15,934 research outputs found
Design., analysis and experiment planning of one-story reinforced concrete frame-wall-diaphragm assemblage, July 1989
Cyclic tests of components of one-story reinforced concrete framewall-diaphragm assemblage, December 1989
Multi-chromatic narrow-energy-spread electron bunches from laser wakefield acceleration with dual-color lasers
A method based on laser wakefield acceleration with controlled ionization
injection triggered by another frequency-tripled laser is proposed, which can
produce electron bunches with low energy spread. As two color pulses
co-propagate in the background plasma, the peak amplitude of the combined laser
field is modulated in time and space during the laser propagation due to the
plasma dispersion. Ionization injection occurs when the peak amplitude exceeds
certain threshold. The threshold is exceeded for limited duration periodically
at different propagation distances, leading to multiple ionization injections
and separated electron bunches. The method is demonstrated through
multi-dimensional particle-in-cell simulations. Such electron bunches may be
used to generate multi-chromatic X-ray sources for a variety of applications.Comment: 5 pages, 5 figures; accepted by PR
Ruthenium-based antitumor drugs and delivery systems from monotherapy to combination therapy
Ruthenium complex is an important compound group for antitumor drug research and development. NAMI-A, KP1019, TLD1433 and other ruthenium complexes have entered clinical research. In recent years, the research on ruthenium antitumor drugs has not been limited to single chemotherapy drugs; other applications of ruthenium complexes have emerged such as in combination therapy. During the development of ruthenium complexes, drug delivery forms of ruthenium antitumor drugs have also evolved from single-molecule drugs to nanodrug delivery systems. The review summarizes the following aspects: (1) ruthenium complexes from monotherapy to combination therapy, including the development of single-molecule compounds, carrier nanomedicine, and self-assembly of carrier-free nanomedicine; (2) ruthenium complexes in the process of ADME in terms of absorption, distribution, metabolism and excretion; (3) the applications of ruthenium complexes in combination therapy, including photodynamic therapy (PDT), photothermal therapy (PTT), photoactivated chemotherapy (PACT), immunotherapy, and their combined application; (4) the future prospects of ruthenium-based antitumor drugs.publishedVersio
Continuous-Time Graph Learning for Cascade Popularity Prediction
Information propagation on social networks could be modeled as cascades, and
many efforts have been made to predict the future popularity of cascades.
However, most of the existing research treats a cascade as an individual
sequence. Actually, the cascades might be correlated with each other due to the
shared users or similar topics. Moreover, the preferences of users and
semantics of a cascade are usually continuously evolving over time. In this
paper, we propose a continuous-time graph learning method for cascade
popularity prediction, which first connects different cascades via a universal
sequence of user-cascade and user-user interactions and then chronologically
learns on the sequence by maintaining the dynamic states of users and cascades.
Specifically, for each interaction, we present an evolution learning module to
continuously update the dynamic states of the related users and cascade based
on their currently encoded messages and previous dynamic states. We also devise
a cascade representation learning component to embed the temporal information
and structural information carried by the cascade. Experiments on real-world
datasets demonstrate the superiority and rationality of our approach.Comment: 9 pages, 5 figures, IJCAI 202
An NMR Study on Hydration and Molecular Interaction of PhytantriolâBased Liquid Crystals
Phytantriol-based lyotropic liquid crystals (LLCs) have emerged as a new nanodrug delivery system. However, the understanding of phytantriol-based LLCs is lacking. In this study, we use NMR technology to characterize LLC formation over two months. Three samples in different phases were prepared with different hydration states. NMR data, including 1D-1H, 13C-{1H}, 2D-HSQC, HMBC, COSY, NOESY, etc., were collected. A comprehensive analysis of these NMR data was performed on the three phases of phytantriol-based LLCs. The following results were achieved from the study. First, the 1H and 13C-{1H} spectra of phytantriol were assigned. Second, the change of NMR spectra during the formation of the phases was observed, and the change of hydration was calculated for the time-dependent phase formation. Third, the correlation peaks of 2D-NOESY were used to describe the spatial relationship of lipidsâwater interaction and lipidâlipid interaction.publishedVersio
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