34 research outputs found
Role of JNK and contribution of p53 into growth potential of mesenchymal progenitor cells in vitro
Specifi c JNK and p53 inhibitors stimulated the formation of fi broblast colonies (CFU-F) and clusters (ClFU-F) and increased proliferative activity of mesenchymal progenitor cells. No effects of inhibitors of JNK and p53 on differentiation of progenitor elements were revealed
Role of JNK and contribution of p53 into growth potential of mesenchymal progenitor cells in vitro
Specifi c JNK and p53 inhibitors stimulated the formation of fi broblast colonies (CFU-F) and clusters (ClFU-F) and increased proliferative activity of mesenchymal progenitor cells. No effects of inhibitors of JNK and p53 on differentiation of progenitor elements were revealed
Role of cAMP- and IKK-2-dependent signaling pathways in functional stimulation of mesenchymal progenitor cells with alkaloid songorine
The role of cAMP- and IKK-2-dependent pathways in stimulation of the growth capacity of mesenchymal progenitor cells with alkaloid songorine was studied in vitro. Inhibitors of adenylate cyclase and IKK-2 were shown to abolish the increase in proliferative activity of progenitor cells. Moreover, blockade of the inhibitory kinase complex was accompanied by a decrease in the intensity of progenitor cell differentiation