Neutron depolarization studies of Pd-Ni-Fe-P alloy

Bulk metallic glasses based on the quaternary alloy Pd-Ni-Fe-P exhibit interesting phase behavior depending on temperature and applied magnetic field. Previous work has suggested that a range of magnetic phases including paramagnetic, superparamagnetic, ferromagnetic and spin glass can be observed in this system. We have applied one dimensional neutron depolarization to explore the correlation of magnetic moments in Pd40Ni22.5Fe17.5P20 alloy as a function of temperature and applied magnetic field. The results provided evidence for correlation lengths of ~ 200 Å. The nature of the correlations and the formation mechanism of the induced ferromagnetic phase are discusse

Mutual synchronization and clustering in randomly coupled chaotic dynamical networks

We introduce and study systems of randomly coupled maps (RCM) where the relevant parameter is the degree of connectivity in the system. Global (almost-) synchronized states are found (equivalent to the synchronization observed in globally coupled maps) until a certain critical threshold for the connectivity is reached. We further show that not only the average connectivity, but also the architecture of the couplings is responsible for the cluster structure observed. We analyse the different phases of the system and use various correlation measures in order to detect ordered non-synchronized states. Finally, it is shown that the system displays a dynamical hierarchical clustering which allows the definition of emerging graphs.Comment: 13 pages, to appear in Phys. Rev.

Vertical transport and electroluminescence in InAs/GaSb/InAs structures: GaSb thickness and hydrostatic pressure studies

We have measured the current-voltage (I-V) of type II InAs/GaSb/InAs double heterojunctions (DHETs) with 'GaAs like' interface bonding and GaSb thickness between 0-1200 \AA. A negative differential resistance (NDR) is observed for all DHETs with GaSb thickness $>$ 60 \AA below which a dramatic change in the shape of the I-V and a marked hysteresis is observed. The temperature dependence of the I-V is found to be very strong below this critical GaSb thickness. The I-V characteristics of selected DHETs are also presented under hydrostatic pressures up to 11 kbar. Finally, a mid infra-red electroluminescence is observed at 1 bar with a threshold at the NDR valley bias. The band profile calculations presented in the analysis are markedly different to those given in the literature, and arise due to the positive charge that it is argued will build up in the GaSb layer under bias. We conclude that the dominant conduction mechanism in DHETs is most likely to arise out of an inelastic electron-heavy-hole interaction similar to that observed in single heterojunctions (SHETs) with 'GaAs like' interface bonding, and not out of resonant electron-light-hole tunnelling as proposed by Yu et al. A Zener tunnelling mechanism is shown to contribute to the background current beyond NDR.Comment: 8 pages 12 fig

A superior drug carrier – aponeocarzinostatin in partially unfolded state fully protects the labile antitumor enediyne

<p>Abstract</p> <p>Background</p> <p>Neocarzinostatin is a potent antitumor drug consisting of an enediyne chromophore and a protein carrier.</p> <p>Methods</p> <p>We characterized an intermediate in the equilibrium unfolding pathway of aponeocarzinostatin, using a variety of biophysical techniques including 1-anilino-8-napthalene sulfonate binding studies, size-exclusion fast protein liquid chromatography, intrinsic tryptophan fluorescence, circular dichroism, and ¹H-¹⁵N heteronuclear single quantum coherence spectroscopy.</p> <p>Results</p> <p>The partially unfolded protein is in molten globule-like state, in which ~60% and ~20% tertiary and secondary structure is disrupted respectively. Despite lacking a fully coordinated tertiary structure for assembling a functional binding cleft, the protein in molten globule-like state is still able to fully protect the labile chromophore. Titration of chromophore leads the partially denatured apoprotein to fold into its native state.</p> <p>Conclusion</p> <p>These findings bring insight into conserving mechanism of neocarzinostatin under harsh environment, where even the partially denatured apoprotein exhibits protective effect, confirming the superiority of the drug carrier.</p

Global Incidence and mortality of oesophageal cancer and their correlation with socioeconomic indicators temporal patterns and trends in 41 countries

Oesophageal cancers (adenocarcinomas [AC] and squamous cell carcinomas [SCC]) are characterized by high incidence/mortality in many countries. We aimed to delineate its global incidence and mortality, and studied whether socioeconomic development and its incidence rate were correlated. The age-standardized rates (ASRs) of incidence and mortality of this medical condition in 2012 for 184 nations from the GLOBOCAN database; national databases capturing incidence rates, and the WHO mortality database were examined. Their correlations with two indicators of socioeconomic development were evaluated. Joinpoint regression analysis was used to generate trends. The ratio between the ASR of AC and SCC was strongly correlated with HDI (r = 0.535 [men]; r = 0.661 [women]) and GDP (r = 0.594 [men]; r = 0.550 [women], both p &lt; 0.001). Countries that reported the largest reduction in incidence in male included Poland (Average Annual Percent Change [AAPC] = −7.1, 95%C.I. = −12,−1.9) and Singapore (AAPC = −5.8, 95%C.I. = −9.5,−1.9), whereas for women the greatest decline was seen in Singapore (AAPC = −12.3, 95%C.I. = −17.3,−6.9) and China (AAPC = −5.6, 95%C.I. = −7.6,−3.4). The Philippines (AAPC = 4.3, 95%C.I. = 2,6.6) and Bulgaria (AAPC = 2.8, 95%C.I. = 0.5,5.1) had a significant mortality increase in men; whilst Columbia (AAPC = −6.1, 95%C.I. = −7.5,−4.6) and Slovenia (AAPC = −4.6, 95%C.I. = −7.9,−1.3) reported mortality decline in women. These findings inform individuals at increased risk for primary prevention

Radio-Frequency Beam Conditioner for Fast-Wave Free-Electron Generators of Coherent Radiation

A method for conditioning electron beams is proposed, making use of the TM{sub 210} mode of microwave cavities, to reduce the axial velocity spread within the beam, in order to enhance gain in resonant electron beam devices, such as the free-electron laser (FEL). Effectively, a conditioner removes the restriction on beam emittance. The conditioner is analyzed using a simple model for beam transport and ideal RF cavities. Analysis of an FEL is employed to evaluate performance with reduced axial velocity spread. Examples of FELs are presented showing the distinct advantage of conditioning

Comments on Noncommutative ADHM Construction

We extend the method of matrix partition to obtain explicitly the gauge field for noncommutative ADHM construction in some general cases. As an application of this method we apply it to the U(2) 2-instanton and get explicit result for the gauge fields in the coincident instanton limit. We also easily apply it to the noncommutative 't Hooft instantons in the appendix.Comment: 17 pages, LaTeX; an appendix added, typos corrected, refs adde

Modular Cosmology, Thermal Inflation, Baryogenesis and Predictions for Particle Accelerators

Modular cosmology is plagued by overproduction of unwanted relics, gravitinos and especially moduli, at relatively low energy scales. Thermal inflation provides a compelling solution to this moduli problem, but invalidates most baryogenesis scenarios. We propose a simple model in which the MSSM plus neutrino mass term $(LH_u)^2$ is supplemented by a minimal flaton sector to drive the thermal inflation, and make two crucial assumptions: the flaton vacuum expectation value generates the $\mu$-term of the MSSM and $m_L^2 + m_{H_u}^2 < 0$. The second assumption is particularly interesting in that it violates a well known constraint, implying that there exists a nearby deep non-MSSM vacuum, and provides a clear signature of our model which can be tested at future particle accelerators. We show that our model leads to thermal inflation followed by Affleck-Dine leptogenensis along the $LH_u$ flat direction. A key feature of our leptogenesis scenario is that the $H_uH_d$ flat direction is also induced to temporarily acquire a large value, playing a crucial role in the leptogenesis, as well as dynamically shielding the field configuration from the deep non-MSSM minimum, ensuring that the fields relax into our MSSM vacuum.Comment: v3; 19 pages, 3 figures; added a reference for section

Localized states in 2D semiconductors doped with magnetic impurities in quantizing magnetic field

A theory of magnetic impurities in a 2D electron gas quantized by a strong magnetic field is formulated in terms of Friedel-Anderson theory of resonance impurity scattering. It is shown that this scattering results in an appearance of bound Landau states with zero angular moment between the Landau subbands. The resonance scattering is spin selective, and it results in a strong spin polarization of Landau states, as well as in a noticeable magnetic field dependence of the $g$ factor and the crystal field splitting of the impurity $d$ levels.Comment: 12 pages, 4 figures Submitted to Physical Review B This version is edited and updated in accordance with recent experimental dat

Nonlinear superhorizon perturbations of non-canonical scalar field

We develop a theory of non-linear cosmological perturbations at superhorizon scales for a scalar field with a Lagrangian of the form $P(X,\phi)$, where $X=-\partial^{\mu}\phi\partial_{\mu}\phi$ and $\phi$ is the scalar field. We employ the ADM formalism and the spatial gradient expansion approach to obtain general solutions valid up to the second order in the gradient expansion. This formulation can be applied to, for example, DBI inflation models to investigate superhorizon evolution of non-Gaussianities. With slight modification, we also obtain general solutions valid up to the same order for a perfect fluid with a general equation of state $P=P(\rho)$.Comment: 14 page