1,303 research outputs found
Building quantum neural networks based on swap test
Artificial neural network, consisting of many neurons in different layers, is
an important method to simulate humain brain. Usually, one neuron has two
operations: one is linear, the other is nonlinear. The linear operation is
inner product and the nonlinear operation is represented by an activation
function. In this work, we introduce a kind of quantum neuron whose inputs and
outputs are quantum states. The inner product and activation operator of the
quantum neurons can be realized by quantum circuits. Based on the quantum
neuron, we propose a model of quantum neural network in which the weights
between neurons are all quantum states. We also construct a quantum circuit to
realize this quantum neural network model. A learning algorithm is proposed
meanwhile. We show the validity of learning algorithm theoretically and
demonstrate the potential of the quantum neural network numerically.Comment: 10 pages, 13 figure
Interaction of Proliferation Cell Nuclear Antigen (PCNA) with c-Abl in Cell Proliferation and Response to DNA Damages in Breast Cancer
Cell proliferation in primary and metastatic tumors is a fundamental characteristic of advanced breast cancer. Further understanding of the mechanism underlying enhanced cell growth will be important in identifying novel prognostic markers and therapeutic targets. Here we demonstrated that tyrosine phosphorylation of the proliferating cell nuclear antigen (PCNA) is a critical event in growth regulation of breast cancer cells. We found that phosphorylation of PCNA at tyrosine 211 (Y211) enhanced its association with the non-receptor tyrosine kinase c-Abl. We further demonstrated that c-Abl facilitates chromatin association of PCNA and is required for nuclear foci formation of PCNA in cells stressed by DNA damage as well as in unperturbed cells. Targeting Y211 phosphorylation of PCNA with a cell-permeable peptide inhibited the phosphorylation and reduced the PCNA-Abl interaction. These results show that PCNA signal transduction has an important impact on the growth regulation of breast cancer cells
6,8-Dihydroxy-3-methylisocoumarin
The title compound, C10H8O4, was isolated from the fermentation culture of the endophytic fungus Cephalosporium sp. In the crystal structure, molecules are connected into a one-dimensional chain along [101] by intermolecular O—H⋯O hydrogen bonds involving the hydroxyl and carbonyl functionalities. The chains are linked by non-classical C—H⋯O interactions, forming extended two-dimensional layers approximately parallel to (11)
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