Tetra­kis(μ-4-methoxy­benzoato)bis­[(4-methoxy­benzoato)(1,10-phenan­throline)terbium(III)]

In the title dinuclear complex, [Tb2(C8H7O3)6(C12H8N2)2], each TbIII ion is eight-coordinated by two N atoms from a 1,10-phenanthroline ligand and six O atoms from the carboxyl­ate groups of five 4-methoxy­benzoate ligands in a distorted square-anti­prismatic geometry. All six 4-methoxy­benzoate ligands act in a bidentate mode, two coordinating to one Tb center each and the other four bridging two Tb centers [Tb⋯Tb separation = 4.3144 (6) Å]. In the crystal, inter­molecular π–π inter­actions between the aromatic rings of 1,10-phenanthroline and 4-methoxy­benzoate ligands [centroid–centroid distance = 3.742 (9) Å] link two mol­ecules into a centrosymmetric dimer. Weak inter­molecular C—H⋯O hydrogen bonds help to consolidate the crystal packing

Comparative analysis of port efficiency in Yangtze River Delta and Pearl River Delta: a meta Dynamic D.D.F. approach

The Yangtze River Delta and Pearl River Delta are two regions with the highest level of economic development in China, and their port development is at the forefront of the country. This study measures the efficiency of 23 major ports in the two deltas from 2010 to 2018 using the meta Dynamic Directional Distance Function (D.D.F.) model and discusses the technology gap and the reasons for inefficiency of the ports. The research results show that 80% of the ports in these two deltas are inefficient. The Yangtze River Delta’s port efficiency is higher than that of the Pearl River Delta, but the internal efficiency difference of the Yangtze River Delta port cluster is more significant. The efficiency ranking of most ports is inconsistent under the meta-frontier (M.F.) and group frontier (G.F.), and the average technology gap ratio (T.G.R.) of ports in the Pearl River Delta gradually exceeds that in the Yangtze River Delta. The inefficiency of ports in the Pearl River Delta is caused by input factors, and the inefficiency of ports in the Yangtze River Delta is also related to the containerisation level

Expressions and clinic significance of miRNA-143, miRNA- 34A, miRNA-944, miRNA-101 and miRNA-218 in cervical cancer tissues

Purpose: To search for novel biomarkers for early diagnosis of cervical cancer, as well as novel therapeutic target for cervical cancer.Methods: A total of 96 cervical tissue specimens were collected from patients in the Second Affiliated Hospital of Zhengzhou University, out of which 10 were normal control. The remaining specimens (86) were cervical cancer specimens and were divided into 4 groups (A - D) based on tumor-biomarker levels of CA125 and SCC. Quantitative real-time polymerase chain reaction technology (qRT-PCR) was used to detect the expressions of miRNA-143, miRNA-34A, miRNA-944, miRNA-101 and miRNA-218 in the cervical cancer tissues.Results: The levels of CA125 (U/mL) and SCC (ug/L) expressed in normal control group and groups A - D were 11.75 and 0.73 (n = 10), 382 and 2.72 (n = 25), 912.9 and 3.93 (n = 21), 1675 and 5.87 (n = 29), and 2120 and 6.66 (n = 11), respectively. Furthermore, qRT-PCR results showed that the expressions of miRNA-944 and miRNA-218 in cervical cancer tissues were markedly up-regulated compared to normal control tissues (p < 0.01). In contrast, the expression level of miRNA-143, miRNA-34A, and miRNA-101 were significantly decreased (p < 0.01).Conclusion: The biomarkers, miRNA-143, miRNA-34A, miRNA-944, miRNA-101 and miRNA-218, can be considered novel for early diagnosis of cervical cancer.Keywords: Cervical cancer, Biomarkers, miRNA-143, miRNA-34A, miRNA-944, miRNA-101, miRNA- 21

4-Methyl-2-oxo-2,3-dihydro-1-benzopyran-7-yl benzene­sulfonate

The title compound, C16H12O5S, is a derivative of coumarin. The dihedral angle between the coumarin ring system and the phenyl ring is 65.9 (1)°. In the crystal structure, mol­ecules are linked by weak C—H⋯O hydrogen bonding to form molecular ribbons

Why Focal Firms Share Information? A Study of the Effects of Power and Information Technology Competence

Supply chain management has become an important issue for Taiwan\u27s manufacturing industry due to escalating global competition. Virtual vertical integration is an important issue in supply chain management. Because organizations only have limited resources, they pursue long-term partnership with specific transaction partners. They share information to improve visibility, speed responses to markets, and reduce costs from information distortion or information asymmetry. This study empirically explores the factors affecting inter-organizational information sharing from the perspective of focal firms. 1,000 questionnaires were administered to top 1,000 manufacturing companies in Taiwan, with 139 valid responses. The results show that partner\u27s power and relation-specific asset investments positively affect inter-organizational information sharing. On the other hand, the partner\u27s power does not significantly affect the organization\u27s relation-specific investments. This study further investigates the moderating role of information technology competence. The result indicates that when an organization has lower information technology competence, the relationship between the partner\u27s power and relation-specific investments is significant. Implications and discussion are then provided

Diaqua­bis(N,N′-dibenzyl­ethane-1,2-diamine-κ2 N,N′)nickel(II) dichloride N,N-dimethyl­formamide solvate

The asymmetric unit of the title complex, [Ni(C16H20N2)2(H2O)2]Cl2·C3H7NO, consists of two NiII atoms, each lying on an inversion center, two Cl anions, two N,N′-dibenzyl­ethane-1,2-diamine ligands, two coordinated water mol­ecules and one N,N-dimethyl­formamide solvent mol­ecule. Each NiII atom is six-coordinated in a distorted octa­hedral coordination geometry, with the equatorial plane formed by four N atoms and the axial positions occupied by two water mol­ecules. The complex mol­ecules are linked into a chain along [001] by N—H⋯Cl, N—H⋯O and O—H⋯Cl hydrogen bonds. The C atoms and H atoms of the solvent mol­ecule are disordered over two sites in a ratio of 0.52 (2):0.48 (2)

Histone deacetylase inhibitor valproic acid suppresses the growth and increases the androgen responsiveness of prostate cancer cells.

We identified the molecular target by histone deacetylase (HDAC) inhibitors for exploring their potential prostate cancer (PCa) therapy. Upon HDAC inhibitors-treatment, LNCaP cell growth was suppressed, correlating with increased cellular prostatic acid phosphatase (cPAcP) expression, an authentic protein tyrosine phosphatase. In those cells, ErbB-2 was dephosphorylated, histone H3/H4 acetylation and methylation increased and cyclin proteins decreased. In PAcP shRNA-transfected C-81 cells, valproic acid (VPA) efficacy of growth suppression was diminished. Further, VPA pre-treatment enhanced androgen responsiveness of C-81, C4-2 and MDA PCa2b-AI cells. Thus, cPAcP expression is involved in growth suppression by HDAC inhibitors in PCa cells, and VPA pre-treatments increase androgen responsiveness

(2-{[1-(Pyridin-2-yl)ethyl­idene]amino­meth­yl}pyridine-κ3 N,N′,N′′)bis­(thio­cyanato-κN)zinc

The complete mol­ecule of the title mononuclear zinc(II) complex, [Zn(NCS)2(C13H13N3)], is generated by crystallographic twofold symmetry, with the metal atom lying on the rotation axis. The pendant methyl group of the ligand is statistically disordered over two sites. The Zn2+ cation is coordinated by the N,N′,N′′-tridentate Schiff base ligand, and by two thio­cyanate N atoms, forming a distorted ZnN5 trigonal–bipyramidal geometry

Benzyl 2,5-dioxopyrrolidin-1-yl carbonate

The asymmetric unit of the title compound, C12H11NO5, contains two independent mol­ecules with similar geometric parameters but different orientations of the phenyl rings. The mol­ecular packing is stabilized by weak nonclassical C—H⋯O hydrogen-bonding inter­actions