The Role of Carbonate Factories and Sea Water Chemistry on Basin-Wide Ramp to High-Relief Carbonate Platform Evolution: Triassic, Nanpanjiang Basin, South China

The end-Permian extinction and its aftermath altered carbonate factories globally for millions of years, but its impact on platform geometries remains poorly understood. Here, the evolution in architecture and composition of two exceptionally exposed platforms in the Nanpanjiang Basin are constrained and compared with geochemical proxies to evaluate controls on platform geometries. Geochemical proxies indicate elevated siliciclastic and nutrient fluxes in the basal Triassic, at the Induan—Olenekian boundary and in the uppermost Olenekian. Cerium/Ce* shifts from high Ce/Ce* values and a lack of Ce anomaly indicating anoxia during the Lower Triassic to a negative Ce anomaly indicating oxygenation in the latest Olenekian and Anisian. Uranium and Mo depletion represents widespread anoxia in the world\u27s oceans in the Early Triassic with progressive oxygenation in the Anisian. Carbonate factories shifted from skeletal in the Late Permian to abiotic and microbial in the Early Triassic before returning to skeletal systems in the Middle Triassic, Anisian coincident with declining anoxia. Margin facies shifted to oolitic grainstone in the Early Triassic with development of giant ooids and extensive marine cements. Anisian margins, in contrast, are boundstone with a diverse skeletal component. The shift in platform architecture from ramp to steep, high-relief, flat-topped profiles is decoupled from carbonate compositions having occurred in the Olenekian prior to the onset of basin oxygenation and biotic stabilisation of the margins. A basin-wide synchronous shift from ramp to high-relief platforms points to a combination of high subsidence rate and basin starvation coupled with high rates of abiotic and microbial carbonate accumulation and marine cement stabilisation of oolitic margins as the primary causes for margin up-building. High sea water carbonate saturation resulting from a lack of skeletal sinks for precipitation, and basin anoxia promoting an expanded depth of carbonate supersaturation, probably contributed to marine cement stabilisation of margins that stimulated the shift from ramp to high-relief platform architecture

Research Progress on the Formation of and Control Methods for Harmful Products from Maillard Reaction in Brown Sugar Production

The Maillard reaction during the production of brown sugar is critical to the color, flavor and functional characteristics of brown sugar, but it also produces substances potentially harmful to human health such as glyoxal (GO), methylglyoxal (MGO), 3-deoxyglucosone (3-DG), 5-hydroxymethylfurfural (5-HMF), and acrylamide. This paper introduces the Maillard reaction at the key stages of the brown sugar production process, its influential factors, its possible harmful products and their effects on human health, and it puts forward some suggestions for controlling the production of harmful products from Maillard reaction during brown sugar production in order to provide a theoretical reference for improving the safety of brown sugar for consumption

A multifactorial analysis of FAP to regulate gastrointestinal cancers progression

BackgroundFibroblast activation protein (FAP) is a cell-surface serine protease that has both dipeptidyl peptidase as well as endopeptidase activities and could cleave substrates at post-proline bond. Previous findings showed that FAP was hard to be detected in normal tissues but significantly up-regulated in remodeling sites like fibrosis, atherosclerosis, arthritis and embryonic tissues. Though increasing evidence has demonstrated the importance of FAP in cancer progression, no multifactorial analysis has been developed to investigate its function in gastrointestinal cancers until now.MethodsBy comprehensive use of datasets from The Cancer Genome Atlas (TCGA), Clinical Proteomic Tumor Analysis Consortium (CPTAC), scTIME Portal and Human Protein Atlas (HPA), we evaluated the carcinogenesis potential of FAP in gastrointestinal cancers, analyzing the correlation between FAP and poor outcomes, immunology in liver, colon, pancreas as well as stomach cancers. Then liver cancer was selected as example to experimentally validate the pro-tumor and immune regulative role of FAP in gastrointestinal cancers.ResultsFAP was abundantly expressed in gastrointestinal cancers, such as LIHC, COAD, PAAD and STAD. Functional analysis indicated that the highly-expressed FAP in these cancers could affect extracellular matrix organization process and interacted with genes like COL1A1, COL1A2, COL3A1 and POSTN. In addition, it was also observed that FAP was positively correlated to M2 macrophages infiltration across these cancers. To verify these findings in vitro, we used LIHC as example and over-expressed FAP in human hepatic stellate LX2 cells, a main cell type that produce FAP in tumor tissues, and then investigate its role on LIHC cells as well as macrophages. Results showed that the medium from FAP-over-expressed LX2 cells could significantly promote the motility of MHCC97H and SK-Hep1 LIHC cells, increase the invasion of THP-1 macrophages and induce them into pro-tumor M2 phenotype.ConclusionIn summary, we employed bioinformatic tools and experiments to perform a comprehensive analysis about FAP. Up-regulation of FAP in gastrointestinal cancers was primarily expressed in fibroblasts and contributes to tumor cells motility, macrophages infiltration and M2 polarization, revealing the multifactorial role of FAP in gastrointestinal cancers progression

Molecular dynamics simulations of structural transformation of perfluorooctane sulfonate (PFOS) at water/rutile interfaces

Concentration and salinity conditions are the dominant environmental factors affecting the behavior of perfluorinated compounds (PFCs) on the surfaces of a variety of solid matrices (suspended particles, sediments, and natural minerals). However, the mechanism has not yet been examined at molecular scales. Here, the structural transformation of perfluorooctane sulfonate (PFOS) at water/rutile interfaces induced by changes of the concentration level of PFOS and salt condition was investigated using molecular dynamics (MD) simulations. At low and intermediate concentrations all PFOS molecules directly interacted with the rutile (110) surface mainly by the sulfonate headgroups through electrostatic attraction, yielding a typical monolayer structure. As the concentration of PFOS increased, the molecules aggregated in a complex multi-layered structure, where an irregular assembling configuration was adsorbed on the monolayer structure by the van der Waals interactions between the perfluoroalkyl chains. When adding CaCl2 to the system, the multi-layered structure changed to a monolayer again, indicating that the addition of CaCl2 enhanced the critical concentration value to yield PFOS multilayer assemblies. The divalent Ca2+ substituted for monovalent K+ as the bridging counterion in PFOS adsorption. MD simulation may trigger wide applications in study of perfluorinated compounds (PFCs) from atomic/molecular scale

Lyapunov-Based Large Signal Stability Assessment for VSG Controlled Inverter-Interfaced Distributed Generators

Inverter-interfaced distributed generators (IIDGs) have been widely applied due to their control flexibility. The stability problems of IIDGs under large signal disturbances, such as large load variations and feeder faults, will cause serious impacts on the system. The virtual synchronous generator (VSG) control is an effective scheme for IIDGs to increase transient stability. However, the existing linearized stability models of IIDGs are limited to small disturbances. Hence, this paper proposes a Lyapunov approach based on non-linearized models to assess the large signal stability of VSG-IIDG. The electrostatic machine model is introduced to establish the equivalent nonlinear model. On the basis of Popov’s theory, a Lyapunov function is derived to calculate the transient stability domain. The stability mechanism is revealed by depicting the stability domain using the locus of the angle and the angular frequency. Large signal stability of the VSG-IIDG is quantified according to the boundary of the stability domain. Effects and sensitivity analysis of the key parameters including the cable impedance, the load power, and the virtual inertia on the stability of the VSG-IIDG are also presented. The simulations are performed in PSCAD/EMTDC and the results demonstrate the proposed large signal stability assessment method

Characteristics of marine communities in the aftermath of the latest Permian mass extinction, Bank of Guizhou, South China

The aftermath of the late Permian mass extinction is a key interval for the evolution of modern marine ecosystems. It has been hypothesized that the magnitude of the mass extinction delayed the subsequent recovery, and so to test this, we undertook the highest resolution study to date of the post-extinction (Griesbachian) microbialite unit on the Great Bank of Guizhou, South China. The benthic community from the microbialite unit is taxonomically diverse when compared to other coeval deposits, recording both inarticulate and articulate brachiopods, crinoids, echinoids, bivalves, gastropods, microconchids, and ostracods. Here we recognize 49 taxa from 4557 individuals, which raise the known diversity of the Great Bank of Guizhou basal microbialite unit to 84 invertebrate species, making it the most diverse Early Triassic community currently reported. 89% of the genera are Permian holdovers, whilst only 13% of the species are Permian holdovers. This new data record no temporal trends in the species richness, Simpson diversity, Simpson effective diversity, taxonomic distinctness, functional diversity, or body size of the benthos during the post-extinction microbialite unit. Nevertheless, the small body sizes of the benthic community, and the large lophophoral cavity in the lingulid brachiopod, Sinolingularia huananensis, suggests that these animals lived in a highly stressed environment. We propose that the microbialite unit contains a survival fauna in an interval that represents persistent environmental stress from the late Permian mass extinction event, associated with deoxygenation, high temperatures, elevated atmospheric carbon dioxide levels (pCO2), and elevated primary productivity