Antecedents and Consequences of User Co-Production in Information System Development Projects

A significant number of information system development (ISD) projects fail to achieve their predefined goals on time and/or within budget. Many organizations recognize that users can engage in projects to minimize the difficulties in effectively controlling the project and maximize the value created; therefore, user co-production is a crucial for organizations to enhance the effectiveness of ISD project. This study attempts to understand the antecedents and consequences of user co-production in ISD project. As a key contribution, we posit that user co-production is influenced by social capitals between users and developers. We then postulate that user co-production determines the project outcomes, which are shaped by system quality, user satisfaction and project performance. Data were gathered from a questionnaire survey of 103 pairs of user representatives and developers. Our results show that project outcomes are significantly influenced by user co-production. Furthermore, social capitals between user representatives and developers have positively significant influence on user co-production

Stationary Light Pulses in Cold Atomic Media

Stationary light pulses (SLPs), i.e., light pulses without motion, are formed via the retrieval of stored probe pulses with two counter-propagating coupling fields. We show that there exist non-negligible hybrid Raman excitations in media of cold atoms that prohibit the SLP formation. We experimentally demonstrate a method to suppress these Raman excitations and realize SLPs in laser-cooled atoms. Our work opens the way to SLP studies in cold as well as in stationary atoms and provides a new avenue to low-light-level nonlinear optics.Comment: 4 pages, 4 figure

Complementary Therapy with Traditional Chinese Medicine for Ischemic Stroke

Stroke has remained the leading cause of morbidity or mortality worldwide over the past decade. Stroke survivors suffer various degrees of disability and also contribute to the large socioeconomic disease burden. Traditional Chinese medicine (TCM) serves as an important alternative or complementary therapy in many countries. This chapter aims to explore the utility of TCM for ischemic stroke, including a review of recent literature on the mechanisms of herbal medicine and acupuncture therapy on ischemic stroke, a summary of clinical trial results for the safety and efficacy of acupuncture, and finally a discussion of acupuncture as a preventive therapy for ischemic stroke in clinical practice. On the basis of these reports, more and more scientific evidences suggest that TCM use was safe for ischemic stroke at acute and subacute stages. Moreover, TCM has benefit for stroke recovery as well as it reduces the likelihood of hospital readmission for cardiovascular or subsequent stroke events

High-Mobility Pentacene-Based Thin-Film Transistors With a Solution-Processed Barium Titanate Insulator

Abstract—Pentacene-based organic thin-film transistors (OTFTs) with solution-processed barium titanate (Ba1.2Ti0.8O3) as a gate insulator are demonstrated. The electrical properties of pentacene-based TFTs show a high field-effect mobility of 8.85 cm2 · V−1 · s−1, a low threshold voltage of −1.89 V, and a low subthreshold slope swing of 310 mV/decade. The chemical composition and binding energy of solution-processed barium titanate thin films are analyzed through X-ray photoelectron spectroscopy. The matching surface energy on the surface of the barium titanate thin film is 43.12 mJ · m−2, which leads to Stranski–Krastanov mode growth, and thus, high mobility is exhibited in pentacene-based TFTs. Index Terms—Barium titanate, high field-effect mobility, high permittivity, organic thin-filmtransistor (OTFT), solution process

Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation.

PKM2 is a key metabolic enzyme central to glucose metabolism and energy expenditure. Multiple stimuli regulate PKM2's activity through allosteric modulation and post-translational modifications. Furthermore, PKM2 can partner with KDM8, an oncogenic demethylase and enter the nucleus to serve as a HIF1α co-activator. Yet, the mechanistic basis of the exon-10 region in allosteric regulation and nuclear translocation remains unclear. Here, we determined the crystal structures and kinetic coupling constants of exon-10 tumor-related mutants (H391Y and R399E), showing altered structural plasticity and reduced allostery. Immunoprecipitation analysis revealed increased interaction with KDM8 for H391Y, R399E, and G415R. We also found a higher degree of HIF1α-mediated transactivation activity, particularly in the presence of KDM8. Furthermore, overexpression of PKM2 mutants significantly elevated cell growth and migration. Together, PKM2 exon-10 mutations lead to structure-allostery alterations and increased nuclear functions mediated by KDM8 in breast cancer cells. Targeting the PKM2-KDM8 complex may provide a potential therapeutic intervention

Using Hybrid Angle/Distance Information for Distributed Topology Control in Vehicular Sensor Networks

In a vehicular sensor network (VSN), the key design issue is how to organize vehicles effectively, such that the local network topology can be stabilized quickly. In this work, each vehicle with on-board sensors can be considered as a local controller associated with a group of communication members. In order to balance the load among the nodes and govern the local topology change, a group formation scheme using localized criteria is implemented. The proposed distributed topology control method focuses on reducing the rate of group member change and avoiding the unnecessary information exchange. Two major phases are sequentially applied to choose the group members of each vehicle using hybrid angle/distance information. The operation of Phase I is based on the concept of the cone-based method, which can select the desired vehicles quickly. Afterwards, the proposed time-slot method is further applied to stabilize the network topology. Given the network structure in Phase I, a routing scheme is presented in Phase II. The network behaviors are explored through simulation and analysis in a variety of scenarios. The results show that the proposed mechanism is a scalable and effective control framework for VSNs

Complementary and Alternative Therapy with Traditional Chinese Medicine for Infertility

Infertility results in a country with a low birth rate and an aging population, and thus there is vested interest in treating this problem by using both complementary and alternative therapies, in addition to conventional western medicine. Traditional Chinese medicine (TCM) has been widely used for healthcare in the Eastern world for thousands of years. This chapter describes the evidence to support the role of TCM in the management of male and female infertility

Complementary Therapy with Traditional Chinese Medicine for Polycystic Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is a common, heterogeneous, complex, endocrinopathic condition that causes menstrual dysfunction and infertility in women. Traditional Chinese medicine (TCM) has been widely used for PCOS in Far-East countries for thousands of years. There are significant advantages in treating PCOS with TCM. This chapter aims to investigate the current developments in TCM therapy for PCOS