Accurate Diagnosis of Colorectal Cancer Based On Histopathology Images Using Artificial Intelligence

Background: Accurate and robust pathological image analysis for colorectal cancer (CRC) diagnosis is time-consuming and knowledge-intensive, but is essential for CRC patients’ treatment. The current heavy workload of pathologists in clinics/hospitals may easily lead to unconscious misdiagnosis of CRC based on daily image analyses. Methods: Based on a state-of-the-art transfer-learned deep convolutional neural network in artificial intelligence (AI), we proposed a novel patch aggregation strategy for clinic CRC diagnosis using weakly labeled pathological whole-slide image (WSI) patches. This approach was trained and validated using an unprecedented and enormously large number of 170,099 patches, \u3e 14,680 WSIs, from \u3e 9631 subjects that covered diverse and representative clinical cases from multi-independent-sources across China, the USA, and Germany. Results: Our innovative AI tool consistently and nearly perfectly agreed with (average Kappa statistic 0.896) and even often better than most of the experienced expert pathologists when tested in diagnosing CRC WSIs from multicenters. The average area under the receiver operating characteristics curve (AUC) of AI was greater than that of the pathologists (0.988 vs 0.970) and achieved the best performance among the application of other AI methods to CRC diagnosis. Our AI-generated heatmap highlights the image regions of cancer tissue/cells. Conclusions: This first-ever generalizable AI system can handle large amounts of WSIs consistently and robustly without potential bias due to fatigue commonly experienced by clinical pathologists. It will drastically alleviate the heavy clinical burden of daily pathology diagnosis and improve the treatment for CRC patients. This tool is generalizable to other cancer diagnosis based on image recognition

Measurement of the final states ωπ0\omega \pi^0, ρη\rho \eta, and ρη′\rho \eta^{'} from \psip electromagnetic decays and \ee annihilations

Cross sections and form factors for \ee \to \wpi, $\rho\eta$, and \rho\etap at center of mass energies of 3.650, 3.686, and 3.773 GeV are measured using data samples collected with the BESII detector at the BEPC. Also, the branching fractions of \psi(2S) \rar \wpi, $\rho\eta$, and \rho\etap are determined to be $(1.87^{+0.68}_{-0.62}\pm0.28)\times 10^{-5}$, $(1.78^{+0.67}_{-0.62}\pm0.17)\times 10^{-5}$, and $(1.87^{+1.64}_{-1.11}\pm0.33)\times10^{-5}$, respectively.Comment: 8 pages, 4 figures, 4 table

Observation of an anomalous line shape of the η′π+π−\eta^{\prime}\pi^{+}\pi^{-} mass spectrum near the ppˉp\bar{p} mass threshold in J/ψ→γη′π+π−J/\psi\rightarrow\gamma\eta^{\prime}\pi^{+}\pi^{-}

Using $1.09\times10^{9}$ $J/\psi$ events collected by the BESIII experiment in 2012, we study the $J/\psi\rightarrow\gamma\eta^{\prime}\pi^{+}\pi^{-}$ process and observe a significant abrupt change in the slope of the $\eta^{\prime}\pi^{+}\pi^{-}$ invariant mass distribution at the proton-antiproton ($p\bar{p}$) mass threshold. We use two models to characterize the $\eta^{\prime}\pi^{+}\pi^{-}$ line shape around $1.85~\text{GeV}/c^{2}$: one which explicitly incorporates the opening of a decay threshold in the mass spectrum (Flatt\'{e} formula), and another which is the coherent sum of two resonant amplitudes. Both fits show almost equally good agreement with data, and suggest the existence of either a broad state around $1.85~\text{GeV}/c^{2}$ with strong couplings to $p\bar{p}$ final states or a narrow state just below the $p\bar{p}$ mass threshold. Although we cannot distinguish between the fits, either one supports the existence of a $p\bar{p}$ molecule-like state or bound state with greater than $7\sigma$ significance

Search for the decay J/ψ→γ+invisibleJ/\psi\to\gamma + \rm {invisible}

We search for $J/\psi$ radiative decays into a weakly interacting neutral particle, namely an invisible particle, using the $J/\psi$ produced through the process $\psi(3686)\to\pi^+\pi^-J/\psi$ in a data sample of $(448.1\pm2.9)\times 10^6$ $\psi(3686)$ decays collected by the BESIII detector at BEPCII. No significant signal is observed. Using a modified frequentist method, upper limits on the branching fractions are set under different assumptions of invisible particle masses up to 1.2 $\mathrm{\ Ge\kern -0.1em V}/c^2$. The upper limit corresponding to an invisible particle with zero mass is 7.0$\times 10^{-7}$ at the 90\% confidence level

Observation and study of the decay J/ψ→ϕηη′J/\psi\rightarrow\phi\eta\eta'

We report the observation and study of the decay $J/\psi\rightarrow\phi\eta\eta'$ using $1.3\times{10^9}$ $J/\psi$ events collected with the BESIII detector. Its branching fraction, including all possible intermediate states, is measured to be $(2.32\pm0.06\pm0.16)\times{10^{-4}}$. We also report evidence for a structure, denoted as $X$, in the $\phi\eta'$ mass spectrum in the $2.0-2.1$ GeV/$c^2$ region. Using two decay modes of the $\eta'$ meson ($\gamma\pi^+\pi^-$ and $\eta\pi^+\pi^-$), a simultaneous fit to the $\phi\eta'$ mass spectra is performed. Assuming the quantum numbers of the $X$ to be $J^P = 1^-$, its significance is found to be 4.4$\sigma$, with a mass and width of $(2002.1 \pm 27.5 \pm 21.4)$ MeV/$c^2$ and $(129 \pm 17 \pm 9)$ MeV, respectively, and a product branching fraction $\mathcal{B}(J/\psi\rightarrow\eta{}X)\times{}\mathcal{B}(X\rightarrow\phi\eta')=(9.8 \pm 1.2 \pm 1.7)\times10^{-5}$. Alternatively, assuming $J^P = 1^+$, the significance is 3.8$\sigma$, with a mass and width of $(2062.8 \pm 13.1 \pm 7.2)$ MeV/$c^2$ and $(177 \pm 36 \pm 35)$ MeV, respectively, and a product branching fraction $\mathcal{B}(J/\psi\rightarrow\eta{}X)\times{}\mathcal{B}(X\rightarrow\phi\eta')=(9.6 \pm 1.4 \pm 2.0)\times10^{-5}$. The angular distribution of $J/\psi\rightarrow\eta{}X$ is studied and the two $J^P$ assumptions of the $X$ cannot be clearly distinguished due to the limited statistics. In all measurements the first uncertainties are statistical and the second systematic.Comment: 10 pages, 6 figures and 4 table

Observation of hch_{c} radiative decay hc→γη′h_{c} \rightarrow \gamma \eta' and evidence for hc→γηh_{c} \rightarrow \gamma \eta

A search for radiative decays of the $P$-wave spin singlet charmonium resonance $h_c$ is performed based on $4.48 \times 10^{8}$ $\psi'$ events collected with the BESIII detector operating at the BEPCII storage ring. Events of the reaction channels $h_{c} \rightarrow \gamma \eta'$ and $\gamma \eta$ are observed with a statistical significance of $8.4 \sigma$ and $4.0 \sigma$, respectively, for the first time. The branching fractions of $h_{c} \rightarrow \gamma \eta'$ and $h_{c} \rightarrow \gamma \eta$ are measured to be $\mathcal{B}(h_{c} \rightarrow \gamma \eta')=(1.52 \pm 0.27 \pm 0.29)\times10^{-3}$ and $\mathcal{B}(h_{c} \rightarrow \gamma \eta)=(4.7 \pm 1.5 \pm 1.4)\times10^{-4}$, respectively, where the first errors are statistical and the second are systematic uncertainties.Comment: 7 pages, 2 figure

Observation of a charged charmoniumlike structure in e+e−→(D∗Dˉ∗)±π∓e^+e^- \to (D^{*} \bar{D}^{*})^{\pm} \pi^\mp at s=4.26\sqrt{s}=4.26GeV

We study the process $e^+e^- \to (D^{*} \bar{D}^{*})^{\pm} \pi^\mp$ at a center-of-mass energy of 4.26GeV using a 827pb$^{-1}$ data sample obtained with the BESIII detector at the Beijing Electron Positron Collider. Based on a partial reconstruction technique, the Born cross section is measured to be $(137\pm9\pm15)$pb. We observe a structure near the $(D^{*} \bar{D}^{*})^{\pm}$ threshold in the $\pi^\mp$ recoil mass spectrum, which we denote as the $Z^{\pm}_c(4025)$. The measured mass and width of the structure are $(4026.3\pm2.6\pm3.7)$MeV/c$^2$ and $(24.8\pm5.6\pm7.7)$MeV, respectively. Its production ratio $\frac{\sigma(e^+e^-\to Z^{\pm}_c(4025)\pi^\mp \to (D^{*} \bar{D}^{*})^{\pm} \pi^\mp)}{\sigma(e^+e^-\to (D^{*} \bar{D}^{*})^{\pm} \pi^\mp)}$ is determined to be $0.65\pm0.09\pm0.06$. The first uncertainties are statistical and the second are systematic.Comment: 7 pages, 4 figures, 1 table; version accepted to be published in PR