System-Level Natural Language Feedback

Natural language (NL) feedback contains rich information about the user experience. Existing studies focus on an instance-level approach, where feedback is used to refine specific examples, disregarding its system-wide application. This paper proposes a general framework for unlocking the system-level use of NL feedback. We show how to use feedback to formalize system-level design decisions in a human-in-the-loop-process -- in order to produce better models. In particular this is done through: (i) metric design for tasks; and (ii) language model prompt design for refining model responses. We conduct two case studies of this approach for improving search query generation and dialog response generation, demonstrating the effectiveness of the use of system-level feedback. We show the combination of system-level feedback and instance-level feedback brings further gains, and that human written instance-level feedback results in more grounded refinements than GPT-3.5 written ones, underlying the importance of human feedback for building systems.Comment: 12 pages, 13 tables, 2 figure

Regulation of Neuronal Cell Death by c-Abl-Hippo/MST2 Signaling Pathway

BACKGROUND: Mammalian Ste20-like kinases (MSTs) are the mammalian homologue of Drosophila hippo and play critical roles in regulation of cell death, organ size control, proliferation and tumorigenesis. MSTs exert pro-apoptotic function through cleavage, autophosphorylation and in turn phosphorylation of downstream targets, such as Histone H2B and FOXO (Forkhead box O). Previously we reported that protein kinase c-Abl mediates oxidative stress-induced neuronal cell death through phosphorylating MST1 at Y433, which is not conserved among mammalian MST2, Drosophila Hippo and C.elegans cst-1/2. METHODOLOGY/PRINCIPAL FINDINGS: Using immunoblotting, in vitro kinase and cell death assay, we demonstrate that c-Abl kinase phosphorylates MST2 at an evolutionarily conserved site, Y81, within the kinase domain. We further show that the phosphorylation of MST2 by c-Abl leads to the disruption of the interaction with Raf-1 proteins and the enhancement of homodimerization of MST2 proteins. It thereby enhances the MST2 activation and induces neuronal cell death. CONCLUSIONS/SIGNIFICANCE: The identification of the c-Abl tyrosine kinase as a novel upstream activator of MST2 suggests that the conserved c-Abl-MST signaling cascade plays an important role in oxidative stress-induced neuronal cell death

Developing a hydrogel ink for creating reconfigurable 3D printed structures

Hydrogel has emerged as one of the most important biomaterials in biological and biomedical fields due to many superior properties, such as biocompatibility, high porosity, etc. Reconfigurability represents an appealing feature of the hydrogel structures whose shapes can be remodeled after they are printed. Existing reconfigurable hydrogel structures are mainly created by incorporating stimulus-active materials into the hydrogel precursor solution. After being crosslinked, the hydrogel structures change shapes when they are exposed to external stimuli due to the mismatch strain caused by non-uniform response to the external stimuli. However, this approach only allows the hydrogel structures to be reshaped into very limited number of configurations. In this study, we aim to develop a reconfigurable hydrogel ink. We use sodium alginate as a base material and ethanol and proanthocyanins as additives. The ethanol allows the ink to form a physical hydrogel after a structure is printed by lowering the temperature below the sol-to-gel transition temperature, while proanthocyanins will be used to boost the absorption of the near infrared laser light generated with a laser emitter. Gel-to-sol transition occurs when the local temperature is raised high enough. We have tested the effect of the additives and confirmed the existence of the sol-to-gel and gel-to-sol transitions. Our study paves a way for developing novel hydrogel ink formulations for creating many other types of hydrogel structures.Master of Science (Mechanical Engineering

KID-Review: Knowledge-Guided Scientific Review Generation with Oracle Pre-training

The surge in the number of scientific submissions has brought challenges to the work of peer review. In this paper, as a first step, we explore the possibility of designing an automated system, which is not meant to replace humans, but rather providing a first-pass draft for a machine-assisted human review process. Specifically, we present an end-to-end knowledge-guided review generation framework for scientific papers grounded in cognitive psychology research that a better understanding of text requires different types of knowledge. In practice, we found that this seemingly intuitive idea suffered from training difficulties. In order to solve this problem, we put forward an oracle pre-training strategy, which can not only make the Kid-Review better educated but also make the generated review cover more aspects. Experimentally, we perform a comprehensive evaluation (human and automatic) from different perspectives. Empirical results have shown the effectiveness of different types of knowledge as well as oracle pre-training. We make all code, relevant dataset available: https://github.com/Anonymous4nlp233/KIDReview as well as the Kid-Review system: http://nlpeer.reviews

Genetic characterization of three mitochondrial gene sequences of goat/sheep-derived coenurus cerebralis and cysticercus tenuicollis isolates in Inner Mongolia, China

Taenia multiceps and Taenia hydatigena are widely distributed tapeworms of canids. Due to a lack of genetic information on these two parasites in China, in this study we analyzed six coenurus cerebralis and two cysticercus tenuicollis cysts from goats or sheep in Inner Mongolia, northern China by amplifying three mitochondrial genes (cox1, nad4, and cytb). Two haplotypes were obtained at each locus for either of the two Taenia cestode species, with ten nucleotide sequences being novel. The degrees of genetic variations were 1.18%, 0.61% and 0.52% for coenurus cerebralis, and 0.24%, 0.46% and 0.35% for cysticercus tenuicollis at the cox1, nad4 and cytb loci, respectively. This is the first molecular description of animal-derived metacestodes of T. multiceps and T. hydatigena in Inner Mongolia, China. Novel nucleotide sequences might reflect endemic genetic characterization of the two cestodes. The present data are useful to explore the biological and epidemiological significance of intra-specific variations within both Taenia cestodes