L'ordre des éléments de la phrase en coréen : esquisse de syntaxe énonciative

The aim of this study is to show how, in deep structure operations, word order in Korean takes on an important metalinguistic dimension, affecting the way the speakers see the world. Guillaume's psycho-mechanical theory, insofar as it does not cut off the speech act from the speaker and the context of communication is particularly well-equipped to examine this question.The study starts with the identification of the immediate constituents of the simple sentence in Korean (semasiological approach). Next, with a view to highlighting the morpho-syntactical and semantic organization of the language, the variations in meaning obtained by the different internal ordering of each functional constituent unit is examined at word level, at phrase level and at sentence level. To what extent is the speaker free to choose the order in which he arranges the elements of the sentence he instantiates in the speech act? These are just some of the questions that this study tries to answer. This study comprises four parts. The first examines the structure of Korean sentence: from the sentence to the phrase. The second focuses on the disposition of sentence constituents. The third part investigates the order of the constituents within the noun phrase, comparing relative positions of the determinant in the phrase. This relates to the rules governing the combination of lexical words and grammatical words; this sheds light on the internal syntax of each functional constituent of the utterance. Finally, the last part is devoted to syntax of the adverb, based on its mobility and the way that position affects adverbial incidence.L’enjeu de la présente étude est de montrer que l'ordre des mots acquiert un rôle métalinguistique important dans le système des opérations internes de la langue : il connote la manière de penser le monde phénoménal. Pour cette étude sur le coréen, la théorie que nous avons choisie est la systématique énonciative. Cette théorie met en œuvre une analyse qui ne sépare pas le Discours des conditions linguistiques de sa production. Dépassant le cadre d’une systématique des langues, elle rappelle qu’un énoncé n'est jamais isolé du contexte linguistique et situationnel où se trouve le sujet parlant. Nous commencerons par l’observation de l'énoncé fondamental, afin de dégager ses unités constitutives fonctionnelles ; en d’autres termes, nous adopterons la démarche sémasiologique, mais à partir des conditions d'énonciation et de la situation de production de l'énoncé. Nous examinerons ensuite l'ordre interne des éléments de l'unité constitutive fonctionnelle, qui relève aussi bien du domaine morpho-syntaxique que sémantique. Nous verrons que l’ordre à l’intérieur du syntagme et le choix du mot formel en coréen constituent un mécanisme majeur de la syntaxe coréenne, mécanisme qui dépend de la visée d’effet du locuteur. Si chaque langue a sa manière d’organiser les éléments au sein d’une unité donnée, c’est que chaque langue analyse à sa façon la perception du monde expérientiel. Quel est alors l’ordre prescrit par le système linguistique du coréen, au niveau du mot, du syntagme et de la phrase ? Quelle est la liberté de manœuvre du locuteur au moment de la construction de la phrase dans l’acte de langage ? C’est à ces deux questions que ce travail a tenté d’apporter une réponse. La présente étude comporte quatre parties. La première partie propose d’examiner la structure de l’énoncé : de l’énoncé au syntagme. La deuxième partie explique la disposition des constituants dans l’énoncé. La troisième partie étudie l’ordre des éléments au sein du syntagme nominal, en fonction de la place du déterminant. Cela concerne la logique combinatoire du mot matériel et du mot formel qui relève essentiellement de la syntaxe interne d’une unité constitutive fonctionnelle de l'énoncé. Enfin, la quatrième partie se consacre à une syntaxe de l’adverbe, basée sur sa mobilité au sein de l’énoncé, mobilité qui affecte l’incidence adverbiale

Synergistic multi-doping effects on the Li7La3Zr2O12 solid electrolyte for fast lithium ion conduction.

Here, we investigate the doping effects on the lithium ion transport behavior in garnet Li7La3Zr2O12 (LLZO) from the combined experimental and theoretical approach. The concentration of Li ion vacancy generated by the inclusion of aliovalent dopants such as Al(3+) plays a key role in stabilizing the cubic LLZO. However, it is found that the site preference of Al in 24d position hinders the three dimensionally connected Li ion movement when heavily doped according to the structural refinement and the DFT calculations. In this report, we demonstrate that the multi-doping using additional Ta dopants into the Al-doped LLZO shifts the most energetically favorable sites of Al in the crystal structure from 24d to 96 h Li site, thereby providing more open space for Li ion transport. As a result of these synergistic effects, the multi-doped LLZO shows about three times higher ionic conductivity of 6.14 × 10(-4) S cm(-1) than that of the singly-doped LLZO with a much less efforts in stabilizing cubic phases in the synthetic condition

Biアンチドット薄膜における低次元電子状態に関する研究

学位の種別:課程博士University of Tokyo(東京大学

Characterization of Fabry mice treated with recombinant adeno-associated virus 2/8-mediated gene transfer

<p>Abstract</p> <p>Background</p> <p>Enzyme replacement therapy (ERT) with α-galactosidase A (α-Gal A) is currently the most effective therapeutic strategy for patients with Fabry disease, a lysosomal storage disease. However, ERT has limitations of a short half-life, requirement for frequent administration, and limited efficacy for patients with renal failure. Therefore, we investigated the efficacy of recombinant adeno-associated virus (rAAV) vector-mediated gene therapy for a Fabry disease mouse model and compared it with that of ERT.</p> <p>Methods</p> <p>A pseudotyped rAAV2/8 vector encoding α-Gal A cDNA (rAAV2/8-hAGA) was prepared and injected into 18-week-old male Fabry mice through the tail vein. The α-Gal A expression level and globotriaosylceramide (Gb3) levels in the Fabry mice were examined and compared with Fabry mice with ERT. Immunohistochemical and ultrastructural studies were conducted.</p> <p>Results</p> <p>Treatment of Fabry mice with rAAV2/8-hAGA resulted in the clearance of accumulated Gb3 in tissues such as liver, spleen, kidney, heart, and brain with concomitant elevation of α-Gal A enzyme activity. Enzyme activity was elevated for up to 60 weeks. In addition, expression of the α-Gal A protein was identified in the presence of rAAV2/8-hAGA at 6, 12, and 24 weeks after treatment. α-Gal A activity was significantly higher in the mice treated with rAAV2/8-hAGA than in Fabry mice that received ERT. Along with higher α-Gal A activity in the kidney of the Fabry mice treated with gene therapy, immunohistochemical studies showed more α-Gal A expression in the proximal tubules and glomerulus, and less Gb3 deposition in Fabry mice treated with this gene therapy than in mice given ERT. The α-gal A gene transfer significantly reduced the accumulation of Gb3 in the tubules and podocytes of the kidney. Electron microscopic analysis of the kidneys of Fabry mice also showed that gene therapy was more effective than ERT.</p> <p>Conclusions</p> <p>The rAAV2/8-hAGA mediated α-Gal A gene therapy provided improved efficiency over ERT in the Fabry disease mouse model. Furthermore, rAAV2/8-hAGA-mediated expression showed a greater effect in the kidney than ERT.</p

Urinary bladder rupture during voiding cystourethrography

Voiding cystourethrography (VCUG) is a commonly performed diagnostic procedure for the evaluation of vesicoureteral reflux with urinary tract infection or congenital renal diseases in children. The procedure is relatively simple and cost-effective, and complications are very rare. The iatrogenic complication of VCUG range from discomfort, urinary tract infection to bacteremia, as well as bladder rupture. Bladder rupture is a rare complication of VCUG, and only a few cases were reported. Bladder rupture among healthy children during VCUG is an especially uncommon event. Bladder rupture associated with VCUG is usually more common in chronically unused bladders like chronic renal failure. Presented is a case of bladder rupture that occurred during a VCUG in a healthy 9-month-old infant, due to instilled action of dye by high pressure. This injury completely healed after 7 days of operation, and it was confirmed with a postoperative cystography. The patient's bladder volume, underlying disease, velocity of the contrast media instilled, catheter size, and styles of instillation are important factors to prevent bladder rupture during VCUG. Management of bladder rupture should be individualized, but the majority of infants are treated with the operation. In conclusion, bladder rupture is a rare complication, however, delicate attention is needed in order to prevent more dire situations

Fixed Drug Eruption Due to Allopurinol: Positive Oral Provocation

A fixed drug eruption (FDE) is characterized by the presence of a solitary or multiple, pruritic, well-circumscribed, erythematous plaques. These lesions have tendency to recur at same sites and heal with residual hyperpigmenation. With repeated attacks, the size and/or number of the lesions may increase. So far, more than 100 drugs have been implicated in causing FDEs, including ibuprofen, sulfonamide, naproxen, and tetracylines. FDE caused by allopurinol has been rarely reported in the literature, but there has been no confirmed case based on oral provocation test. Herein, we report a case of FDE in which the lesions recurred whenever allopurinol was administered for the treatment of gout. A 64-year-old male experienced repeated episodes of well-demarcated dusky erythematous patches on the whole body for 2 months. He took allopurinol intermittently for amelioration of his gout symptom, but denied other medication history. Pruritic erythematous edema developed on the previous lesions 12 hours after oral provocation of 200 mg of allopurinol

Effect of alcohol use on emergency department length of stay among minimally injured patients based on mechanism of injury: multicenter observational study

Objective This study aimed to evaluate the effect of alcohol use on emergency department (ED) length of stay (LOS) among minimally injured patients by mechanism of injury. Methods This was a retrospective study of injury surveillance data for injured patients (except poisoning), aged over 18 years, discharged home from the ED, and treated at seven academic EDs in Korea during 2008 to 2012. Patients were divided into alcohol-related and alcohol-unrelated groups based on self-report. We used multivariable quantile regression models for the analysis and adjusted covariates including age, sex, consciousness status, severity of injury, emergency medical service use, the season, day and time of visit, and hospital. To determine if there were different effects of alcohol use across mechanism of injury, all analyses were stratified by each mechanism. Results Among 192,200 patients, 95,807 patients were analyzed. The number of participants in the alcohol-related group was 16,249 (17.0%). In the multivariable quantile regression model, the alcohol-related group had significantly longer ED LOS at the 10th (7 minutes; 95% confidence interval [CI], 6 to 8), 50th (21 minutes; 95% CI, 19 to 23), and 90th (81 minutes; 95% CI, 74 to 87) percentiles when compared to the alcohol-unrelated group. The effect of alcohol use on increased ED LOS was most prominent in motor vehicle injuries. Conclusion We found that alcohol use was associated with increased emergency ED LOS. Furthermore, if we limited our attention to the effect of alcohol use on the number of patients, the burden of alcohol use on the ED would have been underestimated