161 research outputs found
AIF Downregulation and Its Interaction with STK3 in Renal Cell Carcinoma
Apoptosis-inducing factor (AIF) plays a crucial role in caspase-independent programmed cell death by triggering chromatin condensation and DNA fragmentation. Therefore, it might be involved in cell homeostasis and tumor development. In this study, we report significant AIF downregulation in the majority of renal cell carcinomas (RCC). In a group of RCC specimens, 84% (43 out of 51) had AIF downregulation by immunohistochemistry stain. Additional 10 kidney tumors, including an oxyphilic adenoma, also had significant AIF downregulation by Northern blot analysis. The mechanisms of the AIF downregulation included both AIF deletion and its promoter methylation. Forced expression of AIF in RCC cell lines induced massive apoptosis. Further analysis revealed that AIF interacted with STK3, a known regulator of apoptosis, and enhanced its phosphorylation at Thr180. These results suggest that AIF downregulation is a common event in kidney tumor development. AIF loss may lead to decreased STK3 activity, defective apoptosis and malignant transformation
Towards diluted magnetism in TaAs
Magnetism in Weyl semimetals is desired to investigate the interaction
between the magnetic moments and Weyl fermions, e.g. to explore anomalous
quantum Hall phenomena. Here we demonstrate that proton irradiation is an
effective tool to induce ferromagnetism in the Weyl semimetal TaAs. The
intrinsic magnetism is observed with a transition temperature above room
temperature. The magnetic moments from d states are found to be localized
around Ta atoms. Further, the first-principles calculations indicate that the d
states localized on the nearest-neighbor Ta atoms of As vacancy sites are
responsible for the observed magnetic moments and the long-ranged magnetic
order. The results show the feasibility of inducing ferromagnetism in Weyl
semimetals so that they may facilitate the applications of this material in
spintronics.Comment: 20 pages, 6 figure
Unusual double-peak specific heat and spin freezing in a spin-2 triangular lattice antiferromagnet FeAlSe
We report the properties of a triangular lattice iron-chalcogenide
antiferromagnet FeAlSe. The spin susceptibility reveals a
significant antiferromagnetic interaction with a Curie-Weiss temperature
{\Theta} ~ -200K and a spin-2 local moment. Despite a large spin and a
large |{\Theta}|, the low-temperature behaviors are incompatible with
conventional classical magnets. No long-range order is detected down to 0.4K.
Similar to the well-known spin-1 magnet NiGaS, the specific heat of
FeAlSe exhibits an unusual double-peak structure and a T
power law at low temperatures, which are attributed to the underlying
quadrupolar spin correlations and the Halperin-Saslow modes, respectively. The
spin freezing occurs at ~ 14K, below which the relaxation dynamics is probed by
the ac susceptibility. Our results are consistent with the early theory for the
spin-1 system with Heisenberg and biquadratic spin interactions. We argue that
the early proposal of the quadrupolar correlation and gauge glass dynamics may
be well extended to FeAlSe. Our results provide useful insights
about the magnetic properties of frustrated quantum magnets with high spins.Comment: 7 pages, 4 figure
Controllable Growth of Vertically Aligned Graphene on C-face SiC
We investigated how to control the growth of vertically aligned graphene on C-face SiC by varying the processing conditions. It is found that, the growth rate scales with the annealing temperature and the graphene height is proportional to the annealing time. Temperature gradient and crystalline quality of the SiC substrates influence their vaporization. The partial vapor pressure is crucial as it can interfere with further vaporization. A growth mechanism is proposed in terms of physical vapor transport. The monolayer character of vertically aligned graphene is verified by Raman and X-ray absorption spectroscopy. With the processed samples, d0 magnetism is realized and negative magnetoresistance is observed after Cu implantation. We also prove that multiple carriers exist in vertically aligned graphene
Mid- and far-infrared localized surface plasmon resonances in chalcogen-hyperdoped silicon
Plasmonic sensing in the infrared region employs the direct interaction of
the vibrational fingerprints of molecules with the plasmonic resonances,
creating surface-enhanced sensing platforms that are superior than the
traditional spectroscopy. However, the standard noble metals used for plasmonic
resonances suffer from high radiative losses as well as fabrication challenges,
such as tuning the spectral resonance positions into mid- to far-infrared
regions, and the compatibility issue with the existing complementary
metal-oxide-semiconductor (CMOS) manufacturing platform. Here, we demonstrate
the occurrence of mid-infrared localized surface plasmon resonances (LSPR) in
thin Si films hyperdoped with the known deep-level impurity tellurium. We show
that the mid-infrared LSPR can be further enhanced and spectrally extended to
the far-infrared range by fabricating two-dimensional arrays of
micrometer-sized antennas in a Te-hyperdoped Si chip. Since Te-hyperdoped Si
can also work as an infrared photodetector, we believe that our results will
unlock the route toward the direct integration of plasmonic sensors with the
one-chip CMOS platform, greatly advancing the possibility of mass manufacturing
of high-performance plasmonic sensing systems.Comment: 20 pages, 5 figure
Mixed Eucalyptus plantations in subtropical China enhance phosphorus accumulation and transformation in soil aggregates
IntroductionThe production of Eucalyptus, a principal economic tree genus in China, is faced with challenges related to soil phosphorus (P) limitations. In this study, we explore variations in phosphorus content, storage, and transformation in Eucalyptus forests. We hypothesize that mixed forests augment soil aggregate stability and P content and that microaggregates are pivotal in determining P differences between mixed and pure forests. Additionally, we posit that mixed forests foster P transformation, enhancing its efficacy in the soil. Current research on the distribution and transformation of soil total P (TP) and P fractions at the soil aggregate level is limited.MethodsIn this study, we selected soil from a Eucalyptus-Mytilaria laosensis Lecomte mixed forest, Eucalyptus-Erythrophleum fordii Oliv mixed forest, and pure Eucalyptus forest in Chongzuo County, Guangxi, China, as the research objects. Using a dry-sieving method, we divided the soil collected in situ from the 0–40 cm layer into aggregates of >2, 1–2, 0.25–1, and <0.25 mm particle sizes, measured the TP and P fractions (resin-extractable inorganic P, bicarbonate-extractable inorganic P, bicarbonate-extractable organic P, sodium hydroxide-extractable inorganic P, sodium hydroxide-extractable organic P, dilute hydrochloric acid-extractable P, concentrated hydrochloric acid extractable inorganic P, concentrated hydrochloric acid-extractable organic P and residue-P) in different aggregates, and used redundancy analysis and PLS SEM to reveal key factors affecting soil P accumulation and transformation.ResultsThe results showed that compared to pure Eucalyptus forests, mixed Eucalyptus forests significantly enhanced the stability of soil aggregates and the content and storage of phosphorus, especially the Eucalyptus-Mytilaria laosensis mixed forest. The content of total soil phosphorus and its fractions decreased with increasing aggregate particle size, while the opposite trend was observed for stored P, with aggregates <0.25 mm being the main fraction influencing soil phosphorus accumulation. The transformation process of P fractions was primarily constrained by dissolution rates, mineralization rates, biological activity, including the action of microbes, fungi, and plant–root interactions, and other factors.DiscussionMixed forests increased the transformation of phosphorus in soil aggregates, effectivel enhancing the availability of soil phosphorus. In summary, this study provides important evidence for the systematic management of subtropical artificia Eucalyptus forests and the sustainable utilization of soil resources
- …