHODS: This was a retrospective study and all 504 cases with primary ocular tumors aged 60 years or older were collected in Shanxi Eye Hospital, during the year 2000-2012. The onset age, location and pathological pattern were analyzed.<p>RESULTS: There were 346 cases of benign ocular tumors(68.7%), and 158 cases of malignancy(31.3%).Papillomas was the most common type of the benign with 83 cases(16.5%), followed by a variety of inflammatory cysts and lesions with 69 cases(13.7%)and 64 cases(12.7%)respectively. Among malignant tumors cases, eyelid basal cell carcinoma originated from epithelial was the most common with 72 cases(14.3%), followed by skin appendages sources malignant tumors with 39 cases(7.7%). Concerning the location of ocular tumors, there were 282 cases of eyelid tumor(56.0%)occupied the first position followed by conjunctival tumor with 157 cases(31.2%). <p>CONCLUSION: The prevalence and type of primary ocular tumor in elderly people are significant differences from the general population and children's, and the proportion of malignant tumors tended to increase along with the increase of age