Physical Activity Recognition based on Rotated Acceleration Data using Orientation Filter

The purpose of the study was to examine the accuracy of physical activity (PA) classification algorithms using a rotational analysis

Reversible photoluminescence switch: A stair-step Cu4I4 coordination polymer based on a dithioether ligand

AbstractA two-dimensional network stair-step Cu4I4 coordination polymer (1) based on 1,4-bis((methylthio)propanoyl)piperazine was prepared. No emission was observed from 1 (off state), while a heated sample (2) of 1 emitted a strong green light (on state). Conversion between 1 and 2 was reversible upon removal of acetonitrile or exposure of 2 to acetonitrile

Electroacupuncture Attenuates Ovalbumin-Induced Allergic Asthma via Modulating CD4+CD25+ Regulatory T Cells

A mouse pulmonary hypersensitivity experimental model that mimics human asthma was developed, and electroacupuncture (EA) treatment was shown to reduce allergic inflammatory processes. In addition, we also assessed whether the beneficial effects of EA on allergic asthma could be correlated with CD4+CD25+Foxp3+ regulatory T cells (Treg). Cellular profiles and histopathologic analysis demonstrated that peribronchial and perivascular inflammatory cell infiltrates were significantly decreased in the EA-treated groups when compared to the OVA and anti-CD25 Ab-injected (Treg depletion) groups. Furthermore, total BAL cells were reduced in the EA groups when compared to other groups. Interestingly, the population of CD4+CD25+Foxp3+Tregs in pneumonocytes increased in EA-treated group when compared to OVA and Treg depletion groups. These results imply that EA stimulation at ST 36 may affect CD4+CD25+Foxp3+ Treg in an OVA-induced experimental model and may enhance Treg function by suppressing other T cells and limiting the immune response

The Effects of Sentential Context on the Perception of Assimilated Speech

The aims of this study were to examine the effect of sentential context on perceptual compensation for assimilation and to compare compensation patterns between English and Korean listeners with a high proficiency level in English. To these ends, we conducted two experiments involving English coronal place assimilation. In the discrimination experiment, two types of stimuli (i.e., compound words and sentences) were presented. In the identification experiment, a target token including one of the two types of codas (i.e., coronal and non-coronal consonants) was embedded in a semantically neutral sentence. The results showed that in the discrimination experiment both listener groups demonstrated higher detection rates in sentences rather than in words. However, the Korean listeners were not as sensitive as the English listeners to phonetic differences of coda consonants in the unviable change context, and they showed more variations in detection rates than the English listeners. The results of the identification experiment presented a significant effect of coda type of target tokens on both listener groups. In sum, the L2 advanced learners were able to use sentential context to perceive assimilated speech, as were the L1 listeners.This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-2017S1A5A2A01027443)

Clinicopathological characteristics of light chain proximal tubulopathy in Korean patients and the diagnostic usefulness of immunohistochemical staining for immunoglobulin light chain

Light chain proximal tubulopathy (LCPT) is a rare paraproteinemic renal disease that has been mostly reported in Western patients. LCPT is characterized by the accumulation of immunoglobulin (Ig)-light chain (LC) in the proximal tubule. Immunohistochemical staining for Ig-LC has not been investigated in the context of LCPT. We reported the clinicopathological characteristics and Ig-LC immunoexpression of patients with LCPT for the first time in Korea. We reviewed the clinicopathological findings of 5 Korean patients diagnosed with LCPT between 2016 and 2018. In addition, immunohistochemical staining for κ-LC and λ-LC was conducted on paraffin-embedded tissues. The median age was 63 years, and the male-to-female ratio was 3:2. The primary renal manifestations were either azotemia or tubular proteinuria. All patients were diagnosed with multiple myeloma with monoclonal κ-LC (#1–2) or λ-LC (#3–5) in the serum and urine. Kidney biopsies revealed diverse and subtle alterations of the proximal tubule, including crystallization, vacuolization, and/or swelling. Electron microscopy revealed crystals in patients #1–2 and non-crystalline particles within numerous/large/dysmorphic lysosomes in patients #3–5. Ig-LC restriction was demonstrated in the proximal tubule as κ-type in patients #1–2 and as λ-type in patients #3–5 by immunohistochemistry and immunofluorescence. Immunohistochemical staining showed diffuse positivity to κ- and λ-LC, although immunofluorescent staining for κ-LC was focal and weak. LCPT has diverse clinicopathological characteristics and subtle morphological alterations, which necessitate ancillary tests for diagnosis. We introduced immunohistochemical staining for Ig-LC as a useful tool for the diagnosis of LCPT, especially in the case of κ-type crystals