Oncogenic Effect of Helicobacter Pylori, Prevention and Treatment Approach- A Review

Chronic gastritis has been long known to be related with gastric cancer. Most importantly, for most instances of gastric cancer, the fundamental reason for gastritis is ascribed to H. Pylori infection. Understanding the pathophysiologic mechanism that lead to gastric cancer is important for screening, prevention and treatment purposes. Gastritis can activate an oncogenic mechanism via the Correa cascade. However, studiePooja Dosieahs reported that the risk of gastric malignancy increments fundamentally when gastritis is combined with H. Pylori contamination. Other than the upper gastrointestinal tract, H. Pylori is additionally engaged with the pathogenesis of colorectal cancer. Treatment aiming at eradicating H. Pylori through the appropriate regimens is important. The triple standard therapy or the quadruple therapies are the universally accepted regimens. All infected patients should be subjected to H. Pylori treatment. An essential issue is to recognize those individuals at a greater possibility of developing H. Pylori infection including those with peptic ulcer illness, previous history of peptic ulcer disease, low-grade gastric mucosa-related lymphoid tissue (MALT) lymphoma, or a past history of endoscopic resection of early gastric disease

Liquid chromatography coupled with time-of-flight and ion trap mass spectrometry for qualitative analysis of herbal medicines

AbstractWith the expansion of herbal medicine (HM) market, the issue on how to apply up-to-date analytical tools on qualitative analysis of HMs to assure their quality, safety and efficacy has been arousing great attention. Due to its inherent characteristics of accurate mass measurements and multiple stages analysis, the integrated strategy of liquid chromatography (LC) coupled with time-of-flight mass spectrometry (TOF-MS) and ion trap mass spectrometry (IT-MS) is well-suited to be performed as qualitative analysis tool in this field. The purpose of this review is to provide an overview on the potential of this integrated strategy, including the review of general features of LC-IT-MS and LC-TOF-MS, the advantages of their combination, the common procedures for structure elucidation, the potential of LC-hybrid-IT-TOF/MS and also the summary and discussion of the applications of the integrated strategy for HM qualitative analysis (2006–2011). The advantages and future developments of LC coupled with IT and TOF-MS are highlighted

Enhancement of polar phases in PVDF by forming PVDF/SiC nanowire composite

Different contents of silicon carbide (SiC) nanowires were mixed with Poly(vinylidene fluoride) (PVDF) to facilitate the polar phase crystallization. It was shown that the annealing temperature and SiC content affected on the phase and crystalline structures of PVDF/SiC samples. Furthermore, the addition of SiC nanowire enhanced the transformation of non-polar α phase to polar phases and increased the relative fraction of β phase in PVDF. Due to the nucleating agent mechanism of SiC nanowires, the ion-dipole interaction between the negatively charged surface of SiC nanowires and the positive CH2 groups in PVDF facilitated the formation of polar phases in PVDF