THE STUDY AND MANUFACTURE OF 10 METERS LARGE-SCALE SIMULATED TRAINING TREADMILL

INTRODUCTION: In order to take a simulated training, make a scientific monitor and make technical diagnoses of biomechanics for the elite middle and long distance runners and walkers , we has developed a 10 meters large-scale treadmill all by itself. METHODS OF MANUFACTURE: 1. The mechanical component adopts frame structure, rolling rub, shaft drive and synthetic surface track. 2. The electrical component adopts speed controller of changing the frequency, computerized programming and manual two-way control. REQUIREMENT OF THE FUNCTION: 1. The track is 1m in width and 10m in length and can hold 4 sportsmen running on it simultaneously. 2. The track speed is controlled by computerized program. The max. speed is 12m/s.Scope of stable speed: 0.7-1.3/ms, infinitely variable speeds, a stable variation of the speed. Accelerated function: 1.2m/s2. 3. The noise i

Studies on the protective effect of total flavonoids from Cichorium glandulosum roots against carbon tetrachloride-induced liver fibrosis in rats

Purpose: To study the protective influence of total flavonoids from Cichorium glandulosum roots (TFCG) against carbon tetrachloride-mediated hepatic fibrosis in rats, and the probable mechanism of action involved.Methods: Rats with liver fibrosis were orally administered TFCG (50, 100 or 200 mg/kg) once a day for 13 weeks. Liver index and liver injury indices in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AKP), lactate dehydrogenase (LDH), γ-glutamyl transpeptidase (γ-GT), hydroxyproline (HYP), albumin (ALB) and malondialdehyde (MDA) were determined using electronic balance or corresponding assay kits, as appropriate. Following staining with hematoxylin and eosin and Van Gieson, histopathological changes in liver tissues were examined by light microscopy. TGF-β/Smad pathway-related protein expressions in liver tissues, viz, transforming growth factor-β1 (TGF-β1), mothers against decapentaplegic homolog 3 (Smad3), Smad7, toll-like receptor 4 (TLR4) and α-smooth muscle actin (α-SMA) were determined using immunohistochemical techniques.Results: Exposure to TFCG significantly reversed abnormal serum levels of ALT, AST, AKP, LDH, γ- GT, HYP, ALB and MDA rats with liver fibrosis to normal levels, and also decreased their liver index values (p < 0.01). Moreover, TFCG improved histopathological changes in the liver tissues of fibrotic rats, and significantly reversed abnormal TGF-β1, Smad3, Smad7, TLR4 and α-SMA protein expressions in the liver tissues of fibrotic rats to normal levels (p < 0.05 or 0.01).Conclusion: These results indicate that TFCG exerts protective effect against liver fibrosis via a mechanism related to inactivation of TGF-β/Smad pathway. Thus, TFCG may find application in liver fibrosis therapy.Keywords: Cichorium glandulosum, Flavonoids, Liver, Fibrosis, TGF-β/Smad pathwa

Nonlinear Current Control for Reluctance Actuator with Hysteresis Compensation

The next-generation fine stage of the wafer scanner needs a suitable actuator to meet the requirements of high speed, high acceleration, and high precision. The voice coil actuator is no longer the best choice because of its large size and the heat dissipation is difficult to solve. The reluctance actuator can provide a big force based on a unique property of small volume and low current, making it a very suitable candidate. But the strong nonlinearity such as the hysteresis between the current and force limits the reluctance actuator applications in nanometer positioning. This paper proposes a nonlinear current control configuration with hysteresis compensation using the adaptive multilayer neural network. Simulation results show that the hysteresis compensator is effective in overcoming the hysteresis and is promising in precision control applications

GEOGLE: context mining tool for the correlation between gene expression and the phenotypic distinction

<p>Abstract</p> <p>Background</p> <p>In the post-genomic era, the development of high-throughput gene expression detection technology provides huge amounts of experimental data, which challenges the traditional pipelines for data processing and analyzing in scientific researches.</p> <p>Results</p> <p>In our work, we integrated gene expression information from Gene Expression Omnibus (GEO), biomedical ontology from Medical Subject Headings (MeSH) and signaling pathway knowledge from sigPathway entries to develop a context mining tool for gene expression analysis – GEOGLE. GEOGLE offers a rapid and convenient way for searching relevant experimental datasets, pathways and biological terms according to multiple types of queries: including biomedical vocabularies, GDS IDs, gene IDs, pathway names and signature list. Moreover, GEOGLE summarizes the signature genes from a subset of GDSes and estimates the correlation between gene expression and the phenotypic distinction with an integrated p value.</p> <p>Conclusion</p> <p>This approach performing global searching of expression data may expand the traditional way of collecting heterogeneous gene expression experiment data. GEOGLE is a novel tool that provides researchers a quantitative way to understand the correlation between gene expression and phenotypic distinction through meta-analysis of gene expression datasets from different experiments, as well as the biological meaning behind. The web site and user guide of GEOGLE are available at: <url>http://omics.biosino.org:14000/kweb/workflow.jsp?id=00020</url></p

DEVELOPMENT AND APPLICATION OF A SIMULATED ALTITUDE CABIN

The purpose of this study was to examine the techniques of simulated altitude cabin developed by the Shandong Sports Science Center, China. Blood lactate of two male and two female long distance taking the contrast test of the same exercise load of Monark 829 bicycle and treadmill both in and out of the cabin was measured. Hemoglobin of four elite walk runners who lived in the cabin with the altitude of 3,000m for 14 hours every day and took the training out of the cabin in the rest of the time was also measured. Results showed that the value of blood lactate for same athlete after exercise load in the cabin is obviously higher than those outside of cabin, and that the mean value of hemoglobin of the four elite athletes increased 1.3g/dl before and after the test. It is concluded that the manufacture of the simulated altitude cabin is successful in simulating actual altitude training