Research Advance on the Relationship between Wee1 and Tumor Genesis and Progression

In the process of biological genetic information transmission, complete and correct genetic information can make cell mitosis proceed normally.In the development of most tumor cells, G2/M cell cycle checkpoint becomes the key checkpoint in the process of mitosis due to the lack of G1/S cell cycle checkpoint, which mainly depends on the abnormal DNA information blocked by Wee1 protein kinase in G2 phase to enter M phase and prolong the time of G2 phase to complete DNA sequencing So that the normal genetic information can be passed on. Wee1 protein kinase expression is significantly increased in most tumor cells,making it a potential target for tumor therapy

A pathway analysis of genome-wide association study highlights novel type 2 diabetes risk pathways.

Genome-wide association studies (GWAS) have been widely used to identify common type 2 diabetes (T2D) variants. However, the known variants just explain less than 20% of the overall estimated genetic contribution to T2D. Pathway-based methods have been applied into T2D GWAS datasets to investigate the biological mechanisms and reported some novel T2D risk pathways. However, few pathways were shared in these studies. Here, we performed a pathway analysis using the summary results from a large-scale meta-analysis of T2D GWAS to investigate more genetic signals in T2D. Here, we selected PLNK and VEGAS to perform the gene-based test and WebGestalt to perform the pathway-based test. We identified 8 shared KEGG pathways after correction for multiple tests in both methods. We confirm previous findings, and highlight some new T2D risk pathways. We believe that our results may be helpful to study the genetic mechanisms of T2D

How to Build Practice Teaching System of Financial Mathematics in Local Universities

In this paper, the writer combined the experience in financial mathematics direction teaching with the results of the survey of tracking graduates, and analyzed the necessity for local colleges to carry out practical teaching in financial mathematics teaching. What’s more, the writer also proposes some suggestion in establishing practical teaching system of financial mathematics.Key words: Financial mathematics; Practical teaching; Teaching mod

A Fuzzy LP Approach to Option Portfolio

Abstract: Owing to the fluctuation of financial market from time to time,the volatility and stock price may occur imprecisely in the real world. Therefore, it is natural to consider the fuzzy volatility and fuzzy stock price in the financial market. Under these assumptions,the theoretical price deduced by Black–Scholes formula are will turn into the fuzzy numbers, and the derivatives, called the Greek parameters delta, gamma, of the BS model are also fuzzy numbers. An option portfolio considering these fuzzy numbers will be more accord with actual situations. In this paper, we propose a fuzzy programming model of option portfolio based a ranking criterion of fuzzy numbers, which the fuzzy option portfolio model is converted into a classical linear programming problem. Finally, a numerical example is given to illustrate the validity of the method. Key words: Ranking Criterion; Option portfolio; Fuzzy Linear Programming; Delta-Gamma Neutra

Pricing European Call Currency option based on Adaptive Fuzzy Numbers with Possibilistic Mean

In this paper we use the fuzzy estimators based on confidence intervals in order to estimate the volatility of currency exchange rate having sample data. We model the uncertainty of the characteristics such as interest rates and volatility using adaptive fuzzy numbers and replace the fuzzy currency option price and the fuzzy volatility by the possibilistic mean value. Furthermore, a numerical example is presented, and we get the expected prices which depend on given degree of confidence. Key words: Currency Option; Option Pricing; Possibilistic Mean Value; Fuzzy Volatility; G-K Mode

The Discussion on the Mode of Undergraduate Tutorial System for Financial Mathematics Students of Local Universities

With the decreasing in the number of college students, the students quality of local university is also decreasing. This paper proposes the mode of tutor system for financial mathematics students of local universities. And it is analysis the necessity and the importance of tutor system for teaching, employment, etc. we also propose some suggestions on how to execute tutor system

Two NHX-type transporters from Helianthus tuberosus improve the tolerance of rice to salinity and nutrient deficiency stress.

The NHX-type cation/H+ transporters in plants have been shown to mediate Na+ (K+ )/H+ exchange for salinity tolerance and K+ homoeostasis. In this study, we identified and characterized two NHX homologues, HtNHX1 and HtNHX2 from an infertile and salinity tolerant species Helianthus tuberosus (cv. Nanyu No. 1). HtNHX1 and HtNHX2 share identical 5'- and 3'-UTR and coding regions, except for a 342-bp segment encoding 114 amino acids (L272 to Q385 ) which is absent in HtNHX2. Both hydroponics and soil culture experiments showed that the expression of HtNHX1 or HtNHX2 improved the rice tolerance to salinity. Expression of HtNHX2, but not HtNHX1, increased rice grain yield, harvest index, total nutrient uptake under K+ -limited salt-stress or general nutrient deficiency conditions. The results provide a novel insight into NHX function in plant mineral nutrition