Investigation of Magnetic Nanoparticles Fe0.6Co0.4@C by NMR Method

Nanoparticles Fe0.6Co0.4@C were synthesized by the gas-phase method, part of the sample was annealed to increase magnetization. NMR spectra of 59Co were obtained. Analysis of the data obtained showed that after annealing, the spectrum corresponds to an ordered alloy with a BCC lattice.Работа выполнена в рамках проекта РНФ № 21-72-0007

ЛЕКАРСТВЕННЫЙ ГЕПАТИТ У ДЕТЕЙ

Among toxic lesions of the liver, an important place belongs to medicinal hepatitis. Among patients with hepatitis, drug disease of the liver occurs in 0.7—1.4% of cases, and in the presence of jaundice — in 5%. A family case of sisters 9 and 4-year-old life development  of acute drug hepatitis caused by ibuprofen in a daily dose of 32 mg / kg (total 3.2 g) and 25 mg / kg (total 2 g), respectively, was demonstrated in siblings. Hepatitis developed after an acute respiratory infection. Weakness, nausea, vomiting, jaundice of the skin and sclera, pruritus, multiple increase in serum transaminases and markers of cholestasis are revealed. Viral hepatitis and some hereditary liver diseases were excluded. The drug lesion of the liver was of a mixed nature: hepatocellular (cytotoxic) and cholestatic. Timely administration of therapy (detoxification, glucocorticosteroids, ursodeoxycholic acid (Ursosan) led to a regression of clinical symptoms of the disease and positive dynamics of laboratory indicators.В группе токсических поражений  печени важное место принадлежит лекарственным гепатитам. Среди пациентов с гепатитом, лекарственная болезнь печени встречается в 0,7—1,4% случаев, а при наличии желтухи  — в 5%. Представленные  данные продемонстрированы описанием семейного случая развития у родных сестер 9,5 и 4,5 лет жизни острого лекарственного гепатита, вызванного ибупрофеном в суточной дозе 32 мг/кг (суммарной 3,2  г) и 25 мг/кг (суммарной 2 г) соответственно. Гепатит развился на фоне реконвалесценции после острой респираторной инфекции. Выявлена слабость, тошнота, рвота, желтушность кожи и склер, кожный зуд, многократное повышение уровня сывороточных трансаминаз и маркеров холестаза. Были исключены вирусные  гепатиты и некоторые наследственные заболевания печени. Лекарственное поражение печени носило смешанный характер: гепатоцеллюлярное (цитотоксическое) и холестатическое. Своевременное назначение терапии (дезинтоксикация, глюкокортикостероиды, урсодезоксихолевая кислота (Урсосан) привело к регрессу клинических симптомов заболевания и положительной динамике лабораторных показателей

INVESTIGATION OF MAGNETIC NANOPARTICLES Fe0.5Co0.5 BY RESONANCE SPECTROSCOPY

Nanoparticles Fe0.5Co0.5 were synthesized by the gas-phase method, part of the sample was annealed. The NMR spectra of 59Co and NGR 57Fe have been obtained, and the magnet-ization and effective surface of the nanoparticles have been measured. The 59Co NMR spectra are inhomogeneously broadened lines.Работа выполнена в рамках государственных тем «Функция» № АААА-А19-119012990095-0, «Магнит» No АААА-А18-118020290129-5 и «Сплавы» № АААА-А19-119070890020-3)

STUDY OF THE INTERNAL STRUCTURE AND MAGNETIC PROPERTIES OF NANOPARTICLES BASED ON FeMe@C (Me=Co,Ni) BINARY ALLOYS BY NMR

FeMe@C (Me=Co,Ni) nanoparticles were synthesized by the gas-phase method, some of them were annealed to increase the magnetization. 59Co, 61Ni and 57Fe NMR spectra were obtained. By annealing, it is possible to obtain a structurally ordered phase of the FeCo alloy in the core of the particles.Работа выполнена в рамках проекта РНФ № 21-72-00007

The CCCTC-Binding Factor (CTCF) of Drosophila Contributes to the Regulation of the Ribosomal DNA and Nucleolar Stability

In the repeat array of ribosomal DNA (rDNA), only about half of the genes are actively transcribed while the others are silenced. In arthropods, transposable elements interrupt a subset of genes, often inactivating transcription of those genes. Little is known about the establishment or separation of juxtaposed active and inactive chromatin domains, or preferential inactivation of transposable element interrupted genes, despite identity in promoter sequences. CTCF is a sequence-specific DNA binding protein which is thought to act as a transcriptional repressor, block enhancer-promoter communication, and delimit juxtaposed domains of active and inactive chromatin; one or more of these activities might contribute to the regulation of this repeated gene cluster. In support of this hypothesis, we show that the Drosophila nucleolus contains CTCF, which is bound to transposable element sequences within the rDNA. Reduction in CTCF gene activity results in nucleolar fragmentation and reduced rDNA silencing, as does disruption of poly-ADP-ribosylation thought to be necessary for CTCF nucleolar localization. Our data establish a role for CTCF as a component necessary for proper control of transposable element-laden rDNA transcription and nucleolar stability