Bis(μ-naphthalene-1,8-dicarboxyl­ato-κ2 O 1:O 8)bis­[aqua­bis­(N,N′-dimethyl­formamide-κO)copper(II)]

In the centrosymmetric dinuclear title complex, [Cu2(C12H6O4)2(C3H7NO)4(H2O)2], the coordination environment of each Cu(II) atom displays a distorted CuO5 square-pyramidal geometry, which is formed by two carboxyl­ate O atoms of two μ-1,8-nap ligands (1,8-nap is naphthalene-1,8-dicarboxyl­ate), two O atoms of two DMF (DMF is N,N′-dimethyl­formamide) and one coordinated water mol­ecule. The Cu—O distances involving the four O atoms in the square plane are in the range 1.9501 (11)–1.9677 (11) Å, with the Cu atom lying nearly in the plane [deviation = 0.0726 (2) Å]. The axial O atom occupies the peak position with a Cu—O distance of 2.885 (12) Å, which is significantly longer than the rest of the Cu—O distances. Each 1,8-nap ligand acts as bridge, linking two CuII atoms into a dinuclear structure. Inter­molecular O—H⋯O and C—H⋯O hydrogen-bonding inter­actions consolidate the structure

The Role of Molecular Imaging in the Diagnosis and Management of Neuropsychiatric Disorders

Neuropsychiatric disorders are becoming a major socioeconomic burden to modern society. In recent years, a dramatic expansion of tools has facilitated the study of the molecular basis of neuropsychiatric disorders. Molecular imaging has enabled the noninvasive characterization and quantification of biological processes at the cellular, tissue, and organism levels in intact living subjects. This technology has revolutionized the practice of medicine and has become critical to quality health care. New advances in research on molecular imaging hold promise for personalized medicine in neuropsychiatric disorders, with adjusted therapeutic doses, predictable responses, reduced adverse drug reactions, early diagnosis, and personal health planning. In this paper, we discuss the development of radiotracers for imaging dopaminergic, serotonergic, and noradrenergic systems and β-amyloid plaques. We will underline the role of molecular imaging technologies in various neuropsychiatric disorders, describe their unique strengths and limitations, and suggest future directions in the diagnosis and management of neuropsychiatric disorders

EFFECT OF EIGHT WEEKS VIBRATION TRAINING ON THE LOWER LIMB BASIC ABILITY AND ATHLETIC PERFORMANCE OF GYMNASTS

The purpose of this study explores the effects of 8 weeks vibration training on the basic ability (explosive power, speed, agility) and athletic performance (backward somersault) of the lower limbs of gymnasts. Sixteen gymnasts were randomly divided into vibration training group (VT) and control group (CON). Participants were trained for eight weeks and performed countermovement jump (CMJ), sprints, shuttle run, and backward somersault tests before the training, after 4 weeks, and 8 weeks of training. The significant level was set to α = .05. The results showed that the speed of VT increased significantly after 4 weeks of training, and the speed and agility of VT increased significantly after 8 weeks of training (p \u3c.05). In conclusion, Gymnasts can improve their speed ability through 4 weeks of vibration training, and 8 weeks vibration training can improve their speed and agility

An Improved FastSLAM System Based on Distributed Structure for Autonomous Robot Navigation

Fast simultaneous localization and mapping (FastSLAM) is an efficient algorithm for autonomous navigation of mobile vehicle. However, FastSLAM must reconfigure the entire vehicle state equation when the feature points change, which causes an exponential growth in quantities of computation and difficulties in isolating potential faults. In order to overcome these limitations, an improved FastSLAM, based on the distributed structure, is developed in this paper. There are two state estimation parts designed in this improved FastSLAM. Firstly, a distributed unscented particle filter is used to avoid reconfiguring the entire system equation in the vehicle state estimation part. Secondly, in the landmarks estimation part, the observation model is designed as a linear one to update the landmarks states by using the linear observation errors. Then, the convergence of the proposed and improved FastSLAM algorithm is given in the sense of mean square. Finally, the simulation results show that the proposed distributed algorithm could reduce the computational complexity with high accuracy and high fault-tolerance performance

Textural and biochemical changes of scallop Patinopecten yessoensis adductor muscle during low-temperature long-time (LTLT) processing

In this study, the effects of low-temperature long-time (LTLT) processing on the quality of Patinopecten yessoensis adductor muscle (PYAM) were investigated at 55°C. The texture of processed PYAM was characterized by textural profile analysis (TPA), and significant increases of cook loss, hardness, and shear force with time during LTLT processing were observed. The degradation of structural proteins was analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), and fragments with molecular weights of 208 kDa (myosin heavy chain, MHC), 97 kDa (paramyosin) and 35–40 kDa, respectively, were among the main products. Chemical characterization revealed elevated levels of activity in cathepsin L and caspase-3 and oxidation of proteins and lipids. Electron spin resonance spin trapping indicated reactive oxygen species (ROS) production in the PYAM during LTLT processing. Based on these results, it is proposed that the sequence of events in PYAM during LTLT processing includes ROS→ endogenous enzyme (involving caspase-3 and cathepsin L) activation →protein degradation→quality changes (texture and color). This revelation helps to further our understanding of the LTLT processing of PYAM, which would lead to better quality control for PYAM products

Dissecting the chromatin interactome of microRNA genes

Abstract Our knowledge of the role of higher-order chromatin structures in transcription of microRNA genes (MIRs) is evolving rapidly. Here we investigate the effect of 3D architecture of chromatin on the transcriptional regulation of MIRs. We demonstrate that MIRs have transcriptional features that are similar to protein-coding genes. RNA polymerase II–associated ChIA-PET data reveal that many groups of MIRs and protein-coding genes are organized into functionally compartmentalized chromatin communities and undergo coordinated expression when their genomic loci are spatially colocated. We observe that MIRs display widespread communication in those transcriptionally active communities. Moreover, miRNA–target interactions are significantly enriched among communities with functional homogeneity while depleted from the same community from which they originated, suggesting MIRs coordinating function-related pathways at posttranscriptional level. Further investigation demonstrates the existence of spatial MIR–MIR chromatin interacting networks. We show that groups of spatially coordinated MIRs are frequently from the same family and involved in the same disease category. The spatial interaction network possesses both common and cell-specific subnetwork modules that result from the spatial organization of chromatin within different cell types. Together, our study unveils an entirely unexplored layer of MIR regulation throughout the human genome that links the spatial coordination of MIRs to their co-expression and function.</jats:p