5,779 research outputs found
Dipole-Allowed Direct Band Gap Silicon Superlattices
Silicon is the most popular material used in electronic devices. However, its
poor optical properties owing to its indirect band gap nature limit its usage
in optoelectronic devices. Here we present the discovery of super-stable
pure-silicon superlattice structures that can serve as promising materials for
solar cell applications and can lead to the realization of pure Si-based
optoelectronic devices. The structures are almost identical to that of bulk Si
except that defective layers are intercalated in the diamond lattice. The
superlattices exhibit dipole-allowed direct band gaps as well as indirect band
gaps, providing ideal conditions for the investigation of a direct-to-indirect
band gap transition. The transition can be understood in terms of a novel
conduction band originating from defective layers, an overlap between the
valence- and conduction-band edge states at the interface layers, and zone
folding with quantum confinement effects on the conduction band of
non-defective bulk-like Si. The fact that almost all structural portions of the
superlattices originate from bulk Si warrants their stability and good lattice
matching with bulk Si. Through first-principles molecular dynamics simulations,
we confirmed their thermal stability and propose a possible method to
synthesize the defective layer through wafer bonding
Late-1980s regime shift in the formation of the North Pacific subtropical mode water
Author Posting. © American Geophysical Union, 2020. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research-Oceans 125(2), (2020):
e2019JC015700, doi:10.1029/2019JC015700.The formation mechanism as well as its temporal change of the North Pacific subtropical mode water (NPSTMW) is investigated using a 50âyear (1960â2009) ocean general circulation model hindcast. The volume budget analysis suggests that the formation of the NPSTMW is mainly controlled by the airâsea interaction and ocean dynamics, but there is a regime shift of the relative importance between the two around lateâ1980s. While the local airâsea interaction process is a main driver of the NPSTMW formation prior to lateâ1980s, ocean dynamics including the vertical entrainment become dominant since then. The NPSTMW formation is affected by the North Pacific Oscillation simultaneously in the early period, but with a few years lag in the later period. The interdecadal change of the driving mechanism of the interannual variability of the NPSTMW is probably due to the stronger (weaker) influence of local atmospheric forcing in the western North Pacific and unfavorable (favorable) wind stress curl condition for the remote oceanic forcing from the central North Pacific during the former (later) period. This regime shift may be related to the change of centers of the actions of the wind stress curl since the lateâ1980s.The CORE2 data set was obtained from https://data1.gfdl.noaa.gov/nomads/forms/core/COREv2.html. The World Ocean Atlas 2009 and the Polar Hydrographic Climatology data set were obtained from https://www.nodc.noaa.gov/OC5/WOA09/pr_woa09.html and http://psc.apl.washington.edu/nonwp_projects/PHC/Climatology.html, respectively. The OSCAR data were taken from https://podaac.jpl.nasa.gov/dataset/OSCAR_L4_OC_thirdâdeg. The database of mixed layer depth is downloaded from http://mixedlayer.ucsd.edu. The data set of the Argo floats was taken from http://uskess.whoi.edu/. The sea surface height data observed by the satellite are available from AVISO (http://www.aviso.altimetry.fr/duacs/). The EN4 data set was downloaded from https://www.metoffice.gov.uk/hadobs/en4/. This study was supported by the National Research Foundation of Korea (NRF) Grant NRFâ2009âC1AAA001â0093, funded by the Korea government (MEST). The numerical simulation in this paper was supported by the Supercomputing Center of Korea Institute of Science and Technology Information (KISTI), with its supercomputing resources and technical support (KSCâ2018âCREâ0117). Y.âO. Kwon was funded by National Science Foundation (NSF) EaSM2 OCEâ1242989. Y. H. Kim was partly supported by research projects entitled âInvestigation and prediction system development of marine heatwave around the Korean Peninsula originated from the subarctic and western Pacificâ (20190344) funded by the Ministry of Oceans and Fisheries (MOF). G. Pak was supported by inâhouse projects of the Korea Institute of Ocean Science & Technology (PE99711, PE99811).2020-09-0
The Influence Of Job Insecurity On Career Commitment And Attitude In Multinational Corporations
As the perception of lifelong work shifts into lifelong career in the job insecurity market, the career development of employees through professional and competitive career management has become more important than being loyal to a lifelong work. Furthermore, in the case of multinational corporations, such as differentiation from the head office policy, cultural differences in labor relations, and the liquidity of business withdrawal, such a feature has a higher possibility of job insecurity than general companies. Therefore, the purpose of this study is to verify empirically how job insecurity influences career commitment and career attitude through individual, job and career characteristics as intermediation with the members of multinational corporations as objectives. For this purpose, a total of 366 questionnaire data that targeted 27 multinational corporations were collected and analyzed. The result shows that the job insecurity of multinational corporations affects individual characteristic rather than job or career characteristic, and it is confirmed that individual characteristic has an effect on career commitment and career attitude. In the end, multinational corporations, unlike ordinary domestic companies, need active organizational career development program that corresponds to an open corporate culture as well as innovative and open systems and policies that balance both internal and external networking activities in terms of human resource management of corporations
Antitumor enhancement of celecoxib, a selective Cyclooxygenase-2 inhibitor, in a Lewis lung carcinoma expressing Cyclooxygenase-2
<p>Abstract</p> <p>Background</p> <p>The goal of this study was to determine the effects of a selective Cyclooxygenase (COX)-2 inhibitor on the inhibition of tumor growth and pulmonary metastasis in a Lewis Lung Carcinoma (LLC) animal model.</p> <p>Methods</p> <p>For immunoblot analysis of COX-2 and PGE2, cells were treated with irradiation in the presence or absence of celecoxib. The right thighs of male, 6-week old C57/BL mice were subcutaneously injected with 1 Ă 10<sup>6 </sup>LLC cells. The animals were randomized into one of six groups: (1) no treatment, (2) 25 mg/kg celecoxib daily, (3) 75 mg/kg celecoxib daily, (4) 10 Gy irradiation, (5) 10 Gy irradiation plus 25 mg/kg celecoxib daily, and (6) 10 Gy irradiation plus 75 mg/kg celecoxib daily. Mice were irradiated only once, and celecoxib was administered orally. Mice were irradiated with 4-MV photons once the tumor volume of the control group reached 500 mm<sup>3</sup>. All mice were sacrificed when the mean tumor volume of control animals grew to 4000 mm<sup>3</sup>. The left lobes of the lungs were extracted for the measurement of metastatic nodules.</p> <p>Results</p> <p>Irradiation resulted in a dose-dependent increase in PGE2 production. PGE2 synthesis decreased markedly after treatment with celecoxib alone or in combination with irradiation. Compared to mice treated with low dose celecoxib, mean tumor volume decreased significantly in mice treated with a high dose of celecoxib with or without irradiation. Mice treated with a high dose celecoxib alone, with irradiation alone, or with irradiation plus celecoxib had markedly fewer metastatic lung nodules than controls. The mean metastatic area was the smallest for mice treated with irradiation plus a high dose celecoxib.</p> <p>Conclusion</p> <p>Oral administration of high dose celecoxib significantly inhibited tumor growth, as compared to a low dose treatment. Radiotherapy in combination with high dose celecoxib delayed tumor growth and reduced the number of pulmonary metastases to a greater extent than celecoxib or radiotherapy alone.</p
Identification of protein functions using a machine-learning approach based on sequence-derived properties
<p>Abstract</p> <p>Background</p> <p>Predicting the function of an unknown protein is an essential goal in bioinformatics. Sequence similarity-based approaches are widely used for function prediction; however, they are often inadequate in the absence of similar sequences or when the sequence similarity among known protein sequences is statistically weak. This study aimed to develop an accurate prediction method for identifying protein function, irrespective of sequence and structural similarities.</p> <p>Results</p> <p>A highly accurate prediction method capable of identifying protein function, based solely on protein sequence properties, is described. This method analyses and identifies specific features of the protein sequence that are highly correlated with certain protein functions and determines the combination of protein sequence features that best characterises protein function. Thirty-three features that represent subtle differences in local regions and full regions of the protein sequences were introduced. On the basis of 484 features extracted solely from the protein sequence, models were built to predict the functions of 11 different proteins from a broad range of cellular components, molecular functions, and biological processes. The accuracy of protein function prediction using random forests with feature selection ranged from 94.23% to 100%. The local sequence information was found to have a broad range of applicability in predicting protein function.</p> <p>Conclusion</p> <p>We present an accurate prediction method using a machine-learning approach based solely on protein sequence properties. The primary contribution of this paper is to propose new <it>PNPRD </it>features representing global and/or local differences in sequences, based on positively and/or negatively charged residues, to assist in predicting protein function. In addition, we identified a compact and useful feature subset for predicting the function of various proteins. Our results indicate that sequence-based classifiers can provide good results among a broad range of proteins, that the proposed features are useful in predicting several functions, and that the combination of our and traditional features may support the creation of a discriminative feature set for specific protein functions.</p
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