Addressing Role Transitions in Young and Middle-Aged Adults Post-Stroke in the Inpatient Rehabilitation Setting: An In-Service for Occupational Therapists

Young and middle-aged adults experience disruptions to their daily life roles and responsibilities due to the variety of impairments they may face following a stroke. This population is in the time of their lives where they have a variety of roles and responsibilities that are important to them such as work, parenting, home management, education, driving, community re-integration, and social participation (Harris & Bettger, 2018; Lawrence, 2010, Maaijwee et al., 2015). An extensive literature review was conducted to determine if and when occupational therapists address roles during the rehabilitation process with young and middle-aged adults post-stroke. The thorough review of literature verified that there is a lack of emphasis placed on addressing prior life roles with this population. The literature review indicated that there is a need to educate occupational therapists on the importance of addressing returning to prior life roles during the rehabilitation process with young and middle-aged adults post-stroke. Although occupational therapists have the skills to address meaningful life roles in young and middle-aged adults post-stroke, there is a disconnect between the literature and what is happening in practice in regards to addressing roles prior to discharge. A common theme that was found among the literature was that young and middle-aged adults post-stroke find transitions following discharge to be extremely difficult as they are ill-prepared to successfully return to their prior life roles and responsibilities (Anderson & Whitfield, 2012; Burton, 2000; Cott, Wiles, & Devitt, 2007; Lawrence, 2010; Meijering, Nanninga, & Lettinga, 2015). Involving the client in the recovery process by collaborating to address one\u27s roles in conjunction with other necessary rehabilitation earlier on in treatment can be beneficial in reaching both the goals of the client and the occupational therapist (Lloyd, Roberts, Freeman, 2013; Schiavi et al., 2018; Van der Kemp et al., 2017). The findings of the literature review provide support for the development of a product that aims to inform occupational therapists in the inpatient rehabilitation setting about the importance of addressing return to roles in young and middle-aged adults poststroke, as well as to provide guidance for how to incorporate roles into the treatment process. The overall goal of “Addressing Role Transitions in Young and Middle-Aged Adults Post-Stroke in the Inpatient Rehabilitation Setting: An In-Service for Occupational Therapists” is to enhance role transitions following discharge

A Life History: Sarah Nielsen, PhD, OTR/L

This life history is one of 29 life history interviews which are a part of a larger project, Life Histories of Individuals Who Have Been Influential in Developing Occupational Therapy (OT) in North Dakota and Wyoming. The purpose of the project is to gather information about the history and evolution of OT practice in North Dakota and Wyoming through life histories of individuals who have been influential in developing OT in these two states. It is anticipated that the life history process will be a powerful way to gather this information. This study is intended to provide current and future generations of occupational therapists a view of the history and how OT practice has evolved from its inception to current practice in North Dakota and Wyoming.https://commons.und.edu/ot-oral-histories-posters/1023/thumbnail.jp

Mellom Butler og Bourdieu: En undersøkelse av hvordan språk påvirker kjønn

Jeg hevder at det er nyttig å lese Judith Butler og Pierre Bourdieu sammen for å forstå hvordan språk påvirker kjønn. Jeg argumenterer for dette ved å fokusere spesifikt på hvordan Bourdieu sitt konsept av habitus kan nyansere og klargjøre Butler sitt konsept av performitet. Grunnen til dette er at det er en vanlig feiltolkning av Butler sin teori om kjønnsperformitet at den kun er lingvistisk og voluntaristisk. Habitus, derimot, jorder den i det materielle og understreker kroppen i sentrum av lingvisitikken. Jeg argumenterer for dette gjennom en samlesning av Butler og Bourdieu der jeg poengterer deres motsetninger og tilknytningspunkter. Jeg går deretter over kritikken mot dem, både fra deres lesere og mellom hverandre. Jeg konkluderer med at deres teorier i kombinasjon forklarer best hvordan språk påvirker kjønn, til tross for vanskeligheten ved å føre dem sammen. Denne oppgaven sin kontekst er en feministisk lesning av Bourdieu; en innsats som blir gjort i både sosiologien og filosofien.Filosofi mastergradsoppgaveFILO350MAHF-FIL

'Kristin' Sweet Cherry

Kristin' is a new, mid-season, productive, large, black, high quality sweet cherry. It is similar to 'Schmidt' but trees are more winter hardy and more heavily cropping and fruits are larger. It has performed especially well in tests in Norway, Montana, and New York

"Just an addict"

Bachelor sykepleie, 2016Tittel: ”Bare en narkoman”, ”Just an addict”. Problemstilling: ”Hvordan ivaretar sykepleiere opioidavhengige pasienter med behov for smertebehandling på somatisk sykehus?”. Kort beskrivelse av oppgaven: Oppgaven tar for seg utfordringer knyttet til smertebehandling av opioidavhengige pasienter. Vi har fokusert på sykepleierens holdninger til og kunnskap om denne pasientgruppen. Videre har vi sett viktigheten av kommunikasjon, relasjonsbygging og tillitsforhold som vi mener er vesentlig for å ivareta behovet for smertebehandling til opioidavhengige pasienter når de innlagt på somatisk sykehus. Hensikt: Å øke egen og sykepleieres kunnskap rundt temaet smertebehandling til opioidavhengige pasienter. Metode: I oppgaven har vi benyttet oss av relevant pensum- og selvvalgt faglitteratur, forskning og egne erfaringer fra praksis. Vi har anvendt deler av Joyce Travelbees interaksjonsteori da vi ønsket å belyse det mellommenneskelige aspektet i vår litteraturstudie. Konklusjon: For at sykepleiere skal kunne ivareta opioidavhengige pasienter og for at disse pasientene skal føle seg ivaretatt mener vi at sykepleiere bør bli mer bevisst på egne holdninger, oppdatering av kunnskap og å se pasienten som et unikt individ. I tillegg bør det bli større fokus på omsorg til rusavhengige pasienter samt smertekartlegging og smertebehandling i sykepleierutdanningen. Dette mener vi vil gi gode forutsetninger for smertebehandling til opioidavhengige pasienter i fremtiden

Oncolytic H-1 Parvovirus Hijacks Galectin-1 to Enter Cancer Cells

Clinical studies in glioblastoma and pancreatic carcinoma patients strongly support the further development of H-1 protoparvovirus (H-1PV)-based anticancer therapies. The identification of cellular factors involved in the H-1PV life cycle may provide the knowledge to improve H-1PV anticancer potential. Recently, we showed that sialylated laminins mediate H-1PV attachment at the cell membrane. In this study, we revealed that H-1PV also interacts at the cell surface with galectin-1 and uses this glycoprotein to enter cancer cells. Indeed, knockdown/out of LGALS1, the gene encoding galectin-1, strongly decreases the ability of H-1PV to infect and kill cancer cells. This ability is rescued by the re-introduction of LGALS1 into cancer cells. Pre-treatment with lactose, which is able to bind to galectins and modulate their cellular functions, decreased H-1PV infectivity in a dose dependent manner. In silico analysis reveals that LGALS1 is overexpressed in various tumours including glioblastoma and pancreatic carcinoma. We show by immunohistochemistry analysis of 122 glioblastoma biopsies that galectin-1 protein levels vary between tumours, with levels in recurrent glioblastoma higher than those in primary tumours or normal tissues. We also find a direct correlation between LGALS1 transcript levels and H-1PV oncolytic activity in 53 cancer cell lines from different tumour origins. Strikingly, the addition of purified galectin-1 sensitises poorly susceptible GBM cell lines to H-1PV killing activity by rescuing cell entry. Together, these findings demonstrate that galectin-1 is a crucial determinant of the H-1PV life cycle.publishedVersio

Inhibition of extracellular vesicle-derived miR-146a-5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes

Melanoma has the highest propensity of all cancers to metastasize to the brain with a large percentage of late-stage patients developing metastases in the central nervous system (CNS). It is well known that metastasis establishment, cell survival, and progression are affected by tumour-host cell interactions where changes in the host cellular compartments likely play an important role. In this context, miRNAs transferred by tumour derived extracellular vesicles (EVs) have previously been shown to create a favourable tumour microenvironment. Here, we show that miR-146a-5p is highly expressed in human melanoma brain metastasis (MBM) EVs, both in MBM cell lines as well as in biopsies, thereby modulating the brain metastatic niche. Mechanistically, miR-146a-5p was transferred to astrocytes via EV delivery and inhibited NUMB in the Notch signalling pathway. This resulted in activation of tumour-promoting cytokines (IL-6, IL-8, MCP-1 and CXCL1). Brain metastases were significantly reduced following miR-146a-5p knockdown. Corroborating these findings, miR-146a-5p inhibition led to a reduction of IL-6, IL-8, MCP-1 and CXCL1 in astrocytes. Following molecular docking analysis, deserpidine was identified as a functional miR-146a-5p inhibitor, both in vitro and in vivo. Our results highlight the pro-metastatic function of miR-146a-5p in EVs and identifies deserpidine for targeted adjuvant treatment.publishedVersio

TGF-β promotes microtube formation in glioblastoma through Thrombospondin 1

International audienceAbstract Background Microtubes (MTs), cytoplasmic extensions of glioma cells, are important cell communication structures promoting invasion and treatment resistance through network formation. MTs are abundant in chemoresistant gliomas, in particular, glioblastomas (GBMs), while they are uncommon in chemosensitive IDH-mutant and 1p/19q co-deleted oligodendrogliomas. The aim of this study was to identify potential signaling pathways involved in MT formation. Methods Bioinformatics analysis of TCGA was performed to analyze differences between GBM and oligodendroglioma. Patient-derived GBM stem cell lines were used to investigate MT formation under transforming growth factor-beta (TGF-β) stimulation and inhibition in vitro and in vivo in an orthotopic xenograft model. RNA sequencing and proteomics were performed to detect commonalities and differences between GBM cell lines stimulated with TGF-β. Results Analysis of TCGA data showed that the TGF-β pathway is highly activated in GBMs compared to oligodendroglial tumors. We demonstrated that TGF-β1 stimulation of GBM cell lines promotes enhanced MT formation and communication via calcium signaling. Inhibition of the TGF-β pathway significantly reduced MT formation and its associated invasion in vitro and in vivo. Downstream of TGF-β, we identified thrombospondin 1 (TSP1) as a potential mediator of MT formation in GBM through SMAD activation. TSP1 was upregulated upon TGF-β stimulation and enhanced MT formation, which was inhibited by TSP1 shRNAs in vitro and in vivo. Conclusion TGF-β and its downstream mediator TSP1 are important mediators of the MT network in GBM and blocking this pathway could potentially help to break the complex MT-driven invasion/resistance network

Evolution of Occupational Therapy Practice: Life History of Sarah Nielsen, PhD, OTR/L

The purpose of this study was to examine the life of Dr. Sarah Nielsen through the use of a life history approach. The focus of this life history approach was Sarah\u27s involvement in the evolution of OT practice in North Dakota. She is an active and influential individual in the OT profession as she has served various positions in the American Occupational Therapy Association (AOTA) and North Dakota Occupational Therapy Association (NDOTA), as well as a variety of committees at the University of North Dakota (UND). Sarah is currently an associate professor in the Department of OT at the UND. She practiced for ten years at Trinity Child Adolescent Partial Hospitalization at Trinity Health in Minot, North Dakota prior to becoming a professor. The researchers are personally acquainted with Sarah as she is one of their professors in the OT program at UND. This life history is one of 29 life history interviews which are a part of a larger project, Life Histories of Individuals Who Have Been Influential in Developing Occupational Therapy in North Dakota and Wyoming. The purpose of the project is to gather information about the history and evolution of OT practice in North Dakota and Wyoming through life histories of individuals who have been influential in developing OT in these two states. It is anticipated that the life history process will be a powerful way to gather this information. This study is intended to provide current and future generations of occupational therapists a view of the history and how OT practice has evolved from its inception to current practice in North Dakota and Wyoming