Association of sleep duration and sleep quality with the risk of metabolic syndrome in adults: a systematic review and meta-analysis

Introduction: The association between sleep duration and metabolic syndrome (MetS) remains controversial, and few have considered the effects of sleep quality. We performed a meta-analysis to clarify the relationship of sleep duration and sleep quality with the risk of MetS. Material and methods: We conducted a systematic and comprehensive literature search of electronic databases from inception to 17 February 2022. The effect sizes of covariates from each study were pooled using a random or fixed model, and a restricted cubic spline random-effects meta-analysis was performed to examine the dose-response relationship between sleep duration and MetS. Results: A total of 62 studies were included in this meta-analysis. Compared to normal sleep duration, short sleep duration [odds ratio (OR) = 1.14, 95% confidence interval (CI): 1.10–1.19] and long sleep duration (OR = 1.15, 95% CI: 1.09–1.23) were associated with an increased risk of MetS. The restricted cubic spline analysis indicated that sleep durations of 8.5 h (OR = 0.95, 95% CI: 0.92–0.97) and 11 h (OR = 1.58, 95% CI: 1.31–1.91) were significantly associated with the risk of MetS. The pooled results showed that poor sleep quality (OR = 1.46, 95% CI: 1.03–2.06) and sleep complaints had significant positive associations with MetS. Conclusion: Our results demonstrated that short sleep duration increased the risk of developing MetS. Long sleep duration was also associated with MetS, especially for 11 h. 8.5 h can be considered the recommended sleep duration for MetS. Poor sleep quality and sleep complaints were also associated with MetS

Increased CD45RA+FoxP3low Regulatory T Cells with Impaired Suppressive Function in Patients with Systemic Lupus Erythematosus

BACKGROUND: The role of naturally occurring regulatory T cells (Treg) in the control of the development of systemic lupus erythematosus (SLE) has not been well defined. Therefore, we dissect the phenotypically heterogeneous CD4(+)FoxP3(+) T cells into subpopulations during the dynamic SLE development. METHODLOGY/PRINCIPAL FINDINGS: To evaluate the proliferative and suppressive capacities of different CD4(+) T cell subgroups between active SLE patients and healthy donors, we employed CD45RA and CD25 as surface markers and carboxyfluorescein diacetatesuccinimidyl ester (CFSE) dilution assay. In addition, multiplex cytokines expression in active SLE patients was assessed using Luminex assay. Here, we showed a significant increase in the frequency of CD45RA(+)FoxP3(low) naive Treg cells (nTreg cells) and CD45RA(-)FoxP3(low) (non-Treg) cells in patients with active SLE. In active SLE patients, the increased proportions of CD45RA(+)FoxP3(low) nTreg cells were positively correlated with the disease based on SLE disease activity index (SLEDAI) and the status of serum anti-dsDNA antibodies. We found that the surface marker combination of CD25(+)CD45RA(+) can be used to defined CD45RA(+)FoxP3(low) nTreg cells for functional assays, wherein nTreg cells from active SLE patients demonstrated defective suppression function. A significant correlation was observed between inflammatory cytokines, such as IL-6, IL-12 and TNFα, and the frequency of nTreg cells. Furthermore, the CD45RA(+)FoxP3(low) nTreg cell subset increased when cultured with SLE serum compared to healthy donor serum, suggesting that the elevated inflammatory cytokines of SLE serum may promote nTreg cell proliferation/expansion. CONCLUSIONS/SIGNIFICANCE: Our results indicate that impaired numbers of functional CD45RA(+)FoxP3(low) naive Treg cell and CD45RA(-)FoxP3(low) non-suppressive T cell subsets in inflammatory conditions may contribute to SLE development. Therefore, analysis of subsets of FoxP3(+) T cells, using a combination of FoxP3, CD25 and CD45RA, rather than whole FoxP3(+) T cells, will help us to better understand the pathogenesis of SLE and may lead to the development of new therapeutic strategies

An Improved Analytical Model for Crosstalk of SiC MOSFET in a Bridge-Arm Configuration

SiC MOSFETs have an excellent characteristic of high switching speed, which can improve the efficiency and power density of converters significantly. However, the fast switching processes of SiC MOSFETs cause serious crosstalk problems in bridge-arm configurations, which restricts the devices’ performances. This paper presents a detailed and accurate improved crosstalk analytical model, which takes into account the nonlinear capacitances, the parasitic inductances, the reverse recovery characteristics of the anti-parallel diodes, and the nonlinear voltage switching and damping oscillation process. The novelty of the proposed model lies in the fact that under the condition of comprehensively considering all these non-ideal factors of the bridge-arm, the effects of multi-parasitic elements and multi-variables coupling to the crosstalk are hierarchically divided. The parasitic elements and their correlations are described in detail and the direct and indirect variables’ impacts are clearly traced. Thus, according to the different variables switching stages, the influence processes of these parasitic elements and variables can be integrated and a complete equivalent analytical model of the crosstalk process can be derived. The simulation and experiment platforms are established and a series of experimental verifications and comparisons prove that the model can replicate experimental measurements of crosstalk with good accuracy and detail

Development of sedimentary geology of petroliferous basins in China

This paper gives a contrastive analysis of the main progress made in petroliferous basins sedimentary geology domestically and internationally, and discusses the main problems and their solutions in the development of petroliferous basins sedimentology in China, New developments include coarse-grained depositional sysytem, shallow-water deltic depositional system, beach bar depositional system, deep-water gravity flows, fine-grained depositional system, carbonate reefs, mixosedimentite, microbialite, seismic sedimentology and sedimentary physical simulation. It also reveals the developing gap of Chinese sedimentology in the areas of microbialite and sedimentary simulation, etc. and analyzes the sedimentary features and paleogeography pattern of prototype basins, multi-scale paleogeographic recovery during major tectonic movements, the different explanation of new sedimentology theories in the deep-buried sandbodies development. The paper details the difficulties when it comes to the typical depositional systems combination and the setup of sedimentary models in China. Therefore, the developing tendency is described of sedimentology theories like source to sink, sedimentary dynamics as well as regional sedimentology in China, seismic sedimentology, and studying methods and technologies in sedimentary simulation. Key words: development, shallow-water delta, gravity flow, beach-bar, mixosedimentite, microbialite, seismic sedimentology, sedimentology, Chin

Alkaline diagenesis and its effects on reservoir porosity: A case study of Upper Triassic Chang 7 Member tight sandstone in Ordos Basin, NW China

Petrologic features, diagenetic processes and origins of different pore types of Upper Triassic Chang 7 (7th member of Yanchang Formation) tight sandstones in the Ordos Basin were analyzed based on cast thin sections, scanning electron microscope (SEM), and X-ray diffraction analysis (XRD). The diagenetic processes caused by alkaline pore fluid and associated pores were studied in detail and the relationship between porosity evolution and hydrocarbon accumulation was analyzed. The Chang 7 tight sandstone commonly experienced alkaline environment and associated diagenesis, including quartz dissolution or replaced by mica, clay and carbonate minerals, carbonate cementation, abundant authigenic illite and chlorite with minor kaolinte and smectite, and albitization. Several types of associated pores were formed in the alkaline environment, including quartz dissolution pore, intercrystal pore of clay minerals, interlamination pore of hydrated mica and pores associated with albitization. The alkaline diagenesis mainly occurred in two periods during the burial process: B stage of early diagenesis and A2 stage of mesogenetic diagenesis. The abundant intercrystal micropores of clay minerals, which mainly occurred during the B stage of early diagenesis, seriously reduced the permeability of sandstone. As a result, the acid dissolution in the later stage was not intense enough due to the low permeability, so it is inferred that the sandstone had already been compacted very tight before the major hydrocarbon charging. Key words: Ordos Basin, tight oil reservoir, alkaline diagenetic environment, diagenesis, pore typ

Phylogeographic analysis of genus Herichthys (Perciformes: Cichlidae), with descriptions of Nosferatu new genus and H. tepehua n. sp.

We access the evolutionary history of the genus Herichthys based on a phylogenetic reconstruction using a mitochondrial fragment of gene Cox1. We evaluate its morphological variation, its correspondence with molecular differentiation and suggest a biogeographical scenario based on a molecularclock and demographic history. Furthermore, we describe Nosferatu new genus, composed of Nosferatupame (assigned as type species),N. molango,N. pratinus, N. bartoni, N. labridens, N. pantostictus, and N. steindachneri. Genus is characterized by a transition to prolongation in the size of the symphysial pair of teeth relative to that of the other teeth in the outer row of the upper jaw; breeding pigmentation that consists of darkening of ventral area extending over nostrils, opercular series, or pectoral fins; depressed dorsal fin rarely expands beyond anterior third of caudal fin; and an elongated, elastic, smooth caecum adhered to a saccular stomach. We also describe Herichthys tepehua n. sp. found in the Pantepec, Cazones, Tenixtepec, Tecolutla, and Solteros rivers, in Veracruz, Mexico. Moreover, we provide re-descriptions for some of the species in Herichthys and propose a biogeographic hypothesis for both genera, based on available information on the geological and climate history of the area of study, associated to dating retrieved in our phylogenetic analysis.We also thank the funding support derived from the projects CGL2006-1235-BOS and CGL2010-15231-BOS.Peer Reviewe